Breast Cancer Resistance Protein (BCRP) in Acute Leukaemia

REFERENCES

• Gottesman, M.M., Fojo, T. and Bates, S.E. (2002) "Multidrug resistance in cancer: role of ATP-dependent transporters", Nature Reviews Cancer, 2, 48— 58.
   PubMed Web of Science ®Google Scholar
• Chauncey, T.R. (2001) "Drug resistance mechanisms in acute leukemia", Current Opinions in Oncology, 13, 21–26.
   PubMed Web of Science ®Google Scholar
• Marie, J.P. and Legrand, O. (1999) "MDR1/P-GP expression as a prognostic factor in acute leukemias", Advances in Experimental Medicine and Biology, 457, 1 — 9.
   Google Scholar
• Chen, Y.N., Mickley, L.A., Schwartz, A.M., Acton, E.M., Hwang, J.L. and Fojo, A.T. (1990) "Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein", Journal of Biological Chemistry, 265, 10073–10080.
   Google Scholar
• Doyle, L.A., Yang, W., Abruzzo, L.V., Krogmann, T., Gao, Y., Rishi, A.K., et al. (1998) "A multidrug resistance transporter from human MCF-7 breast cancer cells", Proceedings of the National Academy of Sciences of the United States of America, 95, 15665 — 15670.
   Google Scholar
• Lee, JS., Scala, S., Matsumoto, Y., Dickstein, B., Robey, R., Zhan, Z., et al. (1997) "Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression", Journal of Cellular Biochem-istry, 65, 513–526.
   Google Scholar
• Allikmets, R., Schriml, L.M., Hutchinson, A., Romano-Spica, V. and Dean, M. (1998) "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance", Cancer Research, 58, 5337 — 5339.
   Google Scholar
• Miyake, K., Mickley, L., Litman, T., Zhan, Z., Robey, R., Cristensen, B., et al. (1999) "Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstra-tion of homology to ABC transport genes", Cancer Research, 59, 8 — 13.
   Google Scholar
• Bailey-Dell, K.J., Hassel, B., Doyle, L.A. and Ross, D.D. (2001) "Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene", Biochimica et Biophysica Acta, 1520, 234 — 241.
   Google Scholar
• Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T., et al. (2002) "Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization", International Journal of Cancer, 97, 626–630.
   Google Scholar
• Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D.D., et al. (2000) "The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)", Journal of Cell Science, 113, 2011— 2021.
   PubMed Web of Science ®Google Scholar
• Rabindran, S.K., He, H., Singh, M., Brown, E., Collins, K.I., Annable, T., et al. (1998) "Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C", Cancer Research, 58, 5850–5858.
   Google Scholar
• Maliepaard, M., Scheffer, G.L., Faneyte, IF., van Gastelen, M.A., Pijnenborg, AC., Schinkel, A.H., et al. (2001) "Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues", Cancer Research, 61, 3458 — 3464.
   Google Scholar
• Rocchi, E., Khodjakov, A., Volk, EL., Yang, C.H., Litman, T., Bates, SE., et al. (2000) "The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane", Biochemical and Biophysical Research Communications, 271, 42–46.
   PubMed Web of Science ®Google Scholar
• Scheffer, G.L., Maliepaard, M., Pijnenborg, A.C., van Gastelen, M.A., de Jong, M.C., Schroeijers, A.B., et al. (2000) "Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines", Cancer Research, 60, 2589 — 2593.
   Google Scholar
• Cooray, H.C., Blackmore, C.G., Maskell, L. and Barrand, M.A. (2002) "Localisation of breast cancer resistance protein in micro-vessel endothelium of human brain", Neuroreport, 13, 2059–2063.
   Google Scholar
• Bart, J., Groen, H.J., van der Graaf, W.T., Hollema, H., Hendrikse, N.H., Vaalburg, W., et al. (2002) "An oncological view on the blood-testis barrier", Lancet Oncology, 3, 357–363.
   PubMed Web of Science ®Google Scholar
• Goodell, M.A., Brose, K., Paradis, G., Conner, A.S. and Mulligan, R.C. (1996) "Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo", Journal of Experimental Medicine, 183, 1797 — 1806.
   Web of Science ®Google Scholar
• Spangrude, G.J. and Johnson, G.R. (1990) "Resting and activated subsets of mouse multipotent hematopoietic stem cells", Proceed-ings of the National Academy of Sciences of the United States of America, 87, 7433–7437.
   Google Scholar
• Zhou, S., Morris, Li., Barnes, Y., Lan, L., Schuetz, J.D. and Sorrentino, B.P. (2002) "Bcrp 1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo", Proceedings of the National Academy of Sciences of the United States of America, 99, 12339 — 12344.
   Google Scholar
• Scharenberg, C.W., Harkey, M.A. and Torok-Storb, B. (2002) "The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic pro-genitors", Blood, 99, 507 — 512.
   Google Scholar
• Zhou, S., Schuetz, JD., Bunting, K.D., Colapietro, AM., Sampath, J., Morris, J.J., et al. (2001) "The ABC transporter Bcrpl/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype", Nature Medicine, 7, 1028 — 1034.
   Google Scholar
• Good, J.R. and Kuspa, A. (2000) "Evidence that a cell-type-specific efflux pump regulates cell differentiation in Dictyostelium", Devel-opmental Biology, 220, 53–61.
   Google Scholar
• Jonker, J.W., Buitelaar, M., Wagenaar, E., van der Valk, MA., Scheffer, G.L., Scheper, R.J., et al. (2002) "The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria", Proceedings of the National Academy of Sciences of the United States of America, 99, 15649 — 15654.
   Google Scholar
• Diestra, J.E., Scheffer, G.L., Catala, I., Maliepaard, M., Schellens, J.H., Scheper, R.J., et al. (2002) "Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material", Journal of Pathology, 198, 213–219.
   PubMed Web of Science ®Google Scholar
• Minderman, H., Suvannasankha, A., O'Loughlin, K.L., Scheffer, G.L., Scheper, R.J., Robey, R.W., et al. (2002) "Flow cytometric analysis of breast cancer resistance protein expression and function", Cytometry, 48, 59 — 65.
   Google Scholar
• van der Kolk, D.M., Vellenga, E., Scheffer, G.L., Willer, M., Bates, SE., Scheper, R.J. et al. (2002) "Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia", Blood, 99, 3763–3770.
   Google Scholar
• Litman, T., Jensen, U., Hansen, A., Covitz, KM., Zhan, Z., Fetsch, P., et al. (2002) "Use of peptide antibodies to probe for the mitoxantrone resistance- associated protein MXR/BCRP/ABCP/ ABCG2", Biochimica et Biophysica Acta, 1565, 6–16.
   PubMed Web of Science ®Google Scholar
• Honjo, Y., Hrycyna, CA., Yan, Q.W., Medina-Perez, WY., Robey, R.W., van de Laar, A., et al. (2001) "Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/ BCRP/ABCP-overexpressing cells", Cancer Research, 61, 6635 — 6639.
   Google Scholar
• Robey, R.W., Honjo, Y., van de Laar, A., Miyake, K., Regis, J.T., Litman, T., et al. (2001) "A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2)", Biochimica et Biophysica Acta, 1512, 171–182.
   PubMed Web of Science ®Google Scholar
• de Bruin, M., Miyake, K., Litman, T., Robey, R. and Bates, S.E. (1999) "Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR", Cancer Letters, 146, 117–126.
   PubMed Web of Science ®Google Scholar
• Maliepaard, M., van Gastelen, M.A., Tohgo, A., Hausheer, F.H., van Waardenburg, R.C., de Jong, L.A., et al. (2001) "Circumven-tion of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918", Clinical Cancer Research, 7, 935 —941.
   Google Scholar
• Rabindran, S.K., Ross, D.D., Doyle, L.A., Yang, W. and Green-berger, L.M. (2000) "Fumitremorgin C reverses multidrug resis-tance in cells transfected with the breast cancer resistance protein", Cancer Research, 60, 47–50.
   PubMed Web of Science ®Google Scholar
• Hyafil, F., Vergely, C., Du, V.P. and Grand-Perret, T. (1993) "In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative", Cancer Research, 53,4595–4602.
   Google Scholar
• van Loevezijn, A., Allen, J.D., Schinkel, A.H. and Koomen, G.J. (2001) "Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines", Bioorganic & Medicinal Chemistry Letters, 11, 29 — 32.
   PubMed Web of Science ®Google Scholar
• Allen, J.D., van Loevezijn, A., Lakhai, J.M., van der Valk, M., van Tellingen, O., Reid, G., et al. (2002) "Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C", Molecular Cancer Therapeutics, 1, 417–425.
   Google Scholar
• Allen, J.D., Jackson, S.C. and Schinkel, A.H. (2002) "A mutation hot spot in the Bcrp 1 (Abcg2) multidrug transporter in mouse cell lines selected for doxorubicin resistance", Cancer Research, 62, 2294–2299.
   PubMed Web of Science ®Google Scholar
• Volk, E.L., Farley, K.M., Wu, Y., Li, F., Robey, R.W. and Schneider, E. (2002) "Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance", Cancer Research, 62, 5035 — 5040.
   Google Scholar
• Imai, Y., Nakane, M., Kage, K., Tsukahara, S., Ishikawa, E., Tsuruo, T., et al. (2002) "C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance", Molecular Cancer Therapeutics, 1, 611 — 616.
   Google Scholar
• Ross, D.D., Karp, J.E., Chen, T.T. and Doyle, L.A. (2000) "Expression of breast cancer resistance protein in blast cells from patients with acute leukemia", Blood, 96, 365–368.
   Google Scholar
• Heuvel-Eibrink, M.M., Wiemer, E.A., Prins, A., Meijerink, J.P., Vossebeld, P.J., van der Holt, B., et al. (2002) "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)", Leukemia, 16, 833 — 839.
   Google Scholar
• Steinbach, D., Sell, W., Voigt, A., Hermann, J., Zintl, F. and Sauerbrey, A. (2002) "BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia", Leukemia, 16, 1443–1447.
   Google Scholar
• Abbott, B.L., Colapietro, A.M., Barnes, Y., Marini, F., Andreeff, M. and Sorrentino, B.P. (2002) "Low levels of ABCG2 expression in adult AML blast samples", Blood, 100, 4594 — 4601.
   Google Scholar
• Sargent, J.M., Williamson, C.J., Maliepaard, M., Elgie, A.W., Scheper, R.J. and Taylor, C.G. (2001) "Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia", British Journal of Haematology, 115, 257 — 262.
   Google Scholar
• van der Pol, M.A., Broxterman, H.J., Pater, J.M., Feller, N., van der Maas M., Weijers, G.W., et al. (2003) "Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia", Haematologica, 88, 134 — 147.
   Google Scholar
• Sauerbrey, A., Sell, W., Steinbach, D., Voigt, A. and Zintl, F. (2002) "Expression of the BCRP gene (ABCG2/MXR/ABCP) in child-hood acute lymphoblastic leukaemia", British Journal of Haematol-ogy, 118, 147 — 150.
   Google Scholar
• Stam, R.W., van den Heuvel-Eibrink, M.M., den Boer, M.L., Ebus, M.E.G., Janka-Schaub, G.E., Allen, J.D., et al. (2003) "Multidrug resistance genes in infant acute lymphoblstic leukemia; Ara-C is not a substrate for BCRP", Leukemia, 17, 678 Abstract P33.
   Google Scholar
• Plasschaert, S.L.A., de Bont, E.S.J.M., Kamps, W.A., van der Kolk, D.M., Morisaki, K., Bates, SE., et al. (2003) "Functional activity of breast cancer resistance protein (BCRP) in acute lymphoblastic leukemia", Leukemia, 17, 662 Abstract O16.
   Google Scholar
• Baer, M.R., George, S.L., Dodge, R.K., O'Loughlin, K.L., Mind-erman, H., Caligiuri, M.A., et al. (2002) "Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720", Blood, 100, 1224 — 1232.
   Google Scholar
• Goldman, B. (2003) "Multidrug resistance: can new drugs help chemotherapy score against cancer?", Journal of the National Cancer Institute, 95, 255–257.
   PubMed Web of Science ®Google Scholar
• Allen, J.D., Brinkhuis, R.F., Wijnholds, J. and Schinkel, A.H. (1999) "The mouse Bcrpl/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin", Cancer Research, 59, 4237— 4241.
   Google Scholar
• Brangi, M., Litman, T., Ciotti, M., Nishiyama, K., Kohlhagen, G., Takimoto, C., et al. (1999) "Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-trans-porter (MXR), and potential for glucuronidation in MXR-expres-sing cells", Cancer Research, 59, 5938 — 5946.
   Google Scholar
• Robey, R.W., Medina-Perez, W.V., Nishiyama, K., Lahusen, T., Miyake, K., Litman, T., et al. (2001) "Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells", Clinical Cancer Research, 7, 145 — 152.
   Google Scholar
• Komatani, H., Kotani, H., Hara, Y., Nakagawa, R., Matsumoto, M., Arakawa, H., et al. (2001) "Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure", Cancer Research, 61, 2827–2832.
   PubMed Web of Science ®Google Scholar