Advanced search
Publication Cover
Leukemia & Lymphoma Volume 45, 2004 - Issue 4
Submit an article Journal homepage
205
Views
94
CrossRef citations to date
0
Altmetric
Original Article

Central Nervous System Failure in Patients with Chronic Myelogenous Leukemia Lymphoid Blast Crisis and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Treated with Imatinib (STI-571)

Jose F Leis Adult Bone Marrow Transplant Program, Oregon Health and Sciences University, Portland, OR, 97201, USACorrespondence[email protected]
,
Daniel E Stepan Leukemia Center, Oregon Health and Sciences University, Portland, OR, 97201, USA
,
Peter T Curtin Novartis Pharmaceuticals, Basel, Switzerland
,
John M Ford Adult Bone Marrow Transplant Program, Oregon Health and Sciences University, Portland, OR, 97201, USA
,
Bin Peng Leukemia Center, Oregon Health and Sciences University, Portland, OR, 97201, USA
,
Susan Schubach Novartis Pharmaceuticals, Basel, Switzerland
,
Brian J Druker Adult Bone Marrow Transplant Program, Oregon Health and Sciences University, Portland, OR, 97201, USA
&
Richard T Maziarz Leukemia Center, Oregon Health and Sciences University, Portland, OR, 97201, USA
 show all
Pages 695-698 | Received 17 Jul 2003, Published online: 03 Aug 2009

References

  • Faderl, S., Talpaz, M., Estrov, Z., O'Brien, S.P., Kurzrock, R. and Kantarjian, H.M. (1999) "The biology of chronic myeloid leukemia", N. Engl. J. Med., 341, 164 — 172.
  • Sawyers, C.L. (1999) "Chronic myeloid leukemia", N. Engl. J. Med., 340, 1330–1340.
  • Copelan, E.A. and McGuire, E.A. (1995) "The biology and treatment of acute lymphoblastic leukemia in adults", Blood, 85, 1151–1168.
  • Berg, S.L., Steuber, P. and Poplack, D.G. (2000) Clinical manifesta-tions of acute lymphoblastic leukemia. In Hematology: basic principles and practice (3rd edn). edited by R. Hoffman, E.J. Benz, S.J. Shattil, B. Furie, H.J. Cohen, L.E. Silberstein and P.B. McGlave. Pp. 1070–1078. Philadelphia, PA: Churchill Livingstone.
  • Abbot, N.J. and Romero, I.A. (1996) "Transporting therapeutics across the blood-brain barrier", MoL Med. Today, 2, 106–113.
  • Kroll, R.A. and Neuwelt, E.A. (1998) "Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means", Neurosurgery, 42, 1083 — 1100.
  • Cornford, E.M. and Hyman, S. (1999) "Blood-brain barrier permeability to small and large molecules", Adv. Drug Del. Rev., 36, 145 — 163.
  • Druker, B.J., Tamura, S., Buchdunger, E., et al. (1996) "Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells", Nat. Med., 2, 561–566.
  • Deininger, M.W., Goldman, J.M., Lydon, N. and Melo, J.V. (1997) "The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells", Blood, 90, 3691–3698.
  • Druker, B.J., Sawyers, C.L., Kantarjian, H., et al. (2001) "Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome", N. Engl. J. Med., 344, 1038 — 1042.
  • Sawyers, C.L., Hochhaus, A., Feldman, E., Goldman, J., Miller, C., Ottmann, O., et al. (2002) "Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study", Blood, 99, 3530–3539.
  • Ottmann, O.G., Druker, B.J., Sawyers, C.L., Goldman, J.M., Reiffers, J., Silver, R.T., et al. (2002) "A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias", Blood, 100, 1965–1971.
  • Druker, B.J., Talpaz, M., Resta, D.J., et al. (2001) "Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia" N. Engl. J. Med., 344, 1031–1037.
  • Petzer, A.L., Gunsilius, E., Hayes, M., Stockhammer, G., Duba, H.C., Schneller, F., et al. (2002) "Low concentrations of STI571 in the cerebrospinal fluid: a case report", Br. J. Haematot, 117, 623 — 625.
  • Takayama, N., Sato, N., O'Brien, S.G., Ikeda, Y. and Okamoto, S. (2002) "Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid", Br. J. Haematol., 119, 106–108.
  • Mahon, F.X., Deininger, M.W., Schultheis, B., et al. (2000) "Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor 5TI571: diverse mechanisms of resistance", Blood, 96, 1070–1079.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.