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Leukemia & Lymphoma Volume 45, 2004 - Issue 6
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Original Article

Heterogeneity of Response to Imatinib-Mesylate (Glivec) in Patients with Hypereosinophilic Syndrome: Implications for Dosing and Pathogenesis

Pellegrino Musto Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, ItalyCorrespondence[email protected]
,
Antonietta Falcone Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Grazia Sanpaolo Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Carlo Bodenizza Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Gianni Perla Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Maria Marta Minervini Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Nicola Cascavilla Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Matteo Dell'olio Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Antonio La Sala Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Saverio Mantuano Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Lorella Melillo Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Michele Nobile Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Potito Rosario Scalzulli Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
,
Michele Bisceglia Service of Pathologic Anatomy, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
&
Angelo Michele Carella Unit of Hematology and Stem Cell Transplantation, IRCCS “Casa Sollievo della Sofferenza”, 71013, S. Giovanni Rotondo, Italy
 show all
Pages 1219-1222 | Received 25 Oct 2003, Published online: 03 Aug 2009

Reference

  • Gleich, G.J., Leiferman, KM., Pardanani, P., Tefferi, A. and Butterfield, J.H. (2002) "Treatment of hypereosinophilic syndrome with imatinib mesylate", Lancet, 359, 1577— 1578.
  • Cools, J., De Angelo, D., Gotlib, J., Stover, E.H., Legare, R.D., Cortes, J., et al. (2003) "A tyrosine-kinase created by fusion of the PDGFRA and FIP ILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome", New England Journal of Medicine, 348, 1201–1214.
  • Pardanani, A., Reeder, T., Porrata, L.F., Li, C.V., Tazelaar, H.D., Baxter, E.J., et al. (2003) "Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders", Blood, 101, 3391 — 3397.
  • Cortes, J.E., Ault, P., Koller, C., Thomas, D., Ferrajoli, A., Wierda, W., et al. (2003) "Efficacy of imatinib mesylate in the treatment of hypereosinophilic syndrome", Blood, 101, 4714–4716.
  • Kantarjian, H., Sawyers, C., Hochhaus, A., Guilhot, F., Schiffer, C., Gambacorti-Passerini, C., et al. (2002) "Hematologic and cytoge-netic responses to imatinib mesylate in chronic myelogenous leukemia", New England Journal of Medicine, 346, 645–642.
  • Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., et al. (2001) "Activity of the specific inhibitor of BCR/ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome", New England Journal of Medicine, 344, 1038 — 1042.
  • Demetri, G.D., von Mehren, M., Blanke, C.D., Van den Abbeele, AD., Eisenberg, B., Roberts, P.J., et al. (2002) "Efficacy and safety of imatinib mesylate in advanced, gastrointestinal stromal tumors", New England Journal of Medicine, 347, 472–480.
  • Apperley, J.F., Gardembas, M., Melo, J.V., Russelll-Jones, R., Bain, B.J., Baxter, E.J., et al. (2002) "Response to imatinib in patients with chronic myeloproliferative diseases with rearrange-ments of the platelet-derived growth factor receptor beta", New England Journal of Medicine, 347, 481 —487.
  • Schwartz, R.S. (2003) "The hypereosinophilic syndrome and the biology of cancer", New England Journal of Medicine, 348, 1199 — 1200.
  • Weller, P.F. and Bubley, G.J. (1994) "The idiopathic hypereosino-philic syndrome", Blood, 83, 2759–2779.
  • Roufosse, F., Schandene, L., Sibille, C., Willard-Gallo, K., Kennes, B., Efira, A., et al. (2000) "Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome", British Journal of Haematology, 109, 540–548.
  • Bain, B.J. (2002) "Hypereosinophilia", Current Opinion in Hema-tology, 7, 21 — 25.

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