82
Views
22
CrossRef citations to date
0
Altmetric
Original Article

PI3-Kinase Regulates Survival of Chronic Lymphocytic Leukemia B-Cells by Preventing Caspase 8 Activation

Pages 1519-1529 | Received 26 Jan 2004, Published online: 26 Aug 2009

References

  • Plate, J.M., Petersen, K.S., Buckingham, L., Shahidi, H. and Schofield, C.M. (2000) "Gene expression in chronic lymphocytic leukemia B cells and changes during induction of apoptosis", Exp. HematoL, 28, 1214 — 1224.
  • Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., et al. (2001) "Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells", J. Exp. Med., 194, 1625–1638.
  • Rosenwald, A., Alizadeh, A.A., Widhopf, G., Simon, R., Davis, R.E., Yu, X., et al. (2001) "Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia", J. Exp. Med., 194, 1639 — 1647.
  • Datta, S.R., Brunet, A. and Greenberg, M.E. (1999) "Cellular survival: a play in three Akts", Genes Dev., 13, 2905–2927.
  • Plate, J.M. and Schofield, C.M. (2000) "Cell cycle status and signaling pathways in chronic lymphocytic leukemia cells", Blood, 96, 166b.
  • Plate, J.M.D., Naeem, V.S., Gregory, S.A. and Schofield, C.M. (2001) "Survival signals in chronic lymphocytic leukemia cells that are P13-kinase dependent", Leukemia and Lymphoma, 42S1, 31.
  • Barragan, M., Bellosillo, B., Campas, C., Colomer, D., Pons, G. and Gil, J. (2002) "Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells", Blood, 99, 2969 — 2976.
  • Ringshausen, I., Schneller, F., Bogner, C., Hipp, S., Duyster, J., Peschel, C., et al. (2002) "Constitutively activated phosphatidyli-nositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta", Blood, 100, 3741 — 3748.
  • Newton, K. and Strasser, A. (2003) "Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system", Genes Dev., 17, 819–825.
  • Muzio, M., Stockwell, B.R., Stennicke, H.R., Salvesen, G.S. and Dixit, V.M. (1998) "An induced proximity model for caspase-8 activation", J. Biol. Chem., 273, 2926–2930.
  • Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. and Wallach, D. (1996) "Involvement of MACH, a novel MORT1/FADD-interact-ing protease, in Fas/APO-1- and TNF receptor-induced cell death", Cell, 85, 803–815.
  • Jones, D.T., Ganeshaguru, K., Virchis, A.E., Folarin, NI., Lowdell, M.W., Mehta, A.B., et al. (2001) "Caspase 8 activation independent of Fas (CD95/AP0-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation", Blood, 98, 2800–2807.
  • King, D., Pringle, J.H., Hutchinson, M. and Cohen, G.M. (1998) "Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.", Leukemia, 12, 1553— 1560.
  • Pedersen, I.M., Kitada, S., Schimmer, A., Kim, Y., Zapata, J.M., Charboneau, L., et al. (2002) "The triterpenoid CDDO induces apoptosis in refractory CLL B cells", Blood, 100, 2965–2972.
  • Long, B.W., Witte, P.L., Abraham, G.N., Gregory, S.A. and Plate, J.M. (1995) "Apoptosis and interleulcin 7 gene expression in chronic B-lymphocytic leukemia cells", Proc. Natl. Acad. Sci. USA, 92, 1416–1420.
  • Chen, R., Kim, 0., Yang, J., Sato, K., Eisenmann, K.M., McCarthy, J., Chen, H. and Qiu, Y. (2001) "Regulation of Akt/ PKB activation by tyrosine phosphorylation", J. Biol. Chem., 276, 31858–31862.
  • Gold, M.R., Scheid, M.P., Santos, L., Dang-Lawson, M., Roth, R.A., Matsuuchi, L., et al. (1999) "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase", J. ImmunoL, 163, 1894— 1905.
  • Craxton, A., Jiang, A., Kurosaki, T. and Clark, E.A. (1999) "Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt", J. Biol. Chem., 274, 30644–30650.
  • Pogue, S.L., Kurosalci, T., Bolen, J. and Herbst, R. (2000) "B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase", J. ImmunoL, 165, 1300— 1306.
  • Li, H.L., Davis, W.W., Whiteman, E.L., Birnbaum, M.J. and Pure, E. (1999) "The tyrosine lcinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes", Proc. Natl. Acad. Sci. USA, 96, 6890–6895.
  • Inabe, K. and Kurosalci, T. (2002) "Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement", Blood, 99, 584— 589.
  • Edinger, A.L., Linardic, C.M., Chiang, G.G., Thompson, C.B. and Abraham, R.T. (2003) "Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells", Cancer Res., 63, 8451— 8460.
  • Kops, G.J. and Burgering, B.M. (1999) "Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling", J. MoL Med., 77, 656 — 665.
  • Crowder, R.J. and Freeman, R.S. (2000) "Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal", J. Biol. Chem., 275, 34266— 34271.
  • Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M. and Hemmings, B.A. (1995) "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B", Nature, 378, 785–789.
  • Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., et al. (1999) "PDK 1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2", Curr. Biol., 9, 393–404.
  • Diehl, J.A., Cheng, M., Roussel, M.F. and Sherr, C.J. (1998) "Glycogen synthase kinase-3beta regulates cyclin DI proteolysis and subcellular localization", Genes Dev., 12, 3499— 3511.
  • Sherr, C.J. (1995) "D-type cyclins", Trends Biochem. Sci., 20, 187–190.
  • Pap, M. and Cooper, G.M. (1998) "Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway", J. Biol. Chem., 273, 19929— 19932.
  • Mora, A., Sabio, G., Gonzalez-Polo, R.A., Cuenda, A., Alessi, DR., Alonso, J.C., et al. (2001) "Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K + deprivation in cerebellar granule cells", J. Neurochem., 78, 199 — 206.
  • Zhu, Y., Loukola, A., Month, 0., Kuokkanen, K., Franssila, K., Elonen, E., et al. (2001) "PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas", Leuk. Lymphoma, 41, 177 — 183.
  • Ryves, W.J. and Harwood, A.J. (2001) "Lithium inhibits glycogen synthase kinase-3 by competition for magnesium", Biochem. Biophys. Res. Commun., 280, 720–725.
  • Klein, P.S. and Melton, D.A. (1996) "A molecular mechanism for the effect of lithium on development", Proc. Natl. Acad. Sci. USA, 93, 8455–8459.
  • Grimes, CA. and Jope, R.S. (2001) "CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium". J. Neurochem., 78, 1219 — 1232.
  • Mora, A., Sabio, G., Risco, A.M., Cuenda, A., Alonso, J.C., Soler, G. et al. (2002) "Lithium blocks the PKB and GSK3 depho-sphorylation induced by ceramide through protein phosphatase-2A", Cell Signal, 14, 557 — 562.
  • Khwaja, A. (1999) "Akt is more than just a Bad kinase", Nature, 401, 33–34.
  • Romashkova, J.A. and Makarov, S.S. (1999) "NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling", Nature, 401, 86–90.
  • Ozes, ON., Mayo, L.D., Gustin, JA., Pfeffer, SR., Pfeffer, L.M. and Donner, D.B. (1999) "NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase", Nature, 401, 82–85.
  • Chang, D.W., Xing, Z., Pan, Y., Algeciras-Schimnich, A., Barnhart, B.C., Yaish-Ohad, S., et al. (2002) "c-FLIP(L) is a dual function regulator for caspase —8 activation and CD95-mediated apoptosis", EMBO J., 21, 3704–3714.
  • Dijkers, P.F., Medemadagger, R.H., Lammers, ii., Koenderman, L. and Coffer, P.J. (2000) "Expression of the pro-apoptotic bc1-2 family member bim is regulated by the forkhead transcription factor FKHR-L1", Curr. Biol., 10, 1201–1204.
  • Cardone, M.H., Roy, N., Stennicke, H.R., Salvesen, G.S., Franke, T.F., Stanbridge, E., etal. (1998) "Regulation of cell death protease caspase-9 by phosphorylation", Science, 282, 1318— 1321.
  • Datta, SR., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., et al. (1997) "Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery", Cell, 91, 231–241.
  • Kitada, S., Andersen, J., Akar, S., Zapata, J.M., Takayama, S., Krajewslci, S., et al. (1998) "Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses", Blood, 91, 3379–3389.
  • Panka, D.J., Mano, T., Suhara, T., Walsh, K. and Mier, J.W. (2001) "Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP ex-pression in tumor cells", J. Biol. Chem., 276, 6893–6896.
  • Gold, MR., Ingham, R.J., McLeod, Si., Christian, S.L., Scheid, M.P., Duronio, V., et al. (2000) "Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap! GTPase", Immunol. Rev., 176, 47–68.
  • Bichi, R., Shinton, S.A., Martin, ES., Koval, A., Calm, GA., Cesari, R., et al. (2002) "Human chronic lyimphocytic leukemia modeled in mouse by targeted TCLI expression", Proc. Natl. Acad. Sci. USA, 99, 6955–6960.
  • Laine, J., Kunstle, G., Obata, T., Sha, M., and Noguchi, M. (2000) "The protooncogene TCLI is an Akt kinase coactivator", MoL Cell., 6, 395–407.
  • Pekarsky, Y., Koval, A., Hallas, C., Bichi, R., Tresini, M., Malstrom, S., et al. (2000) "Tcll enhances Akt kinase activity and mediates its nuclear translocation", Proc. Natl. Acad. Sci. USA, 97, 3028 — 3033.
  • Bernal, A., Pastore, RD., Asgary, Z., Keller, S.A., Cesarman, E., Liou, H.C., et al. (2001) "Survival of leukemic B cells promoted by engagement of the antigen receptor", Blood, 98, 3050— 3057.
  • Hill, MM., Feng, J. and Hemmings, BA. (2002) "Identification of a plasma membrane Raft-associated PKB 5er473 kinase activity that is distinct from ILK and PDK1", Curr. Biol., 12, 1251–1255.
  • Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocici, E., Murakami, K., Au, P.Y., et al. (2003) "Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity", Genes Dev., 17, 883–895.
  • Wang, S.S., Esplin, ED., Li, J.L., Huang, L., Gazdar, A., Minna, J., et al. (1998) "Alterations of the PPP2R1B gene in human lung and colon cancer", Science, 282, 284 — 287.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.