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Original Article: Research

The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability

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Pages 1207-1216 | Received 05 Apr 2005, Published online: 03 Aug 2009

References

  • Penn I, Hammond W, Brettschneider L, Starzl TE. Malignant lymphomas in transplantation patients. Transplant Proc 1969;1(1):106–112.
  • Paya CV, Fung ll Nalesnik MA, Kieff E, Green M, Gores G, Habermann TM, Wiesner PH, Swinnen JL, Woodle ES, Bromberg JS. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Con-sensus Development Meeting. Transplantation 1999;68 (1O):1517— 1515.
  • Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 1995; 345(8941): 9–13.
  • Berke G. The CTL's kiss of death. Cell 1995;81 (1):9 —12
  • Henkart PA. Lymphocyte-mediated cytotoxicity: two path-ways and multiple effector molecules. Immunity 1994;1(5): 343 — 348.
  • Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata V. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994;265(7):528— 532.
  • Schmaltz C, Alpdogan O, Homdasch KJ, Muriglan SJ, Kappel BJ, Teshima T. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood 2001; 97 (9):2886 — 2895.
  • Nagata S. Apoptosis by death factor. Cell 1997;88(3):355 — 365.
  • Smyth MJ, Trapani JA. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 1995;16(5):202–206.
  • Trapani JA, Jans P, Smyth MJ, Froehlich CJ, Williams EA, Sutton VR. Death Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Differ 1998;5(3):488–496.
  • Zamzami N, Kroemer G. Apoptosis: mitochondrial mem-brane permeabilization - the (w)hole story? Curr Biol 2003;21(2):71–73.
  • Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001;2(1): 63–67.
  • Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M. Tumorcidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature Med 1999;5(2):157–163.
  • Braun MY, Lowin B, French L, Archa-Obea H, Tschopp J. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J Exp Med 1996;183(1):657–661.
  • Thomas WD, Hersey P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in FAS ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. J Immunol 1998;161(5):2195–2200.
  • Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102(3): 33–42.
  • Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nature Cell Biol 2000;2(3):156–162.
  • Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000;10(3):369–377.
  • Yasukawa M, Ohminami H, Arai J, Kasahara Y, Kasahara Y, Ishida Y, Fujita S. Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4( +) as well as CD8( +) cytotoxic T lymphocytes in humans. Blood 2000;95(7):2352–2355.
  • Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 1999; 274(32):22532–22538.
  • Griillich C, Sullards MC, Fuks Zvi, Merrill AH Jr, Kolesnick R. CD95 (Fas/APO-1) signals ceramide generation indepen-dent of the effector stage of apoptosis. J Biol Chem 2000;275(12):8650–8656.
  • Beatty PR, Krams SM, Martinez OM. Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines. J Immunol 1997;158(3):4045–4049.
  • Kroemer G, Reed JC. Mitochondrial control of cell death. Nature Med 2000;6(3):513–519
  • Heiskanen, KM, Bhat MB, Wang HW, Ma jj, Nieminen AL. Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J Biol Chem 1999;274(3): 5654–5658.
  • Bernardi P, Scorrano L, Colonna R, Petronilli V, Di Lisa F. Mitochondria and cell death - Mechanistic aspects and methodological issues. Eur J Biochem 1999;264(2):687–701.
  • Kataoka T, Shinohara N, Takayama H, Takaku K, Kondo S, Yonehara S. Concanamycin A, a powerful tool for character-ization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol 1996;156(3):3678–3686.
  • Pepe MS. The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford: Oxford University Press; 2003, pp. 126–135.
  • Waterhouse NJ, Clarke CJ, Sedelies KA, Teng MW, Trapani JA. Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol. 2004;68(6):1033–1040.
  • Trapani JA, Sutton VR. Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol. 2003; 15(5):533–543.
  • Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thomberry NA. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 1998;273(14):32608–32613.
  • Watanabe T, Sakai Y, Miyawaki S, Shimizu A, Koiwai O, Ohno K. A molecular genetic linkage map of mouse chromosome 19, including the lpr, Ly-44, and Tdt genes. Biochem Genet 1991;29(3):325–335.
  • Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci USA 1994;91(6):10854–10858.
  • Smyth MJ, Street SE, Trapani JA. Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol. 2003;171(2):515–518.
  • Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem. 1998 Jun 15;254(3):439–459.
  • Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994;76(13):969–976.
  • Peter ME, Krammer PH. The CD95(AP0-1/Fas) DISC and beyond. Cell Death Differ 2003;10(9):26–35.
  • Nicholson DW, Thomberry NA. Apoptosis. Life and death decisions. Science 2003;299(8): 214–215.
  • Heibein JA, Goping IS, Barry M, Pinkoski MJ, Shore GC, Green DR. Granzyme B-mediated cytochrome c release is regulated by the Bc1-2 family members bid and Bax. J Exp Med 2000;192(13):1391–1402.
  • Pardo J, Perez-Galan P, Gamen S, Marzo I, Monleon I, Kaspar AA, Susin SA, Kroemer G, Krensky AM, Naval J, Anel A. A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis. J Immunol 2001;167(3): 1222–1229.
  • Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31–38.
  • Barnhart BC, Alappat EC, Peter ME. The CD95 typeIttypen model. Semin Immunol 2003; 15(3):185–193
  • Dirsch VM, Muller IM, Eichhorst ST, Pettit GR, Kamano Y, Inoue M, Xu JP, Ichihara Y, Wanner G, Vollmar AM. Cephalostatin 1 selectively triggers the release of Smac/ DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Res 2003;63 (24):8869–8876.
  • Chiriva-Intemati M, Du J, Cannon M, Barlogie B, Yi Q. Myeloma-reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway. Br J Haematol 2001;112(2):410–420.
  • Porakishvili N, Kardava L, Jewell AP, Yong K, Glennie MJ, Akbar A, Lydyard PM. Cytotoxic CD4 + T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. Haematologica 2004;89(4):35–443.

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