68
Views
2
CrossRef citations to date
0
Altmetric
Original

Poor ex vivo induction of T-cell responses to idiotype or tumor cell lysate-pulsed autologous dendritic cells in advanced pre-treated multiple myeloma

, , , , , , , , , & show all
Pages 1340-1347 | Received 17 Jul 2005, Accepted 17 Oct 2005, Published online: 01 Jul 2009

References

  • Cao H, Vergé V, Baron C, Martinache C, Leon A, Scholl S, et al. In vitro generation of dendritic cells from human blood monocytes of healthy donors and patients in experimental conditions compatible for their use in cell therapy. J Hematother Stem Cell Res 2000; 9: 183–194
  • Garderet L, Cao H, Salamero J, Vergé V, Tisserand E, Scholl S, et al. In vitro production of dendritic cells from human blood monocytes for therapeutic use. J Hematother Stem Cell Res 2001; 10: 553–567
  • Banchereau J, Steinman R M. Dendritic cells and the control of immunity. Nature 1998; 392: 245–252
  • Bataille R, Harousseau J. Multiple myeloma. N Engl J Med 1994; 330: 484–489
  • Child J A, Morgan G J, Davies F E, Owen R G, Bell S E, Hawkins K, et al. High-dose chemotherapy with haematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003; 348: 1875–1883
  • Barlogie B, Shaughnessy J, Tricot G, Jacobson J, Zangari M, Anaissie E, et al. Treatment of multiple myeloma. Blood 2004; 103: 20–32
  • Alyea E, Weller E, Schlossman R, Canning C, Webb I, Doss D, et al. T-cell depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect. Blood 2001; 98: 934–939
  • Segeren C M, Sonneveld P, Van der Holdt B, Vellenga E, Croockewit A J, Verhoef G E, et al. Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study. Blood 2003; 101: 2144–2151
  • Raje N, Anderson K. Thalidomide-a revival story. N Engl J Med 1999; 341: 1606–1609
  • Richardson P G, Schlossman R L, Weller E, Hideshima T, Mitsiades C, Davies F, et al. Immunomodulary drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002; 100: 3063–3067
  • Richardson P G, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin D, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348: 2609–2617
  • Stevenson F K, Anderson K C. Preparing the ground for vaccination against multiple myeloma. Immunology Today 2000; 21: 171
  • Reichardt V L, Okada C Y, Liso A, Benike C J, Stockerl-Goldstein K E, Engleman E G, et al. Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma: a feasibility study. Blood 1999; 93: 2411–2419
  • Massaia M, Borrione P, Battaglio S, Mariani S, Beggiato E, Napoli P, et al. Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy. Blood 1999; 94: 673–683
  • Milazzo C, Reichardt V L, Muller M R, Grunebach F, Brossart P. Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA. Blood 2003; 101: 977–982
  • Hayashi T, Hideshima T, Akiyama M, Raje N, Richardson P, Chauhan D, et al. Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. Blood 2003; 102: 1435–1442
  • Dhodapkar M V, Krasovsky J, Olson K. T cells from the tumor microenvironment of patients with progressive myeloma can generate strong, tumor-specific cytolytic responses to autologous, tumor-loaded dendritic cells. Proc Nat Acad Sci USA 2002; 99: 13009–13013
  • Wen Y J, Min R, Tricot G, Barlogie B, Qing Y. Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy. Blood 2002; 99: 3280–3285
  • Lopez M, Fechtenbaum J, David B, Martinachc C, Chokri M, Canepa S, et al. Adoptive immunotherapy with activated macrophages grown in vitro from blood monocytes in cancer patients: a pilot study. J Immunother 1992; 11: 209–217
  • Kaiser A, Bercovici N, Abastado J P, Nardin A. Naïve CD8 T cells recruitment and proliferation are dependent on stage of dendritic cell maturation. Eur J Immunol 2003; 33: 162–171
  • Moreau-Aubry A, Le Guiner S, Labarriere N, Gesnel M C, Jotereau F, Breathnach R. A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma. J Exp Med 2000; 191: 1617–1624
  • Pellat-Deceunynck C, Jego G, Harousseau J -L, Vié H, Bataille R. Isolation of HLA-I-restricted cytotoxic T lymphocytes against autologous myeloma cells. Clin Cancer Res 1999; 5: 705–709
  • Yi Q, Osterborg A, Bergerbrant S, Mellstedt H, Holm G, Lefvert A K. Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies. Blood 1995; 86: 3043
  • Bogen B. Peripheral T-cell tolerance as tumor escape mechanism: deletion of CD4 + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur J Immunol 1996; 26: 2671–2679
  • Ratta M, Fagnoni F, Curti A, Vescovini R, Sansoni P, Oliviero B. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6. Blood 2002; 100: 230–237
  • Zhou Y, Bosch M L, Salgaller M L. Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity. J Immunother 2002; 25: 289–303
  • King C A, Spellerberg M B, Zhu D, Rice J, Sahota S S, Thompsctt A R, et al. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat Med 1998; 4: 1281–1286
  • Raje N, Hideshima T, Davies F E, Chauhan D, Treon S P, Young G, et al. Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma. Br J Hematol 2004; 125: 343–352
  • Hsu F J, Benike C, Fagnoni F, Liles T M, Czerwinski D, Taidi B, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med 1996; 2: 52–58
  • Fiore F, Nuschak B, Peola S, Mariani S, Muraro M, Foglietta M, et al. Exposure to myeloma cell lysates affects the immune competence of dendritic cells and favours the induction of Tr1-like regulatory T cells. Eur J Immunol 2005; 35: 1155–1163
  • Van baren N, Brasseur F, Godelaine D, Hames G, Ferrant A, Lehmann F, et al. Genes encoding tumor-specific antigens are expressed in human myeloma cells. Blood 1999; 94: 1156–1164
  • Pellat-Deceunynck C, Mellerin M P, Labarrière N, Jego G, Moreau-Aubry A, Harousseau J L, et al. The cancer germ-line genes MAGE-1, MAGE-3 and PRAME are commonly expressed by human myeloma cells. Eur J Immunol 2000; 30: 803–809
  • Milazzo C, Reichardt V L, Muller M R, Grunebach F, Brossart P. Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA. Blood 2003; 101: 977–982
  • Orsini E, Bellucci R, Alyea E P, Schlossman R, Canning C, McLaughlin S, et al. Expansion of tumor-specific CD8 + T cell clones in patients with relapsed myeloma after donor lymphocyte infusion. Cancer Res 2003; 63: 2561–2568
  • Osterborg A, Henriksson L, Mellstedt H. Idiotype immunity (natural and vaccine-induced) in early stage multiple myeloma. Acta Oncologica 2000; 39: 797–800
  • Dhodapkar M V, Krasovsky J, Osman K, Geller M D. Vigorous premalignancy-specific effector T cell respons in the bone marrow of patients with monoclonal gammopathy. J Exp Med 2003; 198: 1753–1757
  • Pellat-Deceunynck. Tumour-associated antigens in multiple myeloma. Br J Haematol 2003; 120: 3–9
  • De Angelis C, Drazen J M, Frizelle F A, Haug C, Hoey J, Horton R, et al. Clinical trial registration: a statement from the international committee of medical journal editors. N Engl J Med 2004; 351: 1250–1251
  • Harrison S J, Cook G. Immunotherapy in multiple myeloma—possibility or probability?. Br J Haematol 2005; 130: 344–362

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.