231
Views
18
CrossRef citations to date
0
Altmetric
Original

IL-7 in allogeneic transplant: Clinical promise and potential pitfalls

, & , MD
Pages 1222-1228 | Accepted 21 Dec 2005, Published online: 01 Jul 2009

References

  • Pallera A M, Schwartzberg L S. Managing the toxicity of hematopoietic stem cell transplant. Journal of Supportive Oncology 2004; 2: 223–237
  • Appelbaum F R. Haematopoietic cell transplantation as immunotherapy. Nature 2001; 411: 385–389
  • Horowitz M M, Gale R P, Sondel P M, Goldman J M, Kersey J, Kolb H J, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555–562
  • Mcsweeney P A, Niederwieser D, Shizuru J A, Sandmaier B M, Molina A J, Maloney D G, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 2001; 97: 3390–3400
  • Laughlin M J, Eapen M, Rubinstein P, Wagner J E, Zhang M J, Champlin R E, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Eng J Med 2004; 351: 2265–2275
  • Baron F, Storb R. Allogeneic hematopoietic cell transplantation as treatment for hematological malignancies: a review. Springer Seminars in Immunopathology 2004; 26: 71–94
  • Sehn L H, Alyea E P, Weller E, Canning C, Lee S, Ritz J, et al. Comparative outcomes of t-cell-depleted and non-t-cell-depleted allogeneic bone marrow transplantation for chronic myelogenous leukemia: Impact of donor lymphocyte infusion. J Clin Oncol 1999; 17: 561–568
  • Roux E, Dumont-Girard F, Starobinski M, Siegrist C A, Helg C, Chapuis B, et al. Recovery of immune reactivity after t-cell-depleted bone marrow transplantation depends on thymic activity. Blood 2000; 96: 2299–2303
  • Hakim F T, Memon S A, Cepeda R, Jones E C, Chow C K, Kasten-Sportes C, et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest 2005; 115: 930–939
  • Chung B, Barbara-Burnham L, Barsky L, Weinberg K. Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation. Blood 2001; 98: 1601–1606
  • Min D, Taylor P A, Panoskaltsis-Mortari A, Chung B, Danilenko D M, Farrell C, et al. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral t-cell reconstitution after bone marrow transplantation. Blood 2002; 99: 4592–4600
  • Toki J, Adachi Y, Jin T, Fan T, Takase K, Lian Z, et al. Enhancement of il-7 following irradiation of fetal thymus. Immunobiology 2003; 207: 247–258
  • Seemayer T A, Lapp W S, Bolande R P. Thymic involution in murine graft-versus-host reaction. Epithelial injury mimicking human thymic dysplasia. Am J Pathol 1977; 88: 119–133
  • Bolotin E, Smogorzewska M, Smith S, Widmer M, Weinberg K. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 1996; 88: 1887–1894
  • Mackall C L, Fleisher T A, Brown M R, Andrich M P, Chen C C, Feuerstein I M, et al. Age, thymopoiesis, and cd4+ t-lymphocyte regeneration after intensive chemotherapy. N Eng J Med 1995; 332: 143–149
  • Broers A E, Posthumus-Van Sluijs S J, Spits H, Van Der Holt B, Lowenberg B, Braakman E, et al. Interleukin-7 improves t-cell recovery after experimental t-cell-depleted bone marrow transplantation in t-cell-deficient mice by strong expansion of recent thymic emigrants. Blood 2003; 102: 1534–1540
  • Fry T J, Mackall C L. The many faces of il-7: From lymphopoiesis to peripheral t cell maintenance. J Immunol 2005; 174: 6571–6576
  • Brochu S, Rioux-Masse B, Roy J, Roy D C, Perreault C. Massive activation-induced cell death of alloreactive t cells with apoptosis of bystander postthymic t cells prevents immune reconstitution in mice with graft-versus-host disease. Blood 1999; 94: 390–400
  • Namen A E, Lupton S, Hjerrild K, Wignall J, Mochizuki D Y, Schmierer A, et al. Stimulation of b-cell progenitors by cloned murine interleukin-7. Nature 1988; 333: 571–573
  • Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, et al. Interleukin 7 production and function in stromal cell-dependent b cell development. J Exp Med 1989; 170: 333–338
  • Peschon J J, Morrissey P J, Grabstein K H, Ramsdell F J, Maraskovsky E, Gliniak B C, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180: 1955–1960
  • Lu H, Zhao Z, Kalina T, Gillespy T, 3rd, Liggitt D, Andrews R G, et al. Interleukin-7 improves reconstitution of antiviral cd4 t cells. Clin Immunol 2005; 114: 30–41
  • Fry T J, Christensen B L, Komschlies K L, Gress R E, Mackall C L. Interleukin-7 restores immunity in athymic t-cell-depleted hosts. Blood 2001; 97: 1525–1533
  • Abdul-Hai A, Ben-Yehuda A, Weiss L, Friedman G, Zakay-Rones Z, Slavin S, et al. Interleukin-7-enhanced cytotoxic t lymphocyte activity after viral infection in marrow transplanted mice. Bone Marrow Transplant 1997; 19: 539–543
  • Yewdell J W, Del Val M. Immunodominance in tcd8+ responses to viruses: cell biology, cellular immunology, and mathematical models. Immunity 2004; 21: 149–153
  • Storek J, Gillespy T, 3rd, Lu H, Joseph A, Dawson M A, Gough M, et al. Interleukin-7 improves cd4 t-cell reconstitution after autologous cd34 cell transplantation in monkeys. Blood 2003; 101: 4209–4218
  • Nugeyre M T, Monceaux V, Beq S, Cumont M C, Ho Tsong Fang R, Chene L, et al. Il-7 stimulates t cell renewal without increasing viral replication in simian immunodeficiency virus-infected macaques. J Immunol 2003; 171: 4447–4453
  • Fry T J, Moniuszko M, Creekmore S, Donohue S J, Douek D C, Giardina S, et al. Il-7 therapy dramatically alters peripheral t-cell homeostasis in normal and siv-infected nonhuman primates. Blood 2003; 101: 2294–2299
  • Van Roon J A, Verweij M C, Wijk M W, Jacobs K M, Bijlsma J W, Lafeber F P. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of cd4(+) t cells and macrophages. Arthritis & Rheumatics 2005; 52: 1700–1710
  • Van Roon J A, Glaudemans K A, Bijlsma J W, Lafeber F P. Interleukin 7 stimulates tumour necrosis factor alpha and th1 cytokine production in joints of patients with rheumatoid arthritis. Annals of Rheumatic Diseases 2003; 62: 113–119
  • De Benedetti F, Massa M, Pignatti P, Kelley M, Faltynek C R, Martini A. Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. J Rheumatol 1995; 22: 1581–1585
  • Traggiai E, Biagioli T, Rosati E, Ballerini C, Mazzanti B, Ben Nun A, et al. Il-7-enhanced t-cell response to myelin proteins in multiple sclerosis. J Neuroimmunol 2001; 121: 111–119
  • Neidhart M, Bruhlmann P, Gay S, Michel B A. Activation of cd4+ and cd8+ t-lymphocytes in bone marrow associated with reduced erythropoiesis in patients with chronic inflammation and anaemia. Schweizerische Medizinische Wochenschrift 1998; 128: 1618–1623
  • Alpdogan O, Schmaltz C, Muriglan S J, Kappel B J, Perales M A, Rotolo J A, et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 2001; 98: 2256–2265
  • Alpdogan O, Muriglan S J, Eng J M, Willis L M, Greenberg A S, Kappel B J, et al. Il-7 enhances peripheral t cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest 2003; 112: 1095–1107
  • Sinha M L, Fry T J, Fowler D H, Miller G, Mackall C L. Interleukin 7 worsens graft-versus-host disease. Blood 2002; 100: 2642–2649
  • Appay V, Dunbar P R, Callan M, Klenerman P, Gillespie G M, Papagno L, et al. Memory cd8+ t cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8: 379–385
  • Boursalian T E, Golob J, Soper D M, Cooper C J, Fink P J. Continued maturation of thymic emigrants in the periphery. Nat Immunol 2004; 5: 418–425
  • Schluns K S, Kieper W C, Jameson S C, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory cd8 t cells in vivo. Nat Immunol 2000; 1: 426–432
  • Moniuszko M, Fry T, Tsai W P, Morre M, Assouline B, Cortez P, et al. Recombinant interleukin-7 induces proliferation of naive macaque cd4+ and cd8+ t cells in vivo. Journal of Virology 2004; 78: 9740–9749
  • Kaech S M, Tan J T, Wherry E J, Konieczny B T, Surh C D, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector cd8 t cells that give rise to long-lived memory cells. Nat Immunol 2003; 4: 1191–1198
  • Van Leeuwen E M, De Bree G J, Remmerswaal E B, Yong S L, Tesselaar K, Ten Berge I J, et al. Il-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human cd8+ t cells. Blood 2005; 106: 2091–2098
  • Lang K S, Recher M, Navarini A A, Harris N L, Lohning M, Junt T, et al. Inverse correlation between il-7 receptor expression and cd8 t cell exhaustion during persistent antigen stimu- lation. Euro J Immunol 2005; 35: 738–745
  • Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, et al. Loss of cd127 expression defines an expansion of effector cd8+ t cells in hiv-infected individuals. J Immunol 2005; 174: 2900–2909

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.