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Original

A precise pharmacodynamic study showing the advantage of a marked reduction in cardiotoxicity in continuous infusion of doxorubicin

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Pages 1599-1607 | Received 09 Aug 2005, Accepted 02 Jan 2006, Published online: 01 Jul 2009

References

  • Davis H L, Davis T E. Daunorubicin and adriamycin in cancer treatment: an analysis of their roles and limitations. Cancer Treat Rep 1979; 63: 809–815
  • Skipper H E, Schabel F M, Jr, Mellett L B, Montgomery J A, Wilkoff L J, Lloyd H H, Brockman R W. Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules. Cancer Chemother Rep 1970; 54: 431–450
  • Minow R A, Benjamin R S, Lee E T, Gottlieb J A. Adriamycin cardiomyopathy—risk factors. Cancer 1977; 39: 1397–1402
  • Von Hoff D D, Layard M W, Basa P, Davis H L, Jr, Von Hoff A L, Rozencweig M, Muggia F M. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 1979; 91: 710–717
  • Legha S S, Benjamin R S, Mackay B, Yap H Y, Wallace S, Ewer M, Blumenschein G R, Freireich E J. Adriamycin therapy by continuous intravenous infusion in patients with metastatic breast cancer. Cancer 1982; 49: 1762–1766
  • Langebrake C, Reinhardt D, Ritter J. Minimising the long-term adverse effects of childhood leukaemia therapy. Drug Saf 2002; 25: 1057–1077
  • Bielack S S, Erttmann R, Winkler K, Landbeck G. Doxorubicin: effect of different schedules on toxicity and anti-tumor efficacy. Eur J Cancer Clin Oncol 1989; 25: 873–882
  • Bielack S S, Erttmann R, Kempf-Bielack B, Winkler K. Impact of scheduling on toxicity and clinical efficacy of doxorubicin: what do we know in the mid-nineties?. Eur J Cancer 1996; 32A: 1652–1660
  • Robert J. Continuous infusion or intravenous bolus: what is the rationale for doxorubicin administration?. Cancer Drug Deliv 1987; 4: 191–199
  • Iarussi D, Indolfi P, Casale F, Martino V, Di Tullio M T, Calabro R. Anthracycline-induced cardiotoxicity in children with cancer: strategies for prevention and management. Paediatr Drugs 2005; 7: 67–76
  • Kishi S, Goto N, Nakamura T, Ueda T. Evaluation of cell-killing effects of 1-beta-D-arabinofuranosylcytosine and daunorubicin by a new computer-controlled in vitro pharmacokinetic simulation system. Cancer Res 1999; 59: 2629–2634
  • Nishimura M, Kumamoto Y, Shibuya A, Hirose T, Tsukamoto T, Ohya S. [An in vitro study on the treatment of complicated cystitis using an automatic simulator]. Kansenshogaku Zasshi 1990; 64: 1004–1012
  • Benjamin R S, Riggs C E, Jr, Bachur N R. Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Cancer Res 1977; 37: 1416–1420
  • Dorr R T, Bozak K A, Shipp N G, Hendrix M, Alberts D S, Ahmann F. In vitro rat myocyte cardiotoxicity model for antitumor antibiotics using adenosine triphosphate/protein ratios. Cancer Res 1988; 48: 5222–5227
  • Tanaka M, Ito H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, Marumo F, Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res 1994; 75: 426–433
  • Haddad J, Decker M L, Hsieh L C, Lesch M, Samarel A M, Decker R S. Attachment and maintenance of adult rabbit cardiac myocytes in primary cell culture. Am J Physiol 1988; 255: C19–C27
  • VanWinkle W B, Snuggs M B, Buja L M. Cardiogel: a biosynthetic extracellular matrix for cardiomyocyte culture. In Vitro Cell Dev Biol Anim 1996; 32: 478–485
  • Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M. Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration – time product. Cancer Chemother Pharmacol 1988; 21: 185–190
  • Ozawa S, Sugiyama Y, Mitsuhashi J, Inaba M. Kinetic analysis of cell killing effect induced by cytosine arabinoside and cisplatin in relation to cell cycle phase specificity in human colon cancer and Chinese hamster cells. Cancer Res 1989; 49: 3823–3828
  • Chervinsky D S, Wang J J. Uptake of adriamycin and daunomycin in L1210 and human leukemia cells: a comparative study. J Med 1976; 7: 63–79
  • Bachur N R, Steele M, Meriwether W D, Hildebrand R C. Cellular pharmocodynamics of several anthrocycline antibiotics. J Med Chem 1976; 19: 651–654
  • Paul C, Liliemark J, Tidefelt U, Gahrton G, Peterson C. Pharmacokinetics of daunorubicin and doxorubicin in plasma and leukemic cells from patients with acute nonlymphoblastic leukemia. Ther Drug Monit 1989; 11: 140–148
  • Claycomb W C, Bradshaw H D, Jr. Acquisition of multiple nuclei and the activity of DNA polymerase alpha and reinitiation of DNA replication in terminally differentiated adult cardiac muscle cells in culture. Dev Biol 1983; 99: 331–337
  • Oparil S, Bishop S P, Clubb F J, Jr. Myocardial cell hypertrophy or hyperplasia. Hypertension 1984; 6: 38–43
  • Iwamoto Y, Hansen I L, Porter T H, Folkers K. Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity. Biochem Biophys Res Commun 1974; 58: 633–638
  • Doroshow J H, Locker G Y, Myers C E. Experimental animal models of adriamycin cardiotoxicity. Cancer Treat Rep 1979; 63: 855–860
  • Seraydarian M W, Artaza L, Goodman M F. Adriamycin: effect on mammalian cardiac cells in culture. I. Cell population and energy metabolism. J Mol Cell Cardiol 1977; 9: 375–382
  • Gosalvez M, van Rossum G D, Blanco M F. Inhibition of sodium-potassium-activated adenosine 5′-triphosphatase and ion transport by adriamycin. Cancer Res 1979; 39: 257–261
  • Kawasaki N, Lee J D, Shimizu H, Ueda T. Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure. J Card Fail 1996; 2: 293–299
  • Billingham M E, Mason J W, Bristow M R, Daniels J R. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep 1978; 62: 865–872
  • Jaenke R S, Fajarado D F. Adriamycin-induced myocardial lesions. Report of a workshop. Am J Surg Pathol 1977; 1: 55–60
  • Arola O J, Saraste A, Pulkki K, Kallajoki M, Parvinen M, Voipio-Pulkki L M. Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis. Cancer Res 2000; 60: 1789–1792
  • Haq M M, Legha S S, Choksi J, Hortobagyi G N, Benjamin R S, Ewer M, Ali M. Doxorubicin-induced congestive heart failure in adults. Cancer 1985; 56: 1361–1365
  • Legha S S, Benjamin R S, Mackay B, Ewer M, Wallace S, Valdivieso M, Rasmussen S L, Blumenschein G R, Freireich E J. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982; 96: 133–139

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