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Original

Clonal lymphocytic populations in Philadelphia-negative chronic myeloproliferative disorders: is the T-cell clonality of ‘undetermined’ significance (TCUS) linked to a worse clinical outcome?

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Pages 2351-2358 | Received 16 Mar 2006, Accepted 24 Apr 2006, Published online: 01 Jul 2009

References

  • World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, E S Jaffe, N L Harris, H Stein, J W Vardiman. IARC Press, Lyon 2001
  • Ruggeri M, Finazzi G, Tosetto A, Riva S, Rodeghiero F, Barbui T. No treatment for low-risk thrombocythaemia: results from a prospective study. Br J Haematol 1998; 103: 772–777
  • Guardiola P, Anderson J E, Bandini G, Cervantes F, Runde V, Arcese W, et al. Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. Blood 1999; 93: 2831–2838
  • Anderson J E, Tefferi A, Craig F, Holmberg L, Chauncey T, Appelbaum F R, et al. Myeloablation and autologous peripheral blood stem cell rescue results in hematologic and clinical responses in patients with myeloid metaplasia with myelofibrosis. Blood 2001; 98: 586–593
  • Rozman C, Giralt M, Feliu E, Rubio D, Cortes M T. Life expectancy of patients with chronic nonleukemic myeloproliferative disorders. Cancer 1991; 67: 2658–2663
  • Tefferi A. The Philadelphia chromosome negative chronic myeloproliferative disorders: a practical overview. Mayo Clin Proc 1998; 73: 1177–1184
  • Brodmann S, Passweg J R, Gratwohl A, Tichelli A, Skoda R C. Myeloproliferative disorders: complications, survival and causes of death. Ann Hematol 2000; 79: 312–318
  • Tefferi A, Gilliland D G. The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis. Mayo Clin Proc 2005; 80: 947–958
  • Macintyre E A, Delabesse E. Molecular approaches to the diagnosis and evaluation of lymphoid malignancies. Semin Hematol 1999; 36: 373–389
  • Collins R D. Is clonality equivalent to malignancy: specifically, is immunoglobulin gene rearrangement diagnostic of malignant lymphoma?. Hum Pathol 1997; 28: 850–861
  • Bauermeister D E. Quantitation of bone marrow reticulin – a normal range. Am J Clin Pathol 1971; 56: 24–31
  • Miettinen M, Lasota J. Polymerase chain reaction based gene rearrangement studies in the diagnosis of follicular lymphoma – performance in formaldehyde-fixed tissue and application in clinical problem cases. Pathol Res Pract 1997; 193: 9–19
  • Wan J H, Trainor K J, Brisco M J, Morley A A. Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction. J Clin Pathol 1990; 43: 888–890
  • Rakozy C K, Mohamed A N, Vo T D, Khatib G, Long P M, Eilender D, et al. CD56+/CD4+ lymphomas and leukemias are morphologically, immunophenotypically, cytogenetically, and clinically diverse. Am J Clin Pathol 2001; 116: 168–176
  • Dadej K, Gaboury L, Lamarre L, Petorin C, Seguin C, Cadotte M, et al. The value of clonality in the diagnosis and follow-up of patients with cutaneous T-cell infiltrates. Diagn Mol Pathol 2001; 10: 78–88
  • Hallen J. Frequency of ‘abnormal’ serum globulins (M-components) in the aged. Acta Med Scand 1963; 173: 737–744
  • Aman P, Mellstedt H. The leukemic B-cell population of patients with monoclonal lymphocytosis of undetermined significance (MLUS) are functionally distinct from the chronic lymphocytic leukemia (CLL) derived cell population. Leuk Res 1991; 15: 715–719
  • Marti G E, Rawstron A C, Ghia P, Hillmen P, Houlston R S, Kay N, et al. The International Familial CLL Consortium. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005; 130: 325–332
  • Posnett D N, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to ‘benign monoclonal gammapathy’. J Exp Med 1994; 179: 609–618
  • Lantelme E, Granziero L, Angman L, Giachino C. Clonal predominance, but preservation of a polyclonal reservoir, in the normal alpha beta T-cell repertoire. Hum Immunol 1997; 53: 49–56
  • Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth J A, Sinclair A J, et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984–1992
  • Delfau-Larue M H. Peripheral blood T-cell clonality of no cutaneous T-cell lymphoma diagnostic value. Blood 2001; 98: 248
  • Schwab R, Szabo P, Manavalan J S, Weksler M E, Posnett D N, Pannetier C, et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 1997; 158: 4493–4499
  • Monteiro J, Hingorani R, Choi I H, Silver J, Pergolizzi R, Gregersen P K. Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases. Mol Med 1995; 1: 614–624
  • Fitzgerald J E, Ricalton N S, Meyer A C, West S G, Kaplan H, Behrendt C, et al. Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 1995; 154: 3538–3547
  • Manfras B J, Weidenbach H, Beckh K H, Kern P, Moller P, Adler G, et al. Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy. J Clin Immunol 2004; 24: 258–271
  • Rittner H L, Zettl A, Jendro M C, Bartz-Bazzanella P, Goronzy J J, Weyand C M. Multiple mechanisms support oligoclonal T-cell expansion in rheumatoid synovitis. Mol Med 1997; 3: 452–465
  • Plonquet A, Gherardi R K, Creange A, Antoine J C, Benyahia B, Grisold W, et al. Oligoclonal T-cells in blood and target tissues of patients with anti-Hu syndrome. J Neuroimmunol 2002; 122: 100–105
  • Risitano A M, Maciejewski J P, Green S, Plasilova M, Zeng W, Young N S. In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing. Lancet 2004; 364: 355–364
  • Delfau-Larue M H, Laroche L, Wechsler J, Lepage E, Lahet C, Asso-Bonnet M, et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000; 96: 2987–2992
  • Gniadecki R, Lukowsky A. Monoclonal T-cell dyscrasia of undetermined significance associated with recalcitrant erythroderma. Arch Dermatol 2005; 141: 361–367
  • Gherardi R K, Farcet J P, Creange A, Claudepierre P, Malapert D, Authier F J, et al. Dominant T-cell clones of unknown significance in patients with idiopathic sensory neuropathies. Neurology 1998; 51: 384–389
  • Serrano D, Becker K, Cunningham-Rundles C, Mayer L. Characterization of the T cell receptor repertoire in patients with common variable immunodeficiency: oligoclonal expansion of CD8(+) T cells. Clin Immunol 2000; 97: 248–258
  • Isobe T, Tanimoto T E, Nakaji G, Miyamoto T, Yamasaki S, Takase K, Numata A, et al. Autoimmune thrombocytopenia with clonal expansion of CD8-positive T cells after autologous peripheral blood stem cell transplantation for diffuse large B-cell lymphoma. Bone Marrow Transplant 2005; 35: 315–316
  • Matsutani T, Ohashi Y, Yoshioka T, Tsuruta Y, Doi H, Satomi S, et al. Skew in T-cell receptor usage and clonal T-cell expansion in patients with chronic rejection of transplanted kidneys. Transplantation 2003; 75: 398–407
  • Serrano D, Monteiro J, Allen S L, Kolitz J, Schulman P, Lichtman S M, et al. Clonal expansion within the CD4 + CD57+ and CD8 + CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol 1997; 158: 1482–1489
  • Alatrakchi N, Farace F, Frau E, Carde P, Munck J N, Triebel F. T-cell clonal expansion in patients with B-cell lymphoproliferative disorders. J Immunother 1998; 21: 363–370
  • Epperson D E, Nakamura R, Saunthararajah Y, Melenhorst J, Barrett A J. Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process. Leuk Res 2001; 25: 1075–1083
  • Dhodapkar M V, Li C Y, Lust J A, Tefferi A, Phyliky R L. Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance?. Blood 1994; 84: 1620–1627
  • Dippel E, Klemke D, Hummel M, Stein H, Goerdt S. T-cell clonality of undetermined significance. Blood 2001; 98: 247–248
  • Macdonald D, Reiter A, Cross N C. The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. Acta Haematol 2002; 107: 101–107
  • Hernandez-Boluda J C, Cervantes F, Alvarez A, Lopez-Guillermo A, Montserrat E. Non-Hodgkin's lymphoma following untreated essential thrombocythemia. Leuk Lymphoma 2000; 36: 421–423
  • Baxter E J, Scott L M, Campbell P J, East C, Fourouclas N, Swanton S, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005; 365: 1054–1061
  • James C, Ugo V, Le Couedic J P, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005; 434: 1144–1148
  • Reeder T L, Bailey R J, Dewald G W, Tefferi A. Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia. Blood 2003; 101: 1981–1983
  • Lenz H J, Waller H D. Autoimmune hemolytic anemia in a patient with polycythemia vera: first description. Acta Haematol 1991; 85: 111
  • Szegedi G, Nagy G. Coincidence of autoimmune diseases and polycythemia vera. Haematologia (Budap) 1970; 4: 367–372
  • Duhrsen U, Augener W, Zwingers T, Brittinger G. Spectrum and frequency of autoimmune derangements in lymphoproliferative disorders: analysis of 637 cases and comparison with myeloproliferative diseases. Br J Haematol 1987; 67: 235–239

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