References
- Byrd J C, Stilgenbauer S, Flinn I W. Chronic lymphocytic leukemia. Hematology (Am So Hematol Educ Program) 2004; 1: 163–183
- Nakamura N, Kuze T, Hashimoto Y, Tasaki K, Hojo H, Sasaki Y, et al. Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms and B cell chronic lymphocytic leukemia in the Japanese population. Pathol Int 1999; 49: 595–600
- Moazzeni S M, Amirzargar A A, Shokri F. HLA antigens in Iranian patients with B cell chronic lymphocytic leukemia. Pathol Oncol Res 1999; 5: 142–145
- Tamura K, Sawada H, Izumi Y, Fukuda T, Utsunomiya A, Ikeda S, et al. Chronic lymphocytic leukemia (CLL) is rare, but the proportion of T-CLL is high in Japan. Eur J Haematol 2001; 67: 152–157
- Galton D A. The pathogenesis of chronic lymphocytic leukemia. Can Med Assoc J 1966; 94: 1005–1010
- Hamblin T. Chronic lymphocytic leukemia: one disease or two?. Ann Hematol 2002; 81: 299–303
- Cheson B D, Bennett J M, Grever M, Kay N, Keating M J, O'Brien S, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990–4997
- Pangalis G A, Vassilakopoulos T P, Dimopoulou M N, Siakantaris M P, Kontopidou F N, Angelopoulou M K. B-chronic lymphocytic leukemia: practical aspects. Hematol Oncol 2002; 20: 103–146
- Matsuda F, Ishii K, Bourvagnet P, Kuma K, Hayashida H, Miyata T, et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 1998; 188: 2151–2162
- Cook G P, Tomlinson I M. The human immunoglobulin VH repertoire. Immunol Today 1995; 16: 237–242
- Stewart A K, Schwartz R S. Immunoglobulin V region and B cell. Blood 1994; 83: 1717–1730
- Fraser N L, Rowley G, Field M, Stott D I. The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus. Arthritis Res Ther 2003; 5: R114–R121
- Maloum K, Davi F, Magnac C, Pritsch O, McIntyre E, Valensi F, et al. Analysis of VH gene expression in CD5+ and CD5− B cell chronic lymphocytic leukemia. Blood 1995; 86: 3883–3890
- Brezinschek H P, Brezinschek R I, Lipsky P E. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995; 155: 190–202
- Kraj P, Rao S P, Glas A M, Hardy R R, Milner E C, Silberstein L E. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol 1997; 158: 5824–5832
- Koiso H, Yamane A, Mitsui T, Matsushima T, Tsukamoto N, Murakami H, et al. Distinctive immunoglobulin VH gene usage in Japanese patients with CLL. Leukemia Res 2006; 30: 272–276
- Widhopf G F, II, Rassenti L Z, Toy T L, Gribben J G, Wierda W G, Kipps T J. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104: 2499–2504
- Mauerer K, Zahrieh D, Gorgun G, Li A, Zhou J, Ansen S, et al. Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukemia. Br J Haematol 2005; 129: 499–510
- Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen S L, et al. Chronic lymphocytic leukemia B cells express restricted set of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515–1525
- Rassenti L Z, Kipps T J. Lack of allelic exclusion in B-cell chronic lymphocytic leukemia. J Exp Med 1997; 185: 1435–1445
- Sakai A, Marti G E, Caporaso N, Pittaluga S, Touchman J W, Fend F, et al. Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL. Blood 2000; 95: 1413–1419
- Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764–1775
- Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K, et al. Subset with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879–2885
- Pasqualucci L, Neri A, Baldini L, Dalla-Favera R, Migliazza A. BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. Cancer Res 2000; 60: 5644–5648
- Nardini E, Neri F, Vicenzi E, Poli G, Capello D, Gaidano G, et al. Thymic function and immunoglobulin mutation genotype in B-cell chronic lymphocytic leukemia patients. Int J Cancer 2003; 107: 958–961
- Duke V M, Gandini D, Sherrington P D, Lin K, Heelan B, Amlot P, et al. VH gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia. Haematologica 2003; 88: 1259–1271
- Oscier D G, Thompsett A, Zhu D, Stevenson F K. Differential rates of somatic hypermutation in VH genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 1997; 89: 4153–4160
- Rai K R, Sawitsky A, Cronkite E P, Chanana A D, Levy R N, Pasternack B S. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219–234
- Molica S, De Rossi G, Luciani M, Levato D. Prognostic features and therapeutical approaches in B-cell chronic lymphocytic leukemia: an update. Haematologica 1995; 80: 176–193
- Gharagozlou S, Ghods R, Bahrami Z S, Roohi A, Jeddi-Tehrani M, Conti-Fine B M, et al. Characterization of human hybridoma clones isolated from hemophilia patients with specificity for different domains of coagulating factor VIII. Hum Antibodies 2003; 12: 67–76
- Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156–159
- Mikaelsson E, Danesh-Manesh A H, Luppert A, Jeddi-Tehrani M, Rezvany M R, Sharifian R A, et al. Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. Blood 2005; 105: 4828–4835
- Pritsch O, Troussard X, Magnac C, Mauro F R, Davi F, Payelle-Brogard B, et al. VH gene usage by family members affected with chronic lymphocytic leukaemia. Br J Haematol 1999; 107: 616–624
- Hamblin T J, Davis Z, Gardiner A, Oscier D G, Stevenson F K. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848–1854
- Messmer B T, Albesiano E, Messmer D, Chiorazzi N. The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood 2004; 103: 3490–3495
- Ikematsu W, Ikematsu H, Okamura S, Otsuka T, Harada M, Niho Y. Surface phenotype and Ig heavy-chain gene usage in chronic B cell leukemias: expression of myelomonocytic surface markers in CD5-chronic B cell leukemia. Blood 1994; 83: 2602–2610
- Rassenti L Z, Kohsaka H, Kipps T J. Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA. Ann NY Acad Sci 1995; 764: 463–473
- Johnson T A, Rassenti L Z, Kipps T J. IgVH1 Genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997; 158: 235–246
- Tobin G, Thunberg U, Johnson A, Thorn I, Soderberg O, Hultdin M, et al. Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262–2264
- Efremov D G, Ivanovski M, Siljanovski N, Pozzato G, Cevreska L, Fais F, et al. Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. Blood 1996; 87: 3869–3876
- Morton L M, Wang S S, Devesa S S, Hartge P, Weisenburger D D, Linet M S. Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood 2006; 107: 265–276
- Redaelli A, Laskin B L, Stephens J M, Botteman M F, Pashos C L. The clinical and epidemiological burden of chronic lymphocytic leukaemia. Eur J Cancer Care (Engl) 2004; 13: 279–287
- Ghiotto F, Fais F, Valetto A, Albesiano E, Hashimoto S, Dono M, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004; 113: 1008–1016
- Suarez F, Lortholary O, Hermine O, Lecuit M. Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood 2006; 107: 3034–3044
- Li H C, Stoicov C, Rogers A B, Houghton J. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol 2006; 12: 363–371
- Shokri F, Mageed R A, Kitas G D, Katsikis P, Moutsopoulos H M, Jefferis R. Quantification of cross-reactive idiotype-positive rheumatoid factor produced in autoimmune rheumatic diseases. An indicator of clonality and B cell proliferative mechanisms. Clin Exp Immunol 1991; 85: 20–27
- Shokri F, Mageed R A, Maziak B R, Talal N, Amos N, Williams B D, et al. Lymphoproliferation in primary Sjogren's syndrome. Evidence of selective expansion of aB cell subset characterized by the expression of cross-reactive idiotypes. Arthritis Rheum 1993; 36: 1128–1136
- Hohler T, Reuss E, Evers N, Dietrich E, Rittner C, Freitag C M, et al. Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: a vaccination study in twins. Lancet 2002; 360: 991–995
- Kraj P, Friedman D F, Stevenson F, Silberstein L E. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol 1995; 154: 6406–6420