Generation of functional dendritic cells (DC) in adult acute lymphoblastic leukemia: rationale for a DC-based vaccination program for patients in complete hematological remission

References

• Banchereau J, Steinman R M. Dendritic cells and the control of immunity. Nature 1998; 19: 245–252
   Web of Science ®Google Scholar
• Rissoan M C, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 19: 1183–1186
   Web of Science ®Google Scholar
• Langenkamp A, Messi M, Lanzavecchia A, Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nature Immunol 2000; 1: 311–316
   PubMed Web of Science ®Google Scholar
• Liu Y J, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nature Immunol 2001; 2: 585–589
   PubMed Web of Science ®Google Scholar
• Yi Q, Desikan R, Barlogie B, Munshi N. Optimizing dendritic cell-based immunotherapy in multiple myeloma. Br J Haematol 2002; 117: 297–305
   PubMed Web of Science ®Google Scholar
• Hsu F J, Benike C, Fagnoni F, Liles T M, Czerwinski D, Taidi B, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med 1996; 2: 52–58
   PubMed Web of Science ®Google Scholar
• Schrappe M, Reiter A, Ludwig W D, Harbott J, Zimmermann M, Hiddemann W, et al. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German – Austrian – Swiss ALL-BFM Study Group. Blood 2000; 95: 3310–3322
   PubMed Web of Science ®Google Scholar
• Copelan E A, McGuire E A. The biology and treatment of acute lymphoblastic leukemia in adults. Blood 1995; 85: 1151–1168
   PubMed Web of Science ®Google Scholar
• Hoelzer D, Gokbuget N, Ottmann O, Pui C H, Relling M V, Appelbaum F R, et al. Acute lymphoblastic leukemia. Hematology 2002; 162–192
   PubMedGoogle Scholar
• Rowe J M, Buck G, Burnett A K, Chopra R, Wiernik P H, Richards S M, et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood 2005; 106: 3760–3767
   PubMed Web of Science ®Google Scholar
• Gökbuget N, Hoelzer D. Recent approaches in acute lymphoblastic leukemia in adults. Rev Clin Exp Hematol 2002; 6: 114–114
   PubMedGoogle Scholar
• Foa R, Vitale A. Towards an integrated classification of adult acute lymphoblastic leukemia. Rev Clin Exp Hematol 2002; 6: 181–199
   PubMedGoogle Scholar
• Bruggemann M, Raff T, Flohr T, Gokbuget N, Nakao M, Droese J, et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood 2006; 10: 1116–1123
   Google Scholar
• Cignetti A, Bryant E, Allione B, Vitale A, Foa R, Cheever M A. CD34(+) acute myeloid and lymphoid leukemic blasts can be induced to differentiate into dendritic cells. Blood 1999; 94: 2048–2055
   PubMed Web of Science ®Google Scholar
• Blair A, Rowbottom A W, Browne S J, Goulden N J, Steward C G, Oakhill A, et al. An optimized biphasic culture system for the generation of functional dendritic cells from patients with acute lymphoblastic leukemia at presentation and in clinical remission. Leukemia 2001; 15: 1596–1603
   PubMed Web of Science ®Google Scholar
• Orsini E, Guarini A, Chiaretti S, Mauro F R, Foa R. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res 2003; 63: 4497–4506
   PubMed Web of Science ®Google Scholar
• Pospisilova D, Borovickova J, Polouckova A, Spisek R, Sediva A, Hrusak O, et al. Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukaemia. Cancer Immunol Immunother 2002; 51: 72–78
   PubMed Web of Science ®Google Scholar
• Houtenbos I, Westers T M, Ossenkoppele G J, van de Loosdrecht A A. Leukemia-derived dendritic cells: towards clinical vaccination protocols in acute myeloid leukemia. Hematologica 2006; 91: 348–355
   PubMed Web of Science ®Google Scholar
• Orsini E, Pasquale A, Maggio R, Calabrese E, Mauro F M, Giammartini E, et al. Phenotypic and functional characterization of monocyte-derived dendritic cells in chronic lymphocytic leukaemia patients: influence of neoplastic CD19+ cells in vivo and in vitro. Br J Haematol 2004; 125: 720–728
   PubMed Web of Science ®Google Scholar
• Haining W N, Cardoso A A, Keczkemethy H L, Fleming M, Neuberg D, DeAngelo D J, et al. Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol 2005; 33: 286–294
   PubMed Web of Science ®Google Scholar
• Albert M L, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998; 392: 86–89
   PubMed Web of Science ®Google Scholar
• de Rijke B, Fredrix H, Zoetbrood A, Scherpen F, Witteveen H, De Witte T, et al. Generation of autologous cytotoxic and helper T-cell responses against the B-cell leukemia-associated antigen HB-1: relevance for precursor B-ALL-specific immunotherapy. Blood 2003; 102: 2885–2891
   PubMed Web of Science ®Google Scholar
• Hagihara M, Tsuchiya T, Hyodo O, Ueda Y, Tazume K, Gansuvd B, et al. The in vitro generation of Ph1+ ALL-specific HLA-A24-restricted cytotoxic T lymphocytes using a synthetic 16 mer minor bcr-abl peptide. Leuk Res 2003; 27: 253–257
   PubMed Web of Science ®Google Scholar
• Hatakeyama N, Tamura Y, Sahara H, Suzuki N, Suzuki K, Hori T, et al. Induction of autologous CD4- and CD8- mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell-loaded dendritic cells. Exp Hematol 2006; 34: 197–207
   PubMed Web of Science ®Google Scholar