63
Views
9
CrossRef citations to date
0
Altmetric
Commentary

Any role for the nucleophosmin (NPM1) gene in myelodysplastic syndromes and acute myeloid leukemia with chromosome 5 abnormalities?

Pages 2093-2095 | Published online: 01 Jul 2009

References

  • Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254–266
  • Falini B, Bolli N, Shan J, Martelli M P, Liso A, Pucciarini A, et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood 2006; 107: 4514–4523
  • Falini B, Nicoletti I, Martelli M F, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood 2007; 109: 874–885
  • Falini B, Martelli M P, Bolli N, Bonasso R, Ghia E, Pallotta M T, et al. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood 2006; 108: 1999–2005
  • Falini B, Bigerna B, Pucciarini A, Tiacci E, Mecucci C, Morris S W, et al. Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): a comparison with NPMc+ AML. Leukemia 2006; 20: 368–371
  • Shiseki M, Kitagawa Y, Wang Y-H, Yoshinaga K, Kondo T, Kuroiwa H, et al. Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities. Leuk Lymphoma 2007; 48: 2141–2144
  • Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia. Blood 2006; 107: 4011–4020
  • Ohyashiki K, Oshimura M, Uchida H, Nomoto S, Sakai N, Tonomura A, et al. Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia, including one case with a complex translocation. Cancer Genet Cytogenet 1985; 14: 247–255
  • Caudill J S, Sternberg A J, Li C Y, Tefferi A, Lasho T L, Steensma D P. C-terminal nucleophosmin mutations are uncommon in chronic myeloid disorders. Br J Haematol 2006; 133: 638–641
  • Oki Y, Jelinek J, Beran M, Verstovsek S, Kantarjian H M, Issa J P. Mutations and promoter methylation status of NPM1 in myeloproliferative disorders. Haematologica 2006; 91: 1147–1148
  • Zhang Y, Zhang M, Yang L, Xiao Z. NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype. Leuk Res 2007; 31: 109–111
  • Pasqualucci L, Liso A, Martelli M P, Bolli N, Pacini R, Tabarrini A, et al. Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: impact on WHO classification. Blood 2006; 108: 4146–4155
  • Kojima K, Omoto E, Hara M, Sasaki K, Katayama Y, Nawa Y, et al. Myelodysplastic syndrome with translocation (8;21): a distinct myelodysplastic syndrome entity or M2-acute myeloid leukemia with extensive myeloid maturation?. Ann Hematol 1998; 76: 279–282
  • Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K, et al. Role of nucleophosmin in embryonic development and tumorigenesis. Nature 2005; 437: 147–153

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.