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Original Article: Clinical

Pediatric precursor T lymphoblastic leukemia and lymphoblastic lymphoma: Differences in the common regions with loss of heterozygosity at chromosome 6q and their prognostic impact

, MD, PhD, , , , , , , , , & show all
Pages 451-461 | Received 20 Sep 2007, Accepted 24 Nov 2007, Published online: 01 Jul 2009

References

  • Takeuchi S, Koike M, Seriu T, Bartram C R, Schrappe M, Reiter A, et al. Frequent loss of heterozygosity on the long arm of chromosome 6: identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia. Cancer Res 1998; 58: 2618–2623
  • Merup M, Moreno T C, Heyman M, Ronnberg K, Grander D, Detlofsson R, et al. 6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas. Blood 1998; 91: 3397–3400
  • Andreasson P, Hoglund M, Bekassy A N, Garwicz S, Heldrup J, Mitelman F, et al. Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias. Eur J Haematol 2000; 65: 40–51
  • Hayashi Y, Raimondi S C, Look A T, Behm F G, Kitchingman G R, Pui C H, et al. Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia. Blood 1990; 76: 1626–1630
  • Heerema N A, Sather H N, Sensel M G, Kraft P, Nachman J B, Steinherz P G, et al. Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group. J Clin Oncol 1998; 16: 1270–1278
  • Schneider N R, Carroll A J, Shuster J J, Pullen D J, Link M P, Borowitz M J, et al. New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases. Blood 2000; 96: 2543–2549
  • Raimondi S C, Behm F G, Roberson P K, Pui C H, Rivera G K, Murphy S B, et al. Cytogenetics of childhood T-cell leukemia. Blood 1988; 72: 1560–1566
  • Mancini M, Vegna M L, Castoldi G L, Mecucci C, Spirito F, Elia L, et al. Partial deletions of long arm of chromosome 6: biologic and clinical implications in adult acute lymphoblastic leukemia. Leukemia 2002; 16: 2055–2061
  • Walters R, Kantarjian H M, Keating M J, Estey E H, Trujillo J, Cork A, et al. The importance of cytogenetic studies in adult acute lymphocytic leukemia. Am J Med 1990; 89: 579–587
  • Foroni L, Sorour A, and Sinclair P, Duke V. Loss of heterozygosity [LOH] and microsatellite instability [MSI] of chromosme 6q16-21 identifies a prognostically poor group of childhood and adult T cell acute lymphoblastic leukemia [ALL] patients. Abstract, Blood 2003; 102: 606
  • Heerema N A, Sather H N, Sensel M G, Lee M K, Hutchinson R, Lange B J, et al. Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group. Leuk Lymphoma 2000; 36: 467–478
  • Takeuchi S, Tsukasaki K, Bartram C R, Seriu T, Zimmermann M, Schrappe M, et al. Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia. Leukemia 2003; 17: 149–154
  • Brunning R D, Borowitz M, Matutes E, Head D, Flandrin G, Swerdlow S H, . Precursor T lymphoblastic leukeamia/lymphoblastic lymphoma. Tumors of Haematopoietic and Lymphoid Tissues, E S Jaffe, N L Harris, H Stein, J Vardiman, et al. IARC Press, Lyon 2001; 115–117
  • Sandlund J, Marcus K, Behm F. Management of lymphoma in children. Non-Hodgkin's Lymphoma, P Mauch, J Armitage, B Coiffier, R Dalla-Favera, N Harris. Lippincott Williams & Wilkins, Philadelphia 2003; 575–597
  • Moricke A, Zimmermann M, Reiter A, Gadner H, Odenwald E, Harbott J, et al. Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95. Klin Padiatr 2005; 217: 310–320
  • Burkhardt B, Zimmermann M, Oschlies I, Niggli F, Mann G, Parwaresch R, et al. The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol 2005; 131: 39–49
  • Reiter A, Schrappe M, Ludwig W D, Tiemann M, Parwaresch R, Zimmermann M, et al. Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report. Blood 2000; 95: 416–421
  • Burkhardt B, Reiter A, Lang P, Lassay L, Dickerhoff R, Lakomek M, et al. Relapse in pediatric pts with T-cell lymphoblastic lymphoma: clinical characteristics and outcome in the BFM group. Abstract. Pediatric Blood Cancer 2006; 46: 842
  • Schrappe M, Reiter A, Zimmermann M, Harbott J, Ludwig W D, Henze G, et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin – Frankfurt – Munster. Leukemia 2000; 14: 2205–2222
  • Raetz E A, Perkins S L, Bhojwani D, Smock K, Philip M, Carroll W L, et al. Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. Pediatr Blood Cancer 2006; 47: 130–140
  • Baleydier F, Asnafi V, Decouvelaere A-V, Gaulard P, Molina T, Delabesse E, et al. T lymphoblastic lymphoma [T-LL]: one or two diseases? Abstract. Blood 2005; 106: 789a
  • Reiter A, Schrappe M, Ludwig W D, Hiddemann W, Sauter S, Henze G, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 1994; 84: 3122–3133
  • Van Dongen J J, Seriu T, Panzer-Grumayer E R, Biondi A, Pongers-Willemse M J, Corral L, et al. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet 1998; 352: 1731–1738
  • Bene M C, Castoldi G, Knapp W, Ludwig W D, Matutes E, Orfao A, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias [EGIL]. Leukemia 1995; 9: 1783–1786
  • Burkhardt B, Woessmann W, Zimmermann M, Kontny U, Vormoor J, Doerffel W, et al. Impact of cranial radiotherapy on central nervous system prophylaxis in children and adolescents with central nervous system-negative stage III or IV lymphoblastic lymphoma. J Clin Oncol 2006; 24: 491–499
  • Li C Y, Chow C, Chan W Y. Allelic imbalance mapped to 6q14.1 is associated with loss of expression of 5-HT receptor 1B in non-Hodgkin lymphomas. Diagn Mol Pathol 2004; 13: 69–74
  • Kaplan E L, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assos 1958; 53: 457–481
  • Mantel E. Evaluation of survival data and tow new rank order statistics arising in its consideration. Cancer Chemother Rep 1966; 50: 163–170
  • Kalbfleisch J D, Prentice R L. The Statistical Analysis of Failure Time Data. Wiley, New York 1980; 163–188
  • Gray R J. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988; 16: 1141–1154
  • Breslow N E, Day N E. Statistical Methods in Cancer Research. IARC, Lyon 2005
  • Burkhardt B, Bruch J, Zimmermann M, Strauch K, Parwaresch R, Ludwig W D, et al. Loss of heterozygosity on chromosome 6q14-q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma. Leukemia 2006; 20: 1422–1429
  • Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2007, [Epub ahead of print Sept]
  • Ohata N, Ito S, Yoshida A, Kunisada T, Numoto K, Jitsumori Y, et al. Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. Int J Mol Med 2006; 18: 1153–1158
  • Sinclair P B, Sorour A, Martineau M, Harrison C J, Mitchell W A, O'Neill E, et al. A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene. Cancer Res 2004; 64: 4089–4098
  • Hatta Y, Yamada Y, Tomonaga M, Miyoshi I, Said J W, Koeffler H P. Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia. Blood 1999; 93: 613–616
  • Zhang Y, Matthiesen P, Harder S, Siebert R, Castoldi G, Calasanz M J, et al. A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization. Genes Chromosomes Cancer 2000; 27: 52–58
  • Gerard B, Cave H, Guidal C, Dastugue N, Vilmer E, Grandchamp B. Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm. Leukemia 1997; 11: 228–232
  • Sherratt T, Morelli C, Boyle J M, Harrison C J. Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21. Chromosome Res 1997; 5: 118–124
  • Mullighan C G, Goorha S, Radtke I, Miller C B, Coustan-Smith E, Dalton J D, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758–764

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