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Molecular genetic characterization reveals new subsets of mantle cell lymphoma

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Pages 1042-1049 | Received 20 Jan 2008, Accepted 22 Jan 2008, Published online: 01 Jul 2009

References

  • Argatoff L H, Connors J M, Klasa R J, Horsman D E, Gascoyne R D. Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 1997; 89: 2067–2078
  • E S Jaffe, Harris, N L, Stein, H, Vardiman, J W. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Haematopoetic and Lymphoid Tissues. Lyon, IARC Press. 2001
  • Howard O M, Gribben J G, Neuberg D S, Grossbard M, Poor C, Janicek M J, et al. Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival. J Clin Oncol 2002; 20: 1288–1294
  • Dreyling M, Lenz G, Hoster E, Van Hoof A, Gisselbrecht C, Schmits R, et al. Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network. Blood 2005; 105: 2677–2684
  • Lenz G, Dreyling M, Hoster E, Wormann B, Duhrsen U, Metzner B, et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol 2005; 23: 1984–1992
  • Witzig T E. Current treatment approaches for mantle-cell lymphoma. J Clin Oncol 2005; 23: 6409–6414
  • Leonard J P, Furman R R, Coleman M. Proteasome inhibition with bortezomib: a new therapeutic strategy for non-Hodgkin's lymphoma. Int J Cancer 2006; 119: 971–979
  • Greiner T C, Moynihan M J, Chan W C, Lytle D M, Pedersen A, Anderson J R, et al. p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 1996; 87: 4302–4310
  • Hernandez L, Fest T, Cazorla M, Teruya-Feldstein J, Bosch F, Peinado M A, et al. p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood 1996; 87: 3351–3359
  • Bea S, Ribas M, Hernandez J M, Bosch F, Pinyol M, Hernandez L, et al. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood 1999; 93: 4365–4374
  • Swerdlow S H, Williams M E. From centrocytic to mantle cell lymphoma: a clinicopathologic and molecular review of 3 decades. Hum Pathol 2002; 33: 7–20
  • Gladden A B, Diehl J A. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem 2005; 96: 906–913
  • Gladden A B, Woolery R, Aggarwal P, Wasik M A, Diehl J A. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene 2006; 25: 998–1007
  • Fu K, Weisenburger D D, Greiner T C, Dave S, Wright G, Rosenwald A, et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005; 106: 4315–4321
  • Salaverria I, Zettl A, Bea S, Moreno V, Valls J, Hartmann E, et al. Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J Clin Oncol 2007; 25: 1216–1222
  • Raty R, Franssila K, Joensuu H, Teerenhovi L, Elonen E. Ki-67 expression level, histological subtype, and the International Prognostic Index as outcome predictors in mantle cell lymphoma. Eur J Haematol 2002; 69: 11–20
  • Rosenwald A, Wright G, Wiestner A, Chan W C, Connors J M, Campo E, et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003; 3: 185–197
  • Flordal Thelander E, Ichimura K, Collins V P, Walsh S H, Barbany G, Hagberg A, et al. Detailed assessment of copy number alterations revealing homozygous deletions in lp and 13q in mantle cell lymphoma. Leuk Res 2007; 31: 1219–1230
  • Fugmann S D, Lee A I, Shockett P E, Villey I J, Schatz D G. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol 2000; 18: 495–527
  • Lewis S M. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 1994; 56: 27–150
  • Papavasiliou F N, Schatz D G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 2002; 109: S35–S44
  • Rada C, Williams G T, Nilsen H, Barnes D E, Lindahl T, Neuberger M S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002; 12: 1748–1755
  • Kuppers R, Klein U, Hansmann M L, Rajewsky K. Cellular origin of human B-cell lymphomas. N Engl J Med 1999; 341: 1520–1529
  • Bird J, Galili N, Link M, Stites D, Sklar J. Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J Exp Med 1988; 168: 229–245
  • Bahler D W, Campbell M J, Hart S, Miller R A, Levy S, Levy R. Ig VH gene expression among human follicular lymphomas. Blood 1991; 78: 1561–1568
  • Kuppers R, Rajewsky K, Hansmann M L. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 1997; 27: 1398–1405
  • Lossos I S, Alizadeh A A, Eisen M B, Chan W C, Brown P O, Botstein D, et al. Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad Sci USA 2000; 97: 10209–10213
  • Rettig M B, Vescio R A, Cao J, Wu C H, Lee J C, Han E, et al. VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4-34) gene. Blood 1996; 87: 2846–2852
  • Damle R N, Wasil T, Fais F, Ghiotto F, Valetto A, Allen S L, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840–1847
  • Hamblin T J, Davis Z, Gardiner A, Oscier D G, Stevenson F K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848–1854
  • Chiorazzi N, Rai K R, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005; 352: 804–815
  • Walsh S H, Rosenquist R. Immunoglobulin gene analysis of mature B-cell malignancies: reconsideration of cellular origin and potential antigen involvement in pathogenesis. Med Oncol 2005; 22: 327–341
  • Camacho F I, Algara P, Rodriguez A, Ruiz-Ballesteros E, Mollejo M, Martinez N, et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood 2003; 101: 4042–4046
  • Kienle D, Krober A, Katzenberger T, Ott G, Leupolt E, Barth T F, et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 2003; 102: 3003–3009
  • Walsh S H, Thorsélius M, Johnson A, Söderberg O, Jerkeman M, Björck E, et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 2003; 101: 4047–4054
  • Lai R, Lefresne S V, Franko B, Hui D, Mirza I, Mansoor A, et al. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome. Mod Pathol 2006; 19: 1498–1505
  • Orchard J, Garand R, Davis Z, Babbage G, Sahota S, Matutes E, et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 2003; 101: 4975–4981
  • Inagaki H, Nakamura T, Li C, Sugiyama T, Asaka M, Kodaira J, et al. Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion. Am J Surg Pathol 2004; 28: 1560–1567
  • Du M Q. MALT Lymphoma: recent advances in aetiology and molecular genetics. J Clin Exp Hematop 2007; 47: 31–42
  • Viswanatha D S, Dogan A. Hepatitis C virus and lymphoma. J Clin Pathol 2007; 60: 1378–1383
  • Johnson T A, Rassenti L Z, Kipps T J. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997; 158: 235–246
  • Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen S L, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515–1525
  • Rosenquist R, Lindström A, Holmberg D, Lindh J, Roos G. V(H) gene family utilization in different B-cell lymphoma subgroups. Eur J Haematol 1999; 62: 123–128
  • Tobin G, Thunberg U, Johnson A, Eriksson I, Söderberg O, Karlsson K, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003; 101: 4952–4957
  • Thorsélius M, Walsh S, Eriksson I, Thunberg U, Johnson A, Backlin C, et al. Somatic hypermutation and V(H) gene usage in mantle cell lymphoma. Eur J Haematol 2002; 68: 217–224
  • Fang Q, Kannapell C C, Gaskin F, Solomon A, Koopman W J, Fu S M. Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of V lambda IIIb. J Exp Med 1994; 179: 1445–156
  • Elagib K E, Tengner P, Levi M, Jonsson R, Thompson K M, Natvig J B, et al. Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjogren's syndrome. Arthritis Rheum 1999; 42: 2471–2481
  • Cappione A J, Pugh-Bernard A E, Anolik J H, Sanz I. Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol 2004; 172: 4298–4307
  • Tobin G, Thunberg U, Johnson A, Thörn I, Söderberg O, Hultdin M, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262–2264
  • Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007; 109: 259–270
  • Hillson J L, Karr N S, Oppliger I R, Mannik M, Sasso E H. The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A. J Exp Med 1993; 178: 331–336
  • Bertoni F, Zucca E, Cotter F E. Molecular basis of mantle cell lymphoma. Br J Haematol 2004; 124: 130–140
  • Bodrug S E, Warner B J, Bath M L, Lindeman G J, Harris A W, Adams J M. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. Embo J 1994; 13: 2124–2130
  • Lovec H, Grzeschiczek A, Kowalski M B, Moroy T. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. Embo J 1994; 13: 3487–3495
  • Kohlhammer H, Schwaenen C, Wessendorf S, Holzmann K, Kestler H A, Kienle D, et al. Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions. Blood 2004; 104: 795–801
  • Rubio-Moscardo F, Climent J, Siebert R, Piris M A, Martin-Subero J I, Nielander I, et al. Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood 2005; 105: 4445–4454
  • Schraders M, Pfundt R, Straatman H M, Janssen I M, van Kessel A G, Schoenmakers E F, et al. Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization. Blood 2005; 105: 1686–1693
  • Tagawa H, Karnan S, Suzuki R, Matsuo K, Zhang X, Ota A, et al. Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 2005; 24: 1348–1358
  • Rinaldi A, Kwee I, Taborelli M, Largo C, Uccella S, Martin V, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol 2006; 132: 303–316
  • Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, et al. Genomic Aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916
  • Aoun P, Blair H E, Smith L M, Dave B J, Lynch J, Weisenburger D D, et al. Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma 2004; 45: 1595–1603
  • Parry-Jones N, Matutes E, Morilla R, Brito-Babapulle V, Wotherspoon A, Swansbury G J, et al. Cytogenetic abnormalities additional to t(11;14) correlate with clinical features in leukaemic presentation of mantle cell lymphoma, and may influence prognosis: a study of 60 cases by FISH. Br J Haematol 2007; 137: 117–124
  • Stilgenbauer S, Schaffner C, Winkler D, Ott G, Leupolt E, Bentz M, et al. The ATM gene in the pathogenesis of mantle-cell lymphoma. Ann Oncol 2000; 11: 127–130
  • Flordal Thelander E, Walsh S H, Thorsélius M, Laurell A, Landgren O, Larsson C, et al. Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes. Mod Pathol 2005; 18: 331–339
  • Mestre-Escorihuela C, Rubio-Moscardo F, Richter J A, Siebert R, Climent J, Fresquet V, et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2006; 109: 271–280

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