218
Views
13
CrossRef citations to date
0
Altmetric
Reviews

Primary mediastinal B-cell lymphoma: Treatment and therapeutic targets

, &
Pages 1050-1061 | Received 29 Sep 2007, Accepted 02 Feb 2008, Published online: 01 Jul 2009

References

  • Haioun C, Gaulard P, Roudot-Thoraval F, Divine M, Jouault H, Lebourgeois J P, et al. Mediastinal diffuse large-cell lymphoma with sclerosis: a condition with a poor prognosis. Am J Clin Oncol 1989; 12: 425–429
  • Lazzarino M, Orlandi E, Paulli M, Boveri E, Morra E, Brusamolino E, et al. Primary mediastinal B-cell lymphoma with sclerosis: an aggressive tumour with distinctive clinical and pathologic features. J Clin Oncol 1993; 11: 2306–2313
  • Todeschini G, Ambrosetti A, Meneghini V, Pizzolo G, Menestrina F, Chilosi M, et al. Mediastinal large-B-cell lymphoma with sclerosis: a clinical study of 21 patients. J Clin Oncol 1990; 8: 804–808
  • Lavabre-Bertrand T, Donadio D, Fegueux N, Jessueld D, Taib J, Charlier D, et al. A study of 15 cases of primary mediastinal lymphoma of B-cell type. Cancer 1992; 69: 2561–2566
  • Savage K J, Monti S, Kutok J L, Cattoretti G, Neuberg D, De Leval L, et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003; 102: 3871–3879
  • Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne R D, et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003; 198: 851–862
  • Rodriguez J, Pugh W C, Romaguera J E, Cabanillas F. Primary mediastinal large cell lymphoma. Hematol Oncol 1994; 12: 175–184
  • Banks P M, Warnke R A. Mediastinal (thymic) large B-cell lymphoma. World Health Organization Classification of Tumours. Pathology and genetics of Tumours of Hematopoietic and Lymphoid Tissues, E S Jaffe, N L Harris, H Stein. IARC Press, Lyon 2001
  • Miller J B, Variakojis D, Bitran J D, Sweet D L, Kinzie J J, Golomb H M, et al. Diffuse histiocytic lymphoma with sclerosis: a clinicopathologic entity frequently causing superior venacaval obstruction. Cancer 1981; 47: 748–756
  • Trump D L, Mann R B. Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement. Cancer 1982; 50: 277–282
  • Levitt L J, Aisenberg A C, Harris N L, Linggood R M, Poppema S. Primary non-Hodgkin's lymphoma of the mediastinum. Cancer 1982; 50: 2486–2492
  • Rodriguez J, Pugh W C, Romaguera J E, Luthra R, Hagemeister F B, McLaughlin P, et al. Primary mediastinal large cell lymphoma is characterized by an inverted pattern of large tumoural mass and low beta 2 microglobulin levels in serum and frequently elevated levels of serum lactate dehydrogenase. Ann Oncol 1994; 5: 847–849
  • Scarpa A, Borgato L, Chilosi M, Capelli P, Menestrina F, Bonetti F, et al. Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age. Blood 1991; 78: 780–788
  • Joos S, Otano-Joos M I, Ziegler S, Bruderlein S, du Manoir S, Bentz M, et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood 1996; 87: 1571–1578
  • Scarpa A, Taruscio D, Scardoni M, Iosi F, Paradisi S, Ennas M G, et al. Nonrandom chromosomal imbalances in primary mediastinal B-cell lymphoma detected by arbitrarily primed PCR fingerprinting. Genes Chromosomes Cancer 1999; 26: 203–209
  • Melzner I, Bucur A J, Bruderlein S, Dorsch K, Hasel C, Barth T F, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood 2005; 105: 2535–2542
  • Mestre C, Rubio-Moscardo F, Rosenwald A, Climent J, Dyer M J, Staudt L, et al. Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarrays. Leukemia 2005; 19: 1082–1084
  • Traverse-Glehen A, Pittaluga S, Gaulard P, Sorbara L, Alonso M A, Raffeld M, et al. Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. Am J Surg Pathol 2005; 29: 1411–1421
  • Garcia J F, Mollejo M, Fraga M, Forteza J, Muniesa J A, Perez-Guillermo M, et al. Large B-cell lymphoma with Hodgkin's features. Histopathology 2005; 47: 101–110
  • Copie-Bergman C, Gaulard P, Maouche-Chretien L, Briere J, Haioun C, Alonso M A, et al. The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood 1999; 94: 3567–3575
  • Hsi E D, Sup S J, Alemany C, Tso E, Skacel M, Elson P, et al. MAL is expressed in a subset of Hodgkin lymphoma and identifies a population of patients with poor prognosis. Am J Clin Pathol 2006; 125: 776–782
  • Freeman G J, Long A J, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192: 1027–1034
  • Latchman Y, Wood C R, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001; 2: 261–268
  • Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, et al. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005; 207: 243–249
  • Alizadeh A A, Eisen M B, Davis R E, Ma C, Lossos I S, Rosenwald A, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511
  • Pileri S A, Gaidano G, Zinzani P L, Falini B, Gaulard P, Zucca E, et al. Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB 1, and PU.1 in the absence of immunoglobulins. Am J Pathol 2003; 162: 243–253
  • Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland M L, Le Gouvello S, Gaulard P, et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood 2004; 104: 543–549
  • Niiro H, Clark E A. Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol 2002; 2: 945–956
  • Banham A H, Beasley N, Campo E, Fernandez P L, Fidler C, Gatter K, et al. The FOXP1 winged helix transcription factor is a novel candidate tumour suppressor gene on chromosome 3p. Cancer Res 2001; 61: 8820–8829
  • Skinnider B F, Elia A J, Gascoyne R D, Trumper L H, von Bonin F, Kapp U, et al. Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 2001; 97: 250–255
  • Ohshima K, Akaiwa M, Umeshita R, Suzumiya J, Izuhara K, Kikuchi M. Interleukin-13 and interleukin-13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis. Histopathology 2001; 38: 368–375
  • Copie-Bergman C, Boulland M L, Dehoulle C, Moller P, Farcet J P, Dyer M J, et al. Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma. Blood 2003; 101: 2756–2761
  • Peh S C, Kim L H, Poppema S. TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma. Am J Surg Pathol 2001; 25: 925–929
  • Schwab U, Stein H, Gerdes J, Lemke H, Kirchner H, Schaadt M, et al. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature 1982; 299: 65–67
  • Feuerhake F, Kutok J L, Monti S, Chen W, LaCasce A S, Cattoretti G, et al. NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood 2005; 106: 1392–1399
  • de Leval L, Ferry J A, Falini B, Shipp M, Harris N L. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells?. Am J Surg Pathol 2001; 25: 1277–1282
  • Weniger M A, Pulford K, Gesk S, Ehrlich S, Banham A H, Lyne L, et al. Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma. Leukemia 2006; 20: 1880–1882
  • Hsu F J, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995; 86: 3072–3082
  • Kuppers R, Klein U, Hansmann M L, Rajewsky K. Cellular origin of human B-cell lymphomas. N Engl J Med 1999; 341: 1520–1529
  • Kuppers R, Rajewsky K, Hansmann M L. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 1997; 27: 1398–1405
  • Malpeli G, Barbi S, Moore P S, Scardoni M, Chilosi M, Scarpa A, et al. Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica 2004; 89: 1091–1099
  • Staudt L M, Dave S. The biology of human lymphoid malignancies revealed by gene expression profiling. Adv Immunol 2005; 87: 163–208
  • Takahashi H, Feuerhake F, Monti S, Kutok J L, Aster J C, Shipp M A. Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma. Blood 2006; 107: 844–845
  • Calvo K R, Traverse-Glehen A, Pittaluga S, Jaffe E S. Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. Adv Anat Pathol 2004; 11: 227–238
  • Zamo A, Malpeli G, Scarpa A, Doglioni C, Chilosi M, Menestrina F. Expression of TP73L is a helpful diagnostic marker of primary mediastinal large B-cell lymphomas. Mod Pathol 2005; 18: 1448–1453
  • Todeschini G, Secchi S, Morra E, Vitolo U, Orlandi E, Pasini F, et al. Primary mediastinal large B-cell lymphoma (PMLBCL): long-term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B. Br J Cancer 2004; 90: 372–376
  • Zinzani P L, Martelli M, Bertini M, Gianni A M, Devizzi L, Federico M, et al. Induction chemotherapy strategies for primary mediastinal large B-cell lymphoma with sclerosis: a retrospective multinational study on 426 previously untreated patients. Haematologica 2002; 87: 1258–1264
  • Savage K J, Al-Rajhi N, Voss N, Paltiel C, Klasa R, Gascoyne R D, et al. Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Ann Oncol 2006; 17: 123–130
  • Hamlin P A, Portlock C S, Straus D J, Noy A, Singer A, Horwitz S M, et al. Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999. Br J Haematol 2005; 130: 691–699
  • Romaguera J E, Rodriguez Diaz-Pavon J, Carias L, Hagemeister F B, McLaughlin P, Rodriguez M A, et al. Use of the international prognostic index and the tumour score to detect poor-risk patients with primary mediastinal large B-cell lymphoma: a study of 37 previously untreated patients. Leuk Lymphoma 1998; 28: 295–306
  • Rodriguez J, Cabanillas F, McLaughlin P, Swan F, Rodriguez M, Hagemeister F, et al. A proposal for a simple staging system for intermediate grade lymphoma and immunoblastic lymphoma based on the ‘tumour score’. Ann Oncol 1992; 3: 711–717
  • Rodriguez J, Conde E, Gutierrez A, Garcia-Ruiz J C, Lahuerta J J, Varela M R, et al. Front-line autologous stem cell transplantation (ASCT) in primary mediastinal large B-cell lymphoma: the GEL-TAMO experience. Blood 2006; 108: 3056
  • Lazzarino M, Orlandi E, Paulli M, Strater J, Klersy C, Gianelli U, et al. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patients. J Clin Oncol 1997; 15: 1646–1653
  • Zinzani P L, Martelli M, Bendandi M, De Renzo A, Zaccaria A, Pavone E, et al. Primary mediastinal large B-cell lymphoma with sclerosis: a clinical study of 89 patients treated with MACOP-B chemotherapy and radiation therapy. Haematologica 2001; 86: 187–191
  • Fisher R I, Gaynor E R, Dahlberg S, Oken M M, Grogan T M, Mize E M, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med 1993; 328: 1002–1006
  • Dunleavy K, Pittaluga S, Janik J, Grant N, Steinberg S, Staudt L, et al. Primary mediastinal large B-cell lymphoma (PMBL) outcome is significantly improved by the addition of rituximab to dose adjusted (DA)-EPOCH and overcomes the need for radiation. Blood 2005; 106: 929
  • Zinzani P L, Martelli M, Magagnoli M, Pescarmona E, Scaramucci L, Palombi F, et al. Treatment and clinical management of primary mediastinal large B-cell lymphoma with sclerosis: MACOP-B regimen and mediastinal radiotherapy monitored by (67)Gallium scan in 50 patients. Blood 1999; 94: 3289–3293
  • Bieri S, Roggero E, Zucca E, Bertoni F, Pianca S, Sanna P, et al. Primary mediastinal large B-cell lymphoma (PMLCL): the need for prospective controlled clinical trials. Leuk Lymphoma 1999; 35: 139–146
  • Kirn D, Mauch P, Shaffer K, Pinkus G, Shipp M A, Kaplan W D, et al. Large-cell and immunoblastic lymphoma of the mediastinum: prognostic features and treatment outcome in 57 patients. J Clin Oncol 1993; 11: 1336–1343
  • Cazals-Hatem D, Lepage E, Brice P, Ferrant A, d'Agay M F, Baumelou E, et al. Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (“Groupe d'Etude des Lymphomes de l'Adulte”) study. Am J Surg Pathol 1996; 20: 877–888
  • Adams M J, Lipsitz S R, Colan S D, Tarbell N J, Treves S T, Diller L, et al. Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy. J Clin Oncol 2004; 22: 3139–3148
  • Sehn L H, Antin J H, Shulman L N, Mauch P, Elias A, Kadin M E, et al. Primary diffuse large B-cell lymphoma of the mediastinum: outcome following high-dose chemotherapy and autologous hematopoietic cell transplantation. Blood 1998; 91: 717–723
  • Vose J M, Bierman P J, Anderson J R, Harrison K A, Dalrymple G V, Byar K, et al. Single-photon emission computed tomography gallium imaging versus computed tomography: predictive value in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1996; 14: 2473–2479
  • Popat U, Przepiork D, Champlin R, Pugh W, Amin K, Mehra R, et al. High-dose chemotherapy for relapsed and refractory diffuse large B-cell lymphoma: mediastinal localization predicts for a favorable outcome. J Clin Oncol 1998; 16: 63–69
  • Nademanee A, Molina A, O'Donnell M R, Dagis A, Snyder D S, Parker P, et al. Results of high-dose therapy and autologous bone marrow/stem cell transplantation during remission in poor-risk intermediate- and high-grade lymphoma: international index high and high-intermediate risk group. Blood 1997; 90: 3844–3852
  • Rodriguez J, Caballero M D, Gutierrez A, Solano C, Arranz R, Lahuerta J J, et al. Autologous stem-cell transplantation in diffuse large B-cell non-Hodgkin's lymphoma not achieving complete response after induction chemotherapy: the GEL/TAMO experience. Ann Oncol 2004; 15: 1504–1509
  • Rodriguez J. Should rituximab be used prior to autologous stem-cell transplantation for non-Hodgkin's lymphoma?. Nat Clin Pract Oncol 2005; 2: 74–75
  • Moskowitz C, Hamlin P A, Horwitz S M, Noy A, O'Connor O A, Palomba M, et al. Phase II trial of dose-dense R-CHOP followed by risk-adapted consolidation with either ICE or ICE and ASCT, based upon the results of biopsy confirmed abnormal interim restaging PET scan, improves outcome in patients with advanced stage DLBCL. Blood 2006; 108: 532
  • Dupuis J, Gaulard P, Hemery F, Itti E, Gisselbrecht C, Rahmouni A, et al. Respective prognostic values of germinal center phenotype and early (18)fluorodeoxyglucose-positron emission tomography scanning in previously untreated patients with diffuse large B-cell lymphoma. Haematologica 2007; 92: 778–783
  • Haioun C, Itti E, Rahmouni A, Brice P, Rain J D, Belhadj K, et al. [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in aggressive lymphoma: an early prognostic tool for predicting patient outcome. Blood 2005; 106: 1376–1381
  • Sanchez-Beato M, Sanchez-Aguilera A, Piris M A. Cell cycle deregulation in B-cell lymphomas. Blood 2003; 101: 1220–1235
  • Jacobson J O, Aisenberg A C, Lamarre L, Willett C G, Linggood R M, Miketic L M, et al. Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy. Cancer 1988; 62: 1893–1898
  • Bertini M, Orsucci L, Vitolo U, Levis A, Todeschini G, Meneghini V, et al. Stage II large B-cell lymphoma with sclerosis treated with MACOP-B. Ann Oncol 1991; 2: 733–737
  • Falini B, Venturi S, Martelli M, Santucci A, Pileri S, Pescarmona E, et al. Mediastinal large B-cell lymphoma: clinical and immunohistological findings in 18 patients treated with different third-generation regimens. Br J Haematol 1995; 89: 780–789
  • Zinzani P L, Bendandi M, Frezza G, Gherlinzoni F, Merla E, Salvucci M, et al. Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patients. Leuk Lymphoma 1996; 21: 311–316
  • Martelli M P, Martelli M, Pescarmona E, De Sanctis V, Donato V, Palombi F, et al. MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosis. Ann Oncol 1998; 9: 1027–1029
  • Abou-Elella A A, Weisenburger D D, Vose J M, Kollath J P, Lynch J C, Bast M A, et al. Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group. J Clin Oncol 1999; 17: 784–790
  • Cairoli R, Grillo G, Tedeschi A, Gargantini L, Marenco P, Tresoldi E, et al. Efficacy of an early intensification treatment integrating chemotherapy, autologous stem cell transplantation and radiotherapy for poor risk primary mediastinal large B cell lymphoma with sclerosis. Bone Marrow Transplant 2002; 29: 473–477

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.