Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels

References

• Rebollo A, Schmitt C, Ikaros Aiolos. Helios: transcription regulators and lymphoid malignancies. Immunol Cell Biol 2003; 81: 171–175
   PubMed Web of Science ®Google Scholar
• Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2002; 2: 162–174
   PubMed Web of Science ®Google Scholar
• Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995; 83: 289–299
   PubMed Web of Science ®Google Scholar
• Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol 1997; 15: 155–176
   PubMed Web of Science ®Google Scholar
• Wang J H, Nichogiannopoulou A, Wu L, Sun L, Sharpe A H, Bigby M, et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996; 5: 537–549
   PubMed Web of Science ®Google Scholar
• Sun L, Crotty M L, Sensel M, Sather H, Navara C, Nachman J, et al. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin Cancer Res 1999; 5: 2112–2120
   PubMed Web of Science ®Google Scholar
• Sun L, Goodman P A, Wood C M, Crotty M L, Sensel M, Sather H, et al. Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia. J Clin Oncol 1999; 17: 3753–3766
   PubMed Web of Science ®Google Scholar
• Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A, et al. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1999; 96: 680–685
   PubMed Web of Science ®Google Scholar
• Takanashi M, Yagi T, Imamura T, Tabata Y, Morimoto A, Hibi S, et al. Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia. Br J Haematol 2002; 117: 525–530
   PubMed Web of Science ®Google Scholar
• Ruiz A, Jiang J, Kempski H, Brady H J. Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival. Br J Haematol 2004; 125: 31–37
   PubMed Web of Science ®Google Scholar
• Nakayama H, Ishimaru F, Avitahl N, Sezaki N, Fujii N, Nakase K, et al. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res 1999; 59: 3931–3934
   PubMed Web of Science ®Google Scholar
• Nakase K, Ishimaru F, Avitahl N, Dansako H, Matsuo K, Fujii K, et al. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia. Cancer Res 2000; 60: 4062–4065
   PubMed Web of Science ®Google Scholar
• Olivero S, Maroc C, Beillard E, Gabert J, Nietfeld W, Chabannon C, et al. Detection of different Ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction. Br J Haematol 2000; 110: 826–830
   PubMed Web of Science ®Google Scholar
• Nishii K, Katayama N, Miwa H, Shikami M, Usui E, Masuya M, et al. Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia. Leukemia 2002; 16: 1285–1292
   PubMed Web of Science ®Google Scholar
• Tonnelle C, Imbert M C, Sainty D, Granjeaud S, N'Guyen C, Chabannon C. Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen. Hematol J 2003; 4: 104–109
   PubMedGoogle Scholar
• Beverly L J, Capobianco A J. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell 2003; 3: 551–564
   PubMed Web of Science ®Google Scholar
• Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T, et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 2002; 99: 1350–1355
   PubMed Web of Science ®Google Scholar
• Paling N R, Welham M J. Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. Biochem J 2002; 368: 885–894
   PubMedGoogle Scholar
• Wheadon H, Edmead C, Welham M J. Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2. Biochem J 2003; 376: 147–157
   PubMed Web of Science ®Google Scholar
• Starr R, Willson T A, Viney E M, Murray L J, Rayner J R, Jenkins B J, et al. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387: 917–921
   PubMed Web of Science ®Google Scholar
• Greenhalgh C J, Hilton D J. Negative regulation of cytokine signaling. J Leukoc Biol 2001; 70: 348–356
   PubMed Web of Science ®Google Scholar
• Findley H W, Gu L, Yeager A M, Zhou M. Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 1997; 89: 2986–2993
   PubMed Web of Science ®Google Scholar
• Addeo R, Caraglia M, Baldi A, D'Angelo V, Casale F, Crisci S, et al. Prognostic role of bcl-xL and p53 in childhood acute lymphoblastic leukemia (ALL. Cancer Biol Ther 2005; 4: 32–38
   PubMed Web of Science ®Google Scholar
• Klein F, Feldhahn N, Herzog S, Sprangers M, Mooster J L, Jumaa H, et al. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 2006; 25: 1118–1124
   PubMed Web of Science ®Google Scholar
• Sattler M, Salgia R. Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL. Cytokine Growth Factor Rev 1997; 8: 63–79
   PubMedGoogle Scholar
• Hoover R R, Gerlach M J, Koh E Y, Daley G Q. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene 2001; 20: 5826–5835
   PubMedGoogle Scholar
• Wojcik H, Griffiths E, Staggs S, Hagman J, Winandy S. Expression of a non-DNA- binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis. Eur J Immunol 2007; 37: 1022–1032
   PubMed Web of Science ®Google Scholar
• Ezzat S, Yu S, Asa S LL. Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5’ fibroblast growth factor receptor-4 promoter. Am J Pathol 2003; 163: 1177–1184
   PubMed Web of Science ®Google Scholar
• Grad J M, Zeng X R, Boise L H. Regulation of Bcl-xL: a little bit of this and a little bit of STAT. Curr Opin Oncol 2000; 12: 543–549
   PubMed Web of Science ®Google Scholar
• Darnell J E. STATs and gene regulation. Science 1997; 277: 1630–1635
   PubMed Web of Science ®Google Scholar
• Catlett-Falcone R, Dalton W S, Jove R. STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol 1999; 11: 490–496
   PubMedGoogle Scholar
• Welte T, Leitenberg D, Dittel B N, al-Ramadi B K, Xie B, Chin Y E, et al. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 1999; 283: 222–225
   PubMed Web of Science ®Google Scholar
• Tang X, Downes C P, Whetton A D, Owen-Lynch P J. Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase. J Biol Chem 2000; 275: 13142–13148
   PubMed Web of Science ®Google Scholar
• Maurer U, Charvet C, Wagman A, Dejardin E, Green D. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006; 21: 749–760
   PubMed Web of Science ®Google Scholar
• Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 2001; 409: 349–354
   PubMed Web of Science ®Google Scholar
• Fleming H E, Milne C D, Paige C J. CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro. J Immunol 2004; 173: 2542–2551
   PubMed Web of Science ®Google Scholar
• Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J Exp Med 1999; 190: 1201–1214
   PubMed Web of Science ®Google Scholar
• Papathanasiou P, Perkins A C, Cobb B S, Ferrini R, Sridharan R, Hoyne G F, et al. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 2003; 19: 131–144
   PubMed Web of Science ®Google Scholar
• Brown K E, Guest S S, Smale S T, Hahm K, Merkenschlager M, Fisher A G. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 1997; 91: 845–854
   PubMed Web of Science ®Google Scholar
• Grogan J L, Mohrs M, Harmon B, Lacy D A, Sedat J W, Locksley R M. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 2001; 14: 205–215
   PubMed Web of Science ®Google Scholar
• Christopherson I, Piechoki M, Liu G, Ratner S, Galy A. Regulation of L-selectin expression by a dominant negative Ikaros protein. J Leukoc Biol 2001; 69: 675–683
   PubMed Web of Science ®Google Scholar
• Hafez F M, Hassab H, Morad Z, Farag E A. CD54 and CD62L expression by lymphoid cells in acute lymphoblastic leukaemia in children. Br J Biomed Sci 2003; 60: 149–154
   PubMed Web of Science ®Google Scholar