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Leukemia & Lymphoma Volume 49, 2008 - Issue 6
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Letter to the Editor

Overexpression of the p85α regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells

Elion Hoxha Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Medical Center Hamburg-Eppendorf, Germany
,
Boris Fehse Bone Marrow Transplantation Center, University Medical Center Hamburg-Eppendorf, Germany
,
Gerhard Ortmeyer Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Germany
,
Carol Stocking Heinrich-Pette-Institute for Experimental Virology and Immunology, Hamburg, Germany
,
Georg W. Mayr Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Medical Center Hamburg-Eppendorf, Germany
&
Manfred Jücker Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, University Medical Center Hamburg-Eppendorf, GermanyCorrespondence[email protected]
Pages 1206-1208 | Received 04 Feb 2008, Accepted 14 Feb 2008, Published online: 01 Jul 2009

References

  • Cantley L C. The Phosphoinositide 3-Kinase Pathway. Science 2002; 296: 1655–1657
  • Lee J Y, Engelman J A, Cantley L C. PI3K Charges Ahead. Science 2007; 317: 206–207
  • Min Y H, Eom J I, Cheong J W, Maeng H O, Kim J Y, Jeung H K, et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 2003; 17: 995–997
  • Deane J A, Fruman D A. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol 2004; 22: 563–598
  • Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn C R. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85α regulatory subunit. Mol Cell Biol 2000; 20: 8035–8046
  • Young D C, Griffin J D. Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood 1986; 68: 1178–1181
  • Gu H, Maeda H, Moon J J, Lord J D, Yoakim M, Nelson B H, et al. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol 2000; 20: 7109–7120
  • Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, et al. Increased insulin sensitivity and hypoglycemia in mice lacking the p85α subunit of phosphoinositide 3-kinase. Nat Genet 1999; 21: 230–235

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