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Letters to the Editor

Tumor suppressor WTX gene mutation is rare in acute leukemias

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Pages 1616-1617 | Received 18 Mar 2008, Accepted 04 Apr 2008, Published online: 01 Jul 2009

References

  • Rivera M N, Kim W J, Wells J, Driscoll D R, Brannigan B W, Han M. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science 2007; 315: 642–645
  • Major M B, Camp N D, Berndt J D, Yi X, Goldenberg S J, Hubbert C, et al. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 2007; 316: 1043–1046
  • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469–480
  • Mikesch J H, Steffen B, Berdel W E, Serve H, Müller-Tidow C. The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. Leukemia 2007; 21: 1638–1647
  • Lee J W, Soung Y H, Kim S Y, Lee H W, Park W S, Nam S W, et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005; 24: 1477–1480

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