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Original Articles: Research

Internalisation of uncross-linked rituximab is not essential for the induction of caspase-independent killing in Burkitt lymphoma cell lines

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Pages 1578-1591 | Received 04 Jan 2008, Accepted 25 Apr 2008, Published online: 01 Jul 2009

References

  • Maloney D G, Grillo-Lopez A J, White C A, Bodkin D, Schilder R J, Neidhart J A, et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 2007; 90: 2188–2195
  • Kirchner E M, Ebsen M, Kirchner J, Theegarten D, Voigtmann R. Transformation of Hodgkin's disease to high-grade B-cell lymphoma: remission after rituximab monotherapy. Ann Oncol 2001; 12: 1169–1171
  • Sacchi S, Federico M, Dastoli G, Fiorani C, Vinci G, Clo V, et al. Treatment of B-cell non-Hodgkin's lymphoma with anti CD20 monoclonal antibody rituximab. Crit Rev Oncol Hematol 2001; 37: 13–25
  • Flieger D, Renoth S, Beier I, Sauerbruch T, Schmidt-Wolf I. Mechanism of cytotoxicity induced by chimeric mouse human monoclonal antibody IDEC-C2B8 in CD20-expressing lymphoma cell lines. Cell Immunol 2000; 204: 55–63
  • Golay J, Zaffaroni L, Vaccari T, Lazzari M, Borleri G M, Bernasconi S, et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood 2000; 95: 3900–3908
  • Cragg M S, Glennie M J. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood 2004; 103: 2738–2743
  • Shan D, Ledbetter J A, Press O W. Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol Immunother 2000; 48: 673–683
  • Hofmeister J K, Cooney D, Coggeshall K M. Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis. Blood Cells Mol Dis 2000; 26: 133–143
  • Zhang N, Khawli L A, Hu P, Epstein A L. Generation of rituximab polymer may cause hyper-cross-linking-induced apoptosis in non-Hodgkin's lymphomas. Clin Cancer Res 2005; 11: 5971–5980
  • Bellosillo B, Villamor N, Lopez-Guillermo A, Marce S, Esteve J, Campo E, et al. Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species. Blood 2001; 98: 2771–2777
  • van der Kolk L E, Evers L M, Omene C, Lens S M, Lederman S, van Lier R A, et al. CD20-induced B cell death can bypass mitochondria and caspase activation. Leukemia 2002; 16: 1735–1744
  • Chan H T, Hughes D, French R R, Tutt A L, Walshe C A, Teeling J L, et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X–100 insoluble membrane rafts. Cancer Res 2003; 63: 5480–5489
  • Daniels I, Abulayha A M, Thomson B J, Haynes A P. Caspase-independent killing of Burkitt lymphoma cell lines by rituximab. Apoptosis 2006; 6: 1013–1023
  • Algeciras-Schimnich A, Peter M E. Actin dependent CD95 internalization is specific for Type I cells. FEBS Lett 2003; 546: 185–188
  • Lee K H, Feig C, Tchikov V, Schickel R, Hallas C, Schutze S, et al. The role of receptor internalization in CD95 signaling. Embo J 2006; 25: 1009–1023
  • Sapra P, Allen T M. Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. Cancer Res 2002; 62: 7190–7194
  • Anolik J, Looney R J, Bottaro A, Sanz I, Young F. Down-regulation of CD20 on B cells upon CD40 activation. Eur J Immunol 2003; 33: 2398–2409
  • Sieber T, Schoeler D, Ringel F, Pascu M, Schriever F. Selective internalization of monoclonal antibodies by B-cell chronic lymphocytic leukaemia cells. Br J Haematol 2003; 121: 458–461
  • Jilani I, O'Brien S, Manshuri T, Thomas D A, Thomazy V A, Imam M, et al. Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia. Blood 2003; 102: 3514–3520
  • Michel R B, Mattes M J. Intracellular accumulation of the anti-CD20 antibody 1F5 in B-lymphoma cells. Clin Cancer Res 2002; 8: 2701–2713
  • Michel R B, Mattes M J. Antibodies to CD20 and MHC class II antigen bound to B-lymphoma cells accumulate in shed cytoplasmic fragments. Br J Cancer 2004; 91: 1500–1507
  • Ong G L, Mattes M J. Limitations in the use of low pH extraction to distinguish internalized from cell surface-bound radiolabeled antibody. Nucl Med Biol 2000; 27: 571–575
  • Munoz-Pinedo C, Green D R, van den Berg A. Confocal restricted-height imaging of suspension cells (CRISC) in a PDMS microdevice during apoptosis. Lab Chip 2005; 5: 628–633
  • Schafer D A. Coupling actin dynamics and membrane dynamics during endocytosis. Curr Opin Cell Biol 2002; 14: 76–81
  • Ayscough K R. Coupling actin dynamics to the endocytic process in Saccharomyces cerevisiae. Protoplasma 2005; 226: 81–88
  • Kaksonen M, Toret C P, Drubin D G. Harnessing actin dynamics for clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 2006; 7: 404–414
  • Lamaze C, Fujimoto L M, Yin H L, Schmid S L. The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. J Biol Chem 2007; 272: 20332–20335
  • Kenis H, van Genderen, Deckers N M, Lux P AG, Hofstra L, Narula J, et al. Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches. Exp Cell Res 2006; 312: 719–726
  • Mateo V, Brown E J, Biron G, Rubio M, Fischer A, Deist F L, et al. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 2002; 100: 2882–2890
  • Li J, Li Q, Xie C, Zhou H, Wang Y, Zhang N, et al. β-Actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death. J Cell Sci 2004; 117: 4673–4680
  • Gourlay C W, Ayscough K R. The actin cytoskeleton: a key regulator of apoptosis and ageing?. Nat Rev Mol Cell Biol 2005; 6: 583–589
  • Nusco G A, Chun J T, Ercolano E, Lim D, Gragnaniello G, Kyozuka K, et al. Modulation of calcium signalling by the actin-binding protein cofilin. Biochem Biophys Res Commun 2006; 348: 109–114
  • Söderström T S, Nyberg S D, Eriksson J E. CD95 capping is ROCK-dependent and dispensable for apoptosis. J Cell Sci 2005; 118(Part 10)2211–2223
  • Chichili G R, Rodgers W. Clustering of membrane lipid raft proteins by the actin cytoskeleton. J Biol Chem 2007; 282: 36682–36691
  • Unruh T L, Haidong L, Mutch C M, Shariat N, Grigoriou L, Sanyal R, et al. Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. Immunology 2005; 116: 223–232

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