Beyond the lymphocyte predominant cell: CD4⁺CD8⁺ T-cells in nodular lymphocyte predominant Hodgkin lymphoma

References

• Stein H. Hodgkin lymphomas: introduction. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. 3rd ed, E S Jaffe, N L Harris, H Stein, J W Vardiman. IARC Press, LyonFrance 2001; 239
   Google Scholar
• Stein H, Delsol G, Pileri S, Said J, Mann R, Poppema S, . Nodular lymphocyte predominant Hodgkin lymphoma. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. 3rd ed, E S Jaffe, N L Harris, H Stein, J W Vardiman, et al. IARC Press, LyonFrance 2001; 240–243
   Google Scholar
• Poppema S, Delsol G, Pileri S A, Stein H, Swerdlow S H, Warnke R A, et al. Nodular lymphocyte predominant Hodgkin lymphoma. In: Swerdlow SH, et al., editors. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. IARC Press, LyonFrance 2008; 323–325
   Google Scholar
• Nguyen P L, Ferry J A, Harris N L. Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin's disease: a comparative immunohistochemical study. Am J Surg Pathol 1999; 23: 27–33
   PubMed Web of Science ®Google Scholar
• Bowen M B, Butch A W, Parvin C A, Levine A, Nahm M H. Germinal center T cells are distinct helper-inducer T cells. Hum Immunol 1991; 31: 67–75
   PubMed Web of Science ®Google Scholar
• Timens W, Visser L, Poppema S. Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. Lab Invest 1986; 54: 457–461
   PubMed Web of Science ®Google Scholar
• Caraway N P. Strategies to diagnose lymphoproliferative disorders by fine-needle aspiration by using ancillary studies. Cancer 2005; 105: 432–442
   PubMed Web of Science ®Google Scholar
• Dong H Y, Harris N L, Preffer F I, Pitman M B. Fine-needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: a retrospective analysis of the utility of cytomorphology and flow cytometry. Mod Pathol 2001; 14: 472–481
   PubMed Web of Science ®Google Scholar
• Fromm J R, Kussick S J, Wood B L. Identification and purification of classical Hodgkin cells from lymph nodes by flow cytometry and flow cytometric cell sorting. Am J Clin Pathol 2006; 126: 764–780
   PubMed Web of Science ®Google Scholar
• Gorczyca W, Weisberger J, Liu Z, Tsang P, Hossein M, Wu C D, et al. An approach to diagnosis of T-cell lymphoproliferative disorders by flow cytometry. Cytometry 2002; 50: 177–190
   PubMedGoogle Scholar
• Zeng G, Ewton A, Zu Y, An C, Nishino H, Ponce de Lion A, et al. Quantitative analysis of CD4/CD8 ratios by flow cytometry as an adjunct in diagnosis of Hodgkin's lymphomas [abstract]. Mod Pathol 2005; 18(Suppl 1)259A–260A
   Google Scholar
• Bosler D S, Douglas-Nikitin V K, Harris V N, Smith M D. Detection of T-regulatory cells has a potential role in the diagnosis of classical Hodgkin lymphoma. Cytometry B Clin Cytom 2008; 74: 227–235
   PubMed Web of Science ®Google Scholar
• Hudnall S D, Betancourt E, Barnhart E, Patel J. Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia. Cytometry B Clin Cytom 2008; 74: 1–8
   PubMed Web of Science ®Google Scholar
• Hernandez O, Oweity T, Ibrahim S. Is an increase in CD4/CD8 T-cell ratio in lymph node fine needle aspiration helpful for diagnosing Hodgkin lymphoma? A study of 85 lymph node FNAs with increased CD4/CD8 ratio. Cytojournal 2005; 2: 14
   PubMedGoogle Scholar
• Deaglio S, Dwyer K M, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257–1265
   PubMed Web of Science ®Google Scholar
• Liu W, Putnam A L, Xu-Yu Z, Szot G L, Lee M R, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701–1711
   PubMed Web of Science ®Google Scholar
• Alvaro T, Lejeune M, Salvado M T, Bosch R, Garcia J F, Jaen J, et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 2005; 11: 1467–1473
   PubMed Web of Science ®Google Scholar
• Oh Y H, Weng A, Connors J. Gascoyne RD. CD4/CD8-double positive T cells in nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) [abstract]. Haematologica 2007; 92(Suppl 5)3
   Google Scholar
• Rahemtullah A, Reichard K K, Preffer F I, Harris N L, Hasserjian R P. A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphoma. Am J Clin Pathol 2006; 126: 805–814
   PubMed Web of Science ®Google Scholar
• Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke R A. Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 2003; 27: 1346–1356
   PubMed Web of Science ®Google Scholar
• Rahemtullah A, Jaffe E S, Harris N L, Hasserjian R P. Nodular lymphocyte predominant Hodgkin lymphoma with an interfollicular growth pattern and atypical T cells: A distinct disease variant? [abstract]. Mod Pathol 2008; 21(Suppl 1)270A
   Google Scholar
• Rahemtullah A, Reichard K K, Dorn M E, Preffer F I, Harris N L, Hasserjian R P. Double-positive CD4+CD8+ T-cell populations in nodular lymphocyte predominant Hodgkin lymphoma: further characterization and relationship to other entities [abstract]. Haematologica 2007; 92(Suppl 5)2–3
   PubMed Web of Science ®Google Scholar
• Das D K, Gupta S K. Fine needle aspiration cytodiagnosis of Hodgkin's disease and its subtypes. II. Subtyping by differential cell counts. Acta Cytol 1990; 34: 337–341
   PubMed Web of Science ®Google Scholar
• Davis B H, Foucar K, Szczarkowski W, Ball E, Witzig T, Foon K A, et al. U.S.-Canadian Consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: medical indications. Cytometry 1997; 30: 249–263
   PubMedGoogle Scholar
• Ellis D W, Eaton M, Fox R M, Juneja S, Leong A S, Miliauskas J, et al. Diagnostic pathology of lymphoproliferative disorders. Pathology 2005; 37: 434–456
   PubMed Web of Science ®Google Scholar
• Jorgensen J L. State of the Art Symposium: flow cytometry in the diagnosis of lymphoproliferative disorders by fine-needle aspiration. Cancer 2005; 105: 443–451
   PubMed Web of Science ®Google Scholar
• Katz R L. Modern approach to lymphoma diagnosis by fine-needle aspiration: restoring respect to a valuable procedure. Cancer 2005; 105: 429–431
   PubMed Web of Science ®Google Scholar
• Siebert J D, Weeks L M, List L W, Kugler J W, Knost J A, Fishkin P A, et al. Utility of flow cytometry immunophenotyping for the diagnosis and classification of lymphoma in community hospital clinical needle aspiration/biopsies. Arch Pathol Lab Med 2000; 124: 1792–1799
   PubMed Web of Science ®Google Scholar
• Hansmann M L, Fellbaum C, Hui P K, Moubayed P. Progressive transformation of germinal centers with and without association to Hodgkin's disease. Am J Clin Pathol 1990; 93: 219–226
   PubMed Web of Science ®Google Scholar
• Hicks J, Flaitz C. Progressive transformation of germinal centers: review of histopathologic and clinical features. Int J Pediatr Otorhinolaryngol 2002; 65: 195–202
   PubMed Web of Science ®Google Scholar
• Osborne B M, Butler J J. Clinical implications of progressive transformation of germinal centers. Am J Surg Pathol 1984; 8: 725–733
   PubMed Web of Science ®Google Scholar
• Osborne B M, Butler J J, Gresik M V. Progressive transformation of germinal centers: comparison of 23 pediatric patients to the adult population. Mod Pathol 1992; 5: 135–140
   PubMed Web of Science ®Google Scholar
• Atayar C, Poppema S, Visser L, van den Berg A. Cytokine gene expression profile distinguishes CD4+/CD57+ T cells of the nodular lymphocyte predominance type of Hodgkin's lymphoma from their tonsillar counterparts. J Pathol 2006; 208: 423–430
   PubMed Web of Science ®Google Scholar
• Enblad G, Molin D, Glimelius I, Fischer M, Nilsson G. The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma. Hematol Oncol Clin North Am 2007; 21: 805–823
   PubMed Web of Science ®Google Scholar
• Poppema S, Potters M, Emmens R, Visser L, van den Berg A. Immune reactions in classical Hodgkin's lymphoma. Semin Hematol 1999; 36: 253–259
   PubMed Web of Science ®Google Scholar
• Gandhi M K, Lambley E, Duraiswamy J, Dua U, Smith C, Elliott S, et al. Expression of LAG–3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood 2006; 108: 2280–2289
   PubMed Web of Science ®Google Scholar
• Ishida T, Ishii T, Inagaki A, Yano H, Komatsu H, Iida S, et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006; 66: 5716–5722
   PubMed Web of Science ®Google Scholar
• Das G, Augustine M M, Das J, Bottomly K, Ray P, Ray A. An important regulatory role for CD4+CD8 alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci USA 2003; 100: 5324–5329
   PubMed Web of Science ®Google Scholar
• Ghia P, Prato G, Stella S, Scielzo C, Geuna M, Caligaris-Cappio F. Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly. Br J Haematol 2007; 139: 780–790
   PubMed Web of Science ®Google Scholar
• Helgeland L, Johansen F E, Utgaard J O, Vaage J T, Brandtzaeg P. Oligoclonality of rat intestinal intraepithelial T lymphocytes: overlapping TCR beta-chain repertoires in the CD4 single-positive and CD4/CD8 double-positive subsets. J Immunol 1999; 162: 2683–2692
   PubMed Web of Science ®Google Scholar
• Herndler-Brandstetter D, Schwanninger A, Grubeck-Loebenstein B. CD4+ CD8+ T cells in young and elderly humans. Comment on Macchia I, Gauduin MC, Kaur A, Johnson RP. Expression of CD8alpha identifies a distinct subset of effector memory CD4 T lymphocytes. Immunology 2006; 119: 232–242, Immunology 2007;120:292–294
   PubMed Web of Science ®Google Scholar
• Lee W W, Nam K H, Terao K, Akari H, Yoshikawa Y. Age-related increase of peripheral CD4+ CD8+ double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution. Immunology 2003; 109: 217–225
   PubMed Web of Science ®Google Scholar
• Macchia I, Gauduin M C, Kaur A, Johnson R P. Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes. Immunology 2006; 119: 232–242
   PubMed Web of Science ®Google Scholar
• Nam K, Akari H, Terao K, Shibata H, Kawamura S, Yoshikawa Y. Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(−) T cells in cynomolgus monkeys. Int Immunol 2000; 12: 1095–1103
   PubMed Web of Science ®Google Scholar
• Nascimbeni M, Shin E C, Chiriboga L, Kleiner D E, Rehermann B. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood 2004; 104: 478–486
   PubMed Web of Science ®Google Scholar
• Pahar B, Lackner A A, Veazey R S. Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol 2006; 36: 583–592
   PubMed Web of Science ®Google Scholar
• Watanabe N, De Rosa S C, Cmelak A, Hoppe R, Herzenberg L A, Roederer M. Long-term depletion of naive T cells in patients treated for Hodgkin's disease. Blood 1997; 90: 3662–3672
   PubMed Web of Science ®Google Scholar
• Zuckermann F A, Husmann R J. Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells. Immunology 1996; 87: 500–512
   PubMed Web of Science ®Google Scholar
• Brenchley J M, Karandikar N J, Betts M R, Ambrozak D R, Hill B J, Crotty L E, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101: 2711–2720
   PubMed Web of Science ®Google Scholar