2,682
Views
212
CrossRef citations to date
0
Altmetric
Reviews

Preclinical versus clinical drug combination studies

Pages 2059-2080 | Received 22 Feb 2008, Accepted 15 Jul 2008, Published online: 01 Jul 2009

References

  • Chou T C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006; 68: 621–681, Available at: http://pharmrev.aspetjournals.org/cgi/content/abstract/58/3/621)
  • Chou T C. What is synergy?. Scientist 2007; 21: 15
  • Goldin A, Mantel N. The employment of combinations of drugs in the chemotherapy of neoplasia: a review. Cancer Res 1957; 17: 635–654
  • Greco W R, Bravo G, Parsons J C. The search for synergy: a critical review from response surface perspective. Pharmacol Rev 1995; 47: 331–385
  • Chou T C, Talalay P. A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. J Biol Chem 1977; 252: 6438–6442
  • Chou T C, Talalay P. Generalized equations for the analysis of inhibitions of Michaelis–Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. Eur J Biochem 1981; 115: 207–216
  • Chou T C, Talalay P. Quantitative analysis of dose–effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27–55
  • Chou T C. Combinatorial analysis of multiple substrate-multiple product enzyme reactions. J Theor Biol 1972; 35: 285–297
  • Chou T C. Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition. Mol Pharmacol 1974; 10: 235–247
  • Chou T C. Derivation and properties of Michaelis–Menten type and Hill type equations for reference ligands. J Theor Biol 1976; 59: 253–276
  • Chou T C, Talalay P. Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol Sci 1983; 4: 450–454
  • Chou T C. The median-effect principle and the combination index for quantitation of synergism and antagonism. Synergism and Antagonism in Chemotherapy, T C Chou, D C Rideout. Academic Press, San Diego 1991; 61–102
  • Chou J H, Chou T C. Dose–Effect Analysis with Microcomputers: Quantitation of ED50, ID50, Synergism, Antagonism, Low-Dose Risk, Receptor Ligand Binding and Enzyme Kinetics: Computer Software for the IBM PC Series. Elsevier-Biosoft, CambridgeUK 1989
  • Chou T C, Hayball M P. CalcuSyn for Windows: Multiple-Drug Dose–Effect Analyzer and Manual. Biosoft, CambridgeUK 1997
  • Chou T C, Martin N. CompuSyn for Drug Combinations: PC Software and User's Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values. ComboSyn, Paramus, NJ 2005, Available at: www.combosyn.com
  • Chou T C, Chou J H. The median-effect equation: a unified form for Michaelis–Menten, Hill, Scatchard and Henderson–Hasselbalch equations. FASEB J 1990; 6: 824
  • Michaelis L, Menten M L. Die kinetik der invertinwirkung. Biochemistry 1913; 49: 333–369
  • Hill A V. The combinations of hemoglobin with oxygen and with carbon monoxide. Biochem J 1913; 7: 471–480
  • Scatchard G. The attractions of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660–672
  • Clark W M. The Determination of Hydrogen Ions, 3rd edn. Williams & Wilkins, Baltimore 1928
  • Chou T C, Motzer R J, Tong Y, Bosl G J. Computerized quantitation of synergism and antagonism of Taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 1994; 86: 1517–1524
  • Chou T C, Chou J H. Computerized indexing of drug combinations: prediction of synergism and antagonism of more than two drugs by polygonogram (abstract). FASEB J 1998; 12: 832
  • Mayer L D, Janoff A S. Optimizing combination chemotherapy by controlling drug ratios. Mol Interventions 2007; 7: 216–223
  • Chou T C, Dong H J, Timmermans P BMWM. Design, experimentation and computerized automated data analysis of synergistic drug combinations against xenograft tumors by Taxotere and T-900607. Proc Am Assoc Cancer Res 2005; 46: 1167
  • Chou T C. Drug combination against xenograft tumors in nude mice: experimental design, execution, and computerized simulation of synergism and antagonism (An abstract for the mini-symposium). Proc Am Assoc Cancer Res 2008; 49: p. 997
  • Vogt M W, Hartshorn K L, Furman P A, Chou T C, Fyte J A, Coleman L A, et al. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 1987; 235: 1376–1379

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.