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Letters to the Editor

Little dose, huge toxicity: profound hematological toxicity of intrathecal methotrexate

, , , , &
Pages 282-283 | Received 26 Aug 2008, Accepted 31 Oct 2008, Published online: 01 Jul 2009

References

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  • Bay A, Oner A F, Etlik O, Yilmaz C, Caksen H. Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol 2005; 27: 270–272
  • Gagliano R G, Costanzi J J. Paraplegia following intrathecal methotrexate: report of a case and review of the literature. Cancer 1976; 37: 1663–1668
  • Rubin R, Owens E, Rall D. Transport of methotrexate by the choroid plexus. Cancer Res 1968; 28: 689
  • Bostrom B C, Erdmann G R, Kamen B A. Systemic methotrexate exposure is greater after intrathecal than after oral administration. J Pediatr Hematol Oncol 2003; 25: 114–117

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