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Original Article: Clinical

Genetic polymorphism of the inhibitory IgG Fc receptor FcgammaRIIb is not associated with clinical outcome in patients with follicular lymphoma treated with rituximab

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Pages 723-727 | Received 28 Jan 2009, Accepted 15 Feb 2009, Published online: 21 Jul 2009

References

  • Anderson D R, Grillo-Lopez A, Varns C, Chambers K S, Hanna N. Targeted anti-cancer therapy using rituximab, a chimeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma. Biochem Soc Trans 1997; 25: 705–708
  • Golay J, Zaffaroni L, Vaccari T, Lazzari M, Borleri G-M, Bernasconi S, et al. Biological response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood 2000; 95: 3900–3908
  • Weng W-K, Levy R. Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma. Blood 2001; 98: 1352–1357
  • Manches O, Lui G, Chaperot L, Gressin R, Molens J-P, Jacob M-C, et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood 2003; 101: 949–954
  • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγR IIIa gene. Blood 2002; 99: 754–758
  • Weng W-K, Levy R. Two immunoglobulin G Fc receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 2003; 21: 3940–3947
  • Fanger M W, Shen L, Graziano R F, Guyre P M. Cytotoxicity mediated by human Fc receptors for IgG. Trend Immunol 1989; 10: 92–99
  • Graziano R F, Ranger M W. FcγRI and FcγRII on monocytes and granulocytes are cytotoxic trigger molecules for tumor cells. J Immunol 1987; 139: 3536–3541
  • Koene H R, Kleijer M, Algra J, Roos D, von dem Borne A, de Haas M. FcγRIIIa-158 V/F polymorphism influences the binding of IgG by natural killer cell FcγRIIIa, independently of the FcγRIIIa-48 L/R/H phenotype. Blood 1997; 90: 1109–1114
  • Shields R L, Namenuk A K, Hong K, Meng Y G, Rae J, Briggs J, et al. High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR. J Biol Chem 2001; 276: 6591–6604
  • Vance B A, Huizinga T WJ, Wardwell K, Guyre P M. Binding of monomeric human IgG defines an expression polymorphism of FcγRIII on large granular lymphocyte/natural killer cells. J Immunol 1993; 151: 6429–6439
  • Nimmerjahn F, Ravetch J V. Fcγ receptors: old friends and new family members. Immunity 2006; 24: 19–28
  • Kyogoku C, Dijstelbloem H M, Tsuchiya N, Hatta Y, Yamaguchi A, Fukazawa T, et al. Fcγ receptor gene polymorphism in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 2002; 46: 1242–1254
  • Li X, Wu J, Carter R H, Edberg J C, Su K, Cooper G S, et al. A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis Rheum 2003; 48: 3242–3252
  • Cheson B D, Horning S J, Coiffier B, et al. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphoma. J Clin Oncol 1999; 17: 1244–1253
  • Kopreski M S, Benko F A, Kwee C, Leitzel K E, Eskander E, Lipton A, et al. Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. Br J Cancer 1997; 76: 1293–1299
  • Clynes R A, Towers T L, Presta L G, Ravetch J V. Inhibitory Fc receptor modulate in vivo cytotoxicity against tumor targets. Nature Med 2000; 6: 443–446
  • Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, et al. FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Human Mol Gene 2005; 14: 2881–2892
  • Camilleri-Broet S, Mounier N, Delmer A, Briere J, Casasnovas O, Cassard L, et al. FcγRIIB expression in diffuse large B-cell lymphomas does not alter the response to CHOP + rituximab (R-CHOP). Leukemia 2004; 18: 2038–2040
  • Lejeune J, Thibault G, Ternant D, Cartron G, Watier H, Ohresser M. Evidence for linkage disequilibrium between FcγRIIIa-V158F and FcγRIIA-H131R polymorphisms in white patients, and for an FcγIIIa-restricted influence on the response to therapeutic antibodies. J Clin Oncol 2008; 26: 5489–5491
  • van der Pol W L, Jansen M D, Sluiter W J, van de Sluis B, Leppers-van de Straat F GJ, Kobayashi T, et al. Evidence for non-random distribution of Fcγ receptor genotype combinations. Immunogenetics 2003; 55: 240–246
  • Miescher S, Spycher M O, Amstutz H, de Haas M, Kleijer M, Kalus U J, et al. A single recombinant anti-RhD IgG prevents RhD immunization: association of RhD-positive red blood cell clearance rate with polymorphism in the FcγRIIA and FcγRIIIA genes. Blood 2004; 103: 4028–4035
  • Musolino A, Naldi N, Bortesi B, Pezzuolo D, Capelletti M, Missale G, et al. Immunoglobulin G fragement C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER2/neu-positive metastatic breast cancer. J Clin Oncol 2008; 26: 1789–1796
  • Zhang W, Gordon M, Schultheis A M, Yang D Y, Nagashima F, Azuma M, et al. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor-expression metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol 2007; 25: 3712–3718
  • Weng W-K, Czerwinski D, Timmerman J, Hsu F J, Levy R. Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype. J Clin Oncol 2004; 22: 4717–4724
  • Chu Z T, Tsuchiya N, Kyogoku C, Ohashi J, Wian Y P, Xu S B, et al. Association of Fcγ receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 2004; 63: 21–27

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