The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1

References

• Bain G, Romanow W J, Albers K, Havran W L, Murre C. Positive and negative regulation of V(D)J recombination by the E2A proteins. J Exp Med 1999; 189: 289–300
   PubMed Web of Science ®Google Scholar
• McMurry M T, Krangel M S. A role for histone acetylation in the developmental regulation of VDJ recombination. Science 2000; 287: 495–498
   PubMed Web of Science ®Google Scholar
• Massari M E, Grant P A, Pray-Grant M G, Berger S L, Workman J L, Murre C. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell 1999; 4: 63–73
   PubMed Web of Science ®Google Scholar
• Eckner R, Yao T P, Oldread E, Livingston D M. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev 1996; 10: 2478–2490
   PubMed Web of Science ®Google Scholar
• Qiu Y, Sharma A, Stein R. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 1998; 18: 2957–2964
   PubMed Web of Science ®Google Scholar
• Inaba T, Roberts W M, Shapiro L H, Jolly K W, Raimondi S C, Smith S D, et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 1992; 257: 531–534
   PubMed Web of Science ®Google Scholar
• Kamps M P, Look A T, Baltimore D. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991; 5: 358–368
   PubMed Web of Science ®Google Scholar
• Van Dijk M A, Voorhoeve P M, Murre C. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc Natl Acad Sci USA 1993; 90: 6061–6065
   PubMedGoogle Scholar
• Lu Q, Wright D D, Kamps M P. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol Cell Biol 1994; 14: 3938–3948
   PubMedGoogle Scholar
• Monica K, LeBrun D P, Dedera D A, Brown R, Cleary M L. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol Cell Biol 1994; 14: 8304–8314
   PubMed Web of Science ®Google Scholar
• Redner R L, Wang J, Liu J M. Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 1999; 94: 417–428
   PubMed Web of Science ®Google Scholar
• Rebel V I, Kung A L, Tanner E A, Yang H, Bronson R T, Livingston D M. Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci USA 2002; 99: 14789–14794
   PubMed Web of Science ®Google Scholar
• Giordano A, Avantaggiati M L. p300 and CBP: partners for life and death. J Cell Physiol 1999; 181: 218–230
   PubMed Web of Science ®Google Scholar
• Kamps M P, Wright D D, Lu Q. DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation. Oncogene 1996; 12: 19–30
   PubMed Web of Science ®Google Scholar
• Monica K, LeBrun D P, Dedera D A, Brown R, Cleary M L. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol Cell Biol 1994; 14: 8304–8314
   PubMed Web of Science ®Google Scholar
• Bayly R, LeBrun D P. Role for homodimerization in growth deregulation by E2a fusion proteins. Mol Cell Biol 2000; 20: 5789–5796
   PubMed Web of Science ®Google Scholar
• Bork P, Sander C. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor. FEBS Lett 1992; 300: 237–240
   PubMed Web of Science ®Google Scholar
• Lambert C, Brealey R, Steele J, Rook G A. The interaction of Tamm-Horsfall protein with the extracellular matrix. Immunology 1993; 79: 203–210
   PubMed Web of Science ®Google Scholar
• Muchmore A V, Decker J M. Evidence that recombinant IL 1 alpha exhibits lectin-like specificity and binds to homogeneous uromodulin via N-linked oligosaccharides. J Immunol 1987; 138: 2541–2546
   PubMed Web of Science ®Google Scholar
• Sherblom A P, Decker J M, Muchmore A V. The lectin-like interaction between recombinant tumor necrosis factor and uromodulin. J Biol Chem 1988; 263: 5418–5424
   PubMed Web of Science ®Google Scholar
• Yamashita T, Yoshioka M, Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 2000; 277: 494–498
   PubMed Web of Science ®Google Scholar
• McWhirter J R, Goulding M, Weiner J A, Chun J, Murre C. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 1997; 124: 3221–3232
   PubMed Web of Science ®Google Scholar
• Itoh N, Ornitz D M. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 2008; 237: 18–27
   PubMed Web of Science ®Google Scholar
• Vincentz J W, McWhirter J R, Murre C, Baldini A, Furuta Y. Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis 2005; 41: 192–201
   PubMed Web of Science ®Google Scholar
• Inagaki T, Choi M, Moschetta A, Peng L, Cummins C L, McDonald J G, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217–225
   PubMed Web of Science ®Google Scholar
• Calvo K R, Knoepfler P, McGrath S, Kamps M P. An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1. Oncogene 1999; 18: 8033–8043
   PubMed Web of Science ®Google Scholar
• Sykes D B, Kamps M P. Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. Blood 2001; 98: 2308–2318
   PubMed Web of Science ®Google Scholar
• Fu X, Kamps M P. E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol 1997; 17: 1503–1512
   PubMed Web of Science ®Google Scholar
• Church G M, Gilbert W. Genomic sequencing. Proc Natl Acad Sci USA 1984; 81: 1991–1995
   PubMed Web of Science ®Google Scholar
• Knoepfler P S, Lu Q, Kamps M P. Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3′ to a TAAT motif. Nucleic Acids Res 1996; 24: 2288–2294
   PubMed Web of Science ®Google Scholar
• Daley G Q, Van Etten R A, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824–830
   PubMed Web of Science ®Google Scholar
• Gesteland R F, Atkins J F. Recoding: dynamic reprogramming of translation. Annu Rev Biochem 1996; 65: 741–768
   PubMed Web of Science ®Google Scholar
• Waterston R H, Lindblad-Toh K, Birney E, Rogers J, Abril J F, Agarwal P, et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002; 420: 520–562
   PubMed Web of Science ®Google Scholar
• Nielsen H, Engelbrecht J, Brunak S, von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng 1997; 10: 1–6
   PubMedGoogle Scholar
• Neuteboom S T, Murre C. Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins. Mol Cell Biol 1997; 17: 4696–4706
   PubMed Web of Science ®Google Scholar
• Ron D, Tronick S R, Aaronson S A, Eva A. Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells. EMBO J 1988; 7: 2465–2473
   PubMed Web of Science ®Google Scholar