Advanced search
Publication Cover
Leukemia & Lymphoma Volume 59, 2018 - Issue 1
Submit an article Journal homepage
189
Views
1
CrossRef citations to date
0
Altmetric
Letters to the Editor

Identification of a novel KMT2A–SEPT14 fusion in acute myeloid leukemia

Doreen NguyenDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
,
Lisa HaleyDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
,
Aparna PallavajjalaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
,
Ivana GojoDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
&
Yi NingDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Correspondence[email protected]
Pages 265-267 | Received 11 Mar 2017, Accepted 22 Apr 2017, Published online: 02 Jun 2017

References

  • Rao RC, Dou Y. Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 2015;15:334–346.
  • Gole B, Wiesmüller L. Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism. Front Cell Dev Biol. 2015;3:41.
  • Harper DP, Aplan PD. Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects. Cancer Res. 2008;68:10024–10027.
  • Muntean AG, Hess JL. The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol. 2012;7:283–301.
  • Marschalek R. Systematic classification of mixed-lineage leukemia fusion partners predicts additional cancer pathways. Ann Lab Med. 2016;36:85–100.
  • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368:2059–2074.
  • Forbes SA, Beare D, Gunasekaran P, et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 2015;43:D805–D811.
  • Nikoloski G, Langemeijer SM, Kuiper RP, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet. 2010;42:665–667.
  • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010;42:722–726.
  • Cerveira N, Bizarro S, Teixeira MR. MLL–SEPTIN gene fusions in hematological malignancies. Biol Chem. 2011;392:713–724.
  • Peterson EA, Kalikin LM, Steels JD, et al. Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. Mamm Genome. 2007;18:796–807.
  • Frattini V, Trifonov V, Chan JM, et al. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet. 2013;45:1141–1149.
  • Bridges AA, Gladfelter AS. Septin form and function at the cell cortex. J Biol Chem. 2015;290:17173–17180.
  • Poüs C, Klipfel L, Baillet A. Cancer-related functions and subcellular localizations of septins. Front Cell Dev Biol. 2016;4:126.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.