Advanced search
Publication Cover
Leukemia & Lymphoma Volume 59, 2018 - Issue 4
Submit an article Journal homepage
270
Views
15
CrossRef citations to date
0
Altmetric
Letters to the Editor

Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

Lasse KjaerDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; Correspondence[email protected]
View further author information
,
Morten O. HolmströmDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; ;Center for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Herlev, Denmark; View further author information
,
Sabrina CorduaDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; View further author information
,
Mads Hald AndersenCenter for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Herlev, Denmark; View further author information
,
Inge Marie SvaneCenter for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Herlev, Denmark; View further author information
,
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark; View further author information
,
Torben A KruseDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark; View further author information
,
Niels PallisgaardDepartment of Surgical Pathology, Zealand University Hospital, Roskilde, DenmarkView further author information
,
Vibe SkovDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; View further author information
&
Hans C. HasselbalchDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; View further author information
 show all
Pages 973-977 | Received 23 May 2017, Accepted 16 Jul 2017, Published online: 09 Aug 2017

References

  • Langabeer SE, Andrikovics H, Asp J, et al. Molecular diagnostics of myeloproliferative neoplasms. Eur J Haematol. 2015;95:270–279.
  • Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379–2390.
  • Araki M, Yang Y, Masubuchi N, et al. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood. 2016;127:1307–1316.
  • Martin S, Wright CM, Scott LM. Progenitor genotyping reveals a complex clonal architecture in a subset of CALR-mutated myeloproliferative neoplasms. Br J Haematol. 2017;177:55–66.
  • Larsen TS, Christensen JH, Hasselbalch HC, et al. The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders. Br J Haematol. 2007;136:745–751.
  • Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391–2405.
  • Scott LM, Scott MA, Campbell PJ, et al. Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood. 2006;108:2435–2437.
  • Godfrey AL, Chen E, Pagano F, et al. JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone. Blood. 2012;120:2704–2707.
  • Jeromin S, Kohlmann A, Meggendorfer M, et al. Next-generation deep-sequencing detects multiple clones of CALR mutations in patients with BCR-ABL1 negative MPN. Leukemia. 2016;30:973–976.
  • Rumi E, Pietra D, Ferretti V, et al. JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes. Blood. 2014;123:1544–1551.
  • Kjaer L, Westman M, Hasselbalch Riley C, et al. A highly sensitive quantitative real-time PCR assay for determination of mutant JAK2 exon 12 allele burden. PLoS One. 2012;7:e33100.
  • Kjaer L, Cordua S, Holmstrom MO, et al. Differential dynamics of CALR mutant allele burden in myeloproliferative neoplasms during interferon alfa treatment. PLoS One. 2016;11:e0165336.
  • Holmstrom MO, Riley CH, Svane IM, et al. The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms. Leukemia. 2016;30:2413–2416.
  • Raghavan M, Wijeyesakere SJ, Peters LR, et al. Calreticulin in the immune system: ins and outs. Trends Immunol. 2013;34:13–21.
  • Scott LM. The JAK2 exon 12 mutations: a comprehensive review. Am J Hematol. 2011;86:668–676.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.