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Leukemia & Lymphoma Volume 59, 2018 - Issue 5
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Original Articles: Research

All-trans retinoic acid induces autophagic degradation of ubiquitin-like modifier activating enzyme 3 in acute promyelocytic leukemia cells

Huanling CaoDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China; ;Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China;
,
Jing XieCenter of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China;
,
Lu GuoDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China; ;Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China;
,
Kun HanDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Yujun PeiDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Xin LiDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Guihua QiuDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Jiayang JinDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Lei HuaDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Zhaofei JingDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Huifang WuDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China; ;Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China;
,
Jian LiuDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Jing WangDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Beifen ShenDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Suoqin TangDepartment of Pediatrics, General Hospital of People's Liberation Army, Beijing, China
,
Jiyan ZhangDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China;
,
Jun ZhangJoint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China; Correspondence[email protected]
,
Hu ChenCenter of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China; Correspondence[email protected]
&
Qingyang WangDepartment of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China; Correspondence[email protected]
 show all
Pages 1222-1230 | Received 16 Jan 2017, Accepted 29 Jul 2017, Published online: 29 Aug 2017

References

  • Licht JD. Acute promyelocytic leukemia-weapons of mass differentiation. N Engl J Med. 2009;360:928–930.
  • Isakson P, Bjoras M, Boe SO, et al. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. 2010;116:2324–2331.
  • Wang Z, Cao L, Kang R, et al. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein. Autophagy. 2011;7:401–411.
  • Brigger D, Proikas-Cezanne T, Tschan MP. WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell Death Dis. 2014;5:e1315.
  • Lee KH, Chang MY, Ahn JI, et al. Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells. Biochem Biophys Res Commun. 2002;296:1125–1133.
  • Gong L, Yeh ET. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999;274:12036–12042.
  • Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol. 2006;22:159–180.
  • Soucy TA, Smith PG, Milhollen MA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009;458:732–736.
  • Read MA, Brownell JE, Gladysheva TB, et al. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol. 2000;20:2326–2333.
  • Saha A, Deshaies RJ. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell. 2008;32:21–31.
  • Yu ZK, Gervais JL, Zhang H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci USA. 1998;95:11324–11329.
  • Enchev RI, Schulman BA, Peter M. Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol. 2015;16:30–44.
  • Xirodimas DP. Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem Soc Trans. 2008;36:802–806.
  • Gu Y, Kaufman JL, Bernal L, et al. MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells. Bolld. 2014;123:3269–3276.
  • Milhollen MA, Traore T, Adams-Duffy J, et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood. 2010;116:1515–1523.
  • Han K, Wang Q, Cao H, et al. The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget. 2016;7:23812–23824.
  • Swords RT, Kelly KR, Smith PG, et al. Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood. 2010;115:3796–3800.
  • van Dongen JJ, Macintyre EA, Gabert JA, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 concerted action: investigation of minimal residual disease in acute leukemia. Leukemia. 1999;13:1901–1928.
  • Hjerpe R, Thomas Y, Chen J, et al. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochem J. 2012;441:927–936.
  • Wu J, Dang Y, Su W, et al. Molecular cloning and characterization of rat LC3A and LC3B-two novel markers of autophagosome. Biochem Biophys Res Commun. 2006;339:437–442.
  • Duda DM, Borg LA, Scott DC, et al. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell. 2008;134:995–1006.
  • Petroski MD, Deshaies RJ. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol. 2005;6:9–20.
  • Collins SJ. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood. 1987;70:1233–1244.
  • Barber N, Belov L, Christopherson RI. All-trans retinoic acid induces different immunophenotypic changes on human HL60 and NB4 myeloid leukaemias. Leuk Res. 2008;32:315–322.
  • Kropf PL, Wang L, Zang Y, et al. Dasatinib promotes ATRA-induced differentiation of AML cells. Leukemia. 2010;24:663–665.

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