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Leukemia & Lymphoma Volume 59, 2018 - Issue 9
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Letter to the Editor

Surface endoglin (CD105) expression on acute leukemia blast cells: an extensive flow cytometry study of 1002 patients

Vincenzo CosimatoCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Giulia ScaliaCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Maddalena RaiaCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Laura GentileCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Vincenza CerboneCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Feliciano VisconteCEINGE Biotecnologie Avanzate, Naples, Italy;
,
Teodora StatutoLaboratory of Clinical Research and Advanced Diagnostics, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy;
,
Luciana ValvanoLaboratory of Clinical Research and Advanced Diagnostics, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy;
,
Fiorella D’AuriaLaboratory of Clinical Research and Advanced Diagnostics, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy;
,
Giovanni CaliceLaboratory of Clinical Research and Advanced Diagnostics, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy;
,
Daniela GrazianoAntonio Cardarelli Hospital, Unit of Transfusional Medicine, Naples, Italy;
,
Pellegrino MustoScientific Direction, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy; Correspondence[email protected]
&
Luigi Del VecchioCEINGE Biotecnologie Avanzate, Naples, Italy; ;Department of Molecular Medicine and Medical Biotechnologies (DMMBM), Federico II University, Naples, Italy
 show all
Pages 2242-2245 | Received 21 Sep 2017, Accepted 05 Dec 2017, Published online: 15 Jan 2018

References

  • Fonsatti E, Sigalotti L, Arslan P, et al. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies. Curr Cancer Drug Targets. 2003;3:427–432.
  • Fonsatti E, Nicolay HJ, Altomonte M, et al. Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours. Cardiovasc Res. 2010; 86:12–19.
  • Bühring HJ, Müller CA, Letarte M, et al. Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow. Leukemia. 1991;5:841–847.
  • Rokhlin OW, Cohen MB, Kubagawa H, et al. Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J Immunol. 1995;154:4456–4465.
  • Chen CZ, Li M, de Graaf D, et al. Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci Usa. 2002;99:15468–15473.
  • Dourado KMC, Baik J, Oliveira VKP, et al. Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models. Blood. 2017;129:2526–2536.
  • Pierelli L, Scambia G, Bonanno G, et al. CD34+/CD105+ cells are enriched in primitive circulating progenitors residing in the G0 phase of the cell cycle and contain all bone marrow and cord blood CD34+/CD38low/- precursors. Br J Haematol. 2000;108:610–620.
  • Della Porta MG, Malcovati L, Invernizzi R, et al. Flow cytometry evaluation of erythroid dysplasia in patients with myelodysplastic syndrome. Leukemia. 2006;20:549–555.
  • Chakhachiro ZI, Zuo Z, Aladily TN, et al. CD105 (endoglin) is highly overexpressed in a subset of cases of acute myeloid leukemias. Am J Clin Pathol. 2013;140:370–378.
  • Dejana E, Orsenigo F. Endothelial adherens Junctions at a glance. J Cell Sci. 2013;126:2545–2549.
  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–2405.
  • Ferrara F, Del Vecchio L. Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity. Haematologica. 2002;87:306–319.
  • Di Noto R, Mirabelli P, Del Vecchio L. Flow cytometry analysis of acute promyelocytic leukemia: the power of 'surface hematology'. Leukemia. 2007;21:4–8.
  • Martelli MP, Pettirossi V, Thiede C, et al. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood. 2010;116:3907–3922.
  • Ferrara F, Cimino R, Antinolfi I, et al. Clinical relevance of immunological dissection in T-ALL: a report on 20 cases with stem cell (CD7+, CD4-, CD8-, CD1-) phenotype. Am J Hematol. 1992;40:98–102.

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