Vibsanol A induces differentiation of acute myeloid leukemia cells via activation of the PKC signaling pathway and induction of ROS

References

• McCulloch E. Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982). Blood. 1983;62:1–13.
   PubMed Web of Science ®Google Scholar
• Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008;111: 2505–2515.
   PubMed Web of Science ®Google Scholar
• Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood. 2009;113:3655–3665.
   PubMed Web of Science ®Google Scholar
• Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer. 2007;7:281–294.
   PubMed Web of Science ®Google Scholar
• Koeffler HP, Bar-Eli M, Territo M. Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia. J Clin Invest. 1980;66:1101–1108.
   PubMed Web of Science ®Google Scholar
• Han ZT, Zhu XX, Yang RY, et al. Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity. Proc Natl Acad Sci USA. 1998;95:5357–5361.
   PubMed Web of Science ®Google Scholar
• Hampson P, Chahal H, Khanim F, et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood. 2005;106:1362–1368.
   PubMed Web of Science ®Google Scholar
• Olsnes AM, Ersvaer E, Ryningen A, et al. The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells. Br J Haematol. 2009;145:761–774.
   PubMed Web of Science ®Google Scholar
• Shen X, Xiong GL, Jing Y, et al. The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 2015;356:686–696.
   PubMed Web of Science ®Google Scholar
• Miranda MB, Johnson DE. Signal transduction pathways that contribute to myeloid differentiation. Leukemia. 2007;21:1363–1377.
   PubMed Web of Science ®Google Scholar
• Yu Z, Xiao H, Wang L, et al. Natural product vibsanin A induces differentiation of myeloid leukemia cells through PKC activation. Cancer Res. 2016;76: 2698–2709.
   PubMed Web of Science ®Google Scholar
• Jacquel A, Herrant M, Defamie V, et al. A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis. Oncogene. 2006;25:781–794.
   PubMed Web of Science ®Google Scholar
• Hole PS, Darley RL, Tonks A. Do reactive oxygen species play a role in myeloid leukemias? Blood. 2011; 117:5816–5826.
   PubMed Web of Science ®Google Scholar
• Yang L, Chai W, Wang Y, et al. Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy. Am J Cancer Res. 2015;5:714–725.
   PubMed Web of Science ®Google Scholar
• Ojima Y, Duncan MT, Nurhayati RW, et al. Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA. Exp Cell Res. 2013;319:2205–2215.
   PubMed Web of Science ®Google Scholar
• Callens C, Coulon S, Naudin J, et al. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010;207:731–750.
   PubMed Web of Science ®Google Scholar
• Liu CX, Yin QQ, Zhou HC, et al. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol. 2012;8:486–493.
   PubMed Web of Science ®Google Scholar
• Wang R, Xia L, Gabrilove JL, et al. Sorafenib inhibition of Mcl-1 accelerates ATRA induced apoptosis in differentiation responsive AML cells. Clin Cancer Res. 2016;22:1211–1221.
   PubMed Web of Science ®Google Scholar
• Kawazu K. Isolation of vibsanines A, B, C, D, E and F from Viburnum odoratissimum. Agric Biol Chem. 1980;44:1367–1372.
   Web of Science ®Google Scholar
• Shen YC, Prakash CV, Wang LT, et al. New vibsane diterpenes and lupane triterpenes from Viburnum odoratissimum. J Nat Prod. 2002;65:1052–1055.
   PubMed Web of Science ®Google Scholar
• He J, Peng LY, Tu L, et al. Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum. Fitoterapia. 2016;109:224–229.
   PubMed Web of Science ®Google Scholar
• Xu JP. Cancer inhibitors from Chinese natural medicines. Boca Raton (FL): CRC Press; 2017.
   Google Scholar
• Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501–1512.
   PubMed Web of Science ®Google Scholar
• Matatall KA, Shen CC, Challen GA, et al. Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Stem Cells. 2014;32:3023–3030.
   PubMed Web of Science ®Google Scholar
• Yan Y, Hanse EA, Stedman K, et al. Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells. Cell Death Differ. 2016; 23:1232–1242.
   PubMed Web of Science ®Google Scholar
• Kedei N, Lundberg DJ, Toth A, et al. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res. 2004;64:3243–3255.
   PubMed Web of Science ®Google Scholar
• Choi SH, Hyman T, Blumberg PM. Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase C delta. Cancer Res. 2006;66: 7261–7269.
   PubMed Web of Science ®Google Scholar
• Ye BX, Deng X, Shao LD, et al. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2015;194:4489–4497.
   PubMed Web of Science ®Google Scholar
• Matsuki W, Miyazaki S, Yoshida K, et al. Synthesis and evaluation of biological activities of vibsanin A analogs. Bioorg Med Chem Lett. 2017;27:4536–4539.
   PubMedGoogle Scholar
• Buttitta L, Edgar B. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol. 2007;19:697–704.
   PubMed Web of Science ®Google Scholar
• Miranda MB, McGuire TF, Johnson DE. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia. 2002;16:683–692.
   PubMed Web of Science ®Google Scholar
• Bae YS, Oh H, Rhee SG, et al. Regulation of reactive oxygen species generation in cell signaling. Mol Cells. 2011;32:491–509.
   PubMed Web of Science ®Google Scholar
• Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24:981–990.
   PubMed Web of Science ®Google Scholar
• Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood. 2007;110:3056–3063.
   PubMed Web of Science ®Google Scholar
• Abdel-Wahab O, Levine RL. Metabolism and the leukemic stem cell. J Exp Med. 2010;207:677–680.
   PubMed Web of Science ®Google Scholar
• Yu ZY, Liang YG, Xiao H, et al. Melissoidesin G, a diterpenoid purified from Isodon melissoides, induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents. Int J Cancer. 2007;121:2084–2094.
   PubMed Web of Science ®Google Scholar
• Radominska-Pandya A, Chen G, Czernik PJ, et al. Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy. J Biol Chem. 2000;275:22324–22330.
   PubMed Web of Science ®Google Scholar