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Leukemia & Lymphoma Volume 59, 2018 - Issue 11
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Letter to the Editor

An unusual, CD4 and CD8 dual-positive, CD25 negative, tumor cell phenotype in a patient with adult T-cell leukemia/lymphoma

Nicholas CaseyDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6706-8710
ORCID Icon,
Hiroshi FujiwaraDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan; Correspondence[email protected]
,
Taichi AzumaDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan;
,
Yuichi MurakamiDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan;
,
Makoto YoshimitsuDepartment of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan;
,
Izumi MasamotoClinical Laboratory, Kagoshima University Hospital, Kagoshima, Japan;
,
Yuichiro NawaDivision of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan;
,
Jun YamanouchiDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan;
,
Hiroshi NarumiDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan;
,
Yoshihiro YakushijinCancer Center of Ehime University Hospital, Ehime University Graduate School of Medicine, Toon, Japan;
,
Takaaki HatoDepartment of Blood Transfusion and Cell Therapy, Ehime University Graduate School of Medicine, Toon, Japan
&
Masaki YasukawaDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan;
show all
Pages 2740-2742 | Received 02 Nov 2017, Accepted 01 Feb 2018, Published online: 21 Feb 2018

References

  • Takatsuki K. Adult T-cell leukemia. Intern Med. 1995;34:947–952.
  • Floess S, Freyer J, Siewert C, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007;5:e38.
  • Huehn J, Polansky JK, Hamann A. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol. 2009;9:83–89.
  • Kamihira S, Sohda H, Atogami S, et al. Phenotypic diversity and prognosis of adult T-cell leukemia. Leukemia Res. 1992;16:435–441.
  • Uchiyama T, Hori T, Tsudo M, et al. Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J Clin Invest. 1985;76:446–453.
  • Kohno T, Yamada Y, Akamatsu N, et al. Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci. 2005;96:527–533.
  • Yamada Y. Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma. Blood. 1983;61:192–199.
  • Walker MR, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25− T cells. J Clin Investig. 2003;112:1437–1443.
  • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057–1061.
  • Hasegawa H, Sawa H, Lewis MJ, et al. Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I . Nat Med. 2006;12:466–472.
  • Baron U, Floess S, Wieczorek G, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol. 2007;37:2378–2389.
  • Shimazu Y, Shimazu Y, Hishizawa M, et al. Hypomethylation of the Treg-specific demethylated region in FOXP3 is a hallmark of the regulatory T-cell subtype in adult T-cell leukemia. Cancer Immunol Res. 2016;4:136–145.
  • Parel Y, Chizzolini C. CD4+ CD8+ double positive (DP) T cells in health and disease. Autoimmun Rev. 2004;3:215–220.
  • Ishitsuka K, Tamura K. Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma. Lancet Oncol. 2014;15:e517–e526.

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