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Leukemia & Lymphoma Volume 61, 2020 - Issue 1
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Letter to the Editor

Co-occurrence of BCR-ABL1 rearrangement and CALR mutation in a single leukemic stem cell: evidence that BCR-ABL1 oncogenic addiction prevails over CALR signaling

Estelle BalducciINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France; ORCID Iconhttp://orcid.org/0000-0001-6792-1291
ORCID Icon,
Safa SanekliINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France;
,
Patricia HuguesINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France;
,
Mathis SoubeyrandINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France;
,
Claire BorieAssistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France;
,
Xavier FundAssistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France;
,
Christophe DesterkeINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France;
,
Cédric AumontAssistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France;
,
Jamila FaivreAssistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France; ;INSERM, UMR 785, Centre Hépato-Biliaire, Villejuif, France;
,
Annelise Bennaceur-GriscelliINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France; ;INGESTEM-ESteam Pluripotent Stem Cell Infrastructure, Villejuif, France
&
Ali G. TurhanINSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Paul Brousse, Villejuif, France; ;Assistance Publique-Hôpitaux de Paris, Service D’Hématologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France; ;INGESTEM-ESteam Pluripotent Stem Cell Infrastructure, Villejuif, FranceCorrespondence[email protected]
 show all
Pages 209-212 | Received 24 Jun 2019, Accepted 10 Aug 2019, Published online: 29 Aug 2019

References

  • O’Brien S, Thall PF, Siciliano MJ. Cytogenetics of chronic myelogenous leukaemia. Baillieres Clin Haematol. 1997;10:259–276.
  • Helbig G. Classical Philadelphia-negative myeloproliferative neoplasms: focus on mutations and JAK2 inhibitors. Med Oncol Northwood Lond Engl. 2018;35:119.
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  • Cabagnols X, Cayuela J-M, Vainchenker W. A CALR mutation preceding BCR-ABL1 in an atypical myeloproliferative neoplasm. N Engl J Med. 2015;372:688–690.
  • Seghatoleslami M, Ketabchi N, Ordo A, et al. Coexistence of p190 BCR/ABL transcript and CALR 52-bp deletion in chronic myeloid leukemia blast crisis: a case report. Mediterr J Hematol Infect Dis. 2016;8:e2016002.
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  • Diamond JMS, de Almeida AM, Belo H, et al. CALR-mutated primary myelofibrosis evolving to chronic myeloid leukemia with both CALR mutation and BCR-ABL1 fusion gene. Ann Hematol. 2016;95:2101–2104.
  • Boddu P, Chihara D, Masarova L, et al. The co-occurrence of driver mutations in chronic myeloproliferative neoplasms. Ann Hematol. 2018;97:2071–2080.
  • Loghavi S, Pemmaraju N, Kanagal-Shamanna R, et al. Insights from response to tyrosine kinase inhibitor therapy in a rare myeloproliferative neoplasm with CALR mutation and BCR-ABL1. Blood. 2015;125:3360–3363.
  • Dogliotti I, Fava C, Serra A, et al. CALR-positive myeloproliferative disorder in a patient with Ph-positive chronic myeloid leukemia in durable treatment-free remission: a case report. Stem Cell Investig. 2017;4:57.
  • Choi SM, Goldenson B, Peterson LA, et al. Diagnostic and therapeutic implications of genetic heterogeneity in myeloid neoplasms uncovered by comprehensive mutational analysis. Leuk Res Rep. 2017;8:11–13.

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