Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting

References

• Coleman CB, Daud II, Ogolla SO, et al. Epstein-Barr virus type 2 infects t cells in healthy Kenyan children. J Infect Dis. 2017;216:670–677.
   PubMed Web of Science ®Google Scholar
• Hudnall SD, Ge Y, Wei L, et al. Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsils. Mod Pathol. 2005;18:519–527.
   PubMed Web of Science ®Google Scholar
• Bekker V, Scherpbier H, Beld M, et al. Epstein-Barr virus infects B and non-B lymphocytes in HIV-1-infected children and adolescents. J Infect Dis. 2006;194:1323–1330.
   PubMed Web of Science ®Google Scholar
• Calattini S, Sereti I, Scheinberg P, et al. Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders by using Immuno-FISH. Blood. 2010;116:4546–4559.
   PubMed Web of Science ®Google Scholar
• Jaffe ES, Harris NL, Stein H, et al. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon (France): IARC Press; 2001.
   Google Scholar
• Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues revised. 4th ed. Lyon (France): International Agency for Research on Cancer (IARC); 2017.
   Google Scholar
• Kimura H, Ito Y, Kawabe S, et al. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood. 2012;119:673–686.
   PubMed Web of Science ®Google Scholar
• Hong M, Ko YH, Yoo KH, et al. EBV-positive T/NK-cell lymphoproliferative disease of childhood. Korean J Pathol. 2013;47:137–147.
   PubMed Web of Science ®Google Scholar
• Gao J, Behdad A, Ji P, et al. EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution. Mod Pathol. 2017;30:1100–1115.
   PubMed Web of Science ®Google Scholar
• Nicolae A, Ganapathi KA, Pham TH, et al. EBV-negative aggressive NK-cell leukemia/lymphoma: clinical, pathologic, and genetic features. Am J Surg Pathol. 2017;41:67–74.
   PubMed Web of Science ®Google Scholar
• Ko YH, Park S, Kim K, et al. Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis? Acta Haematol. 2008;120:199–206.
   PubMed Web of Science ®Google Scholar
• Park JA, Jun KR, Nam SH, et al. Favorable outcome in a child with EBV-negative aggressive NK cell leukemia. Int J Hematol. 2013;97:673–676.
   PubMed Web of Science ®Google Scholar
• Nakashima Y, Tagawa H, Suzuki R, et al. Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type. Genes Chromosom Cancer. 2005;44:247–255.
   PubMed Web of Science ®Google Scholar
• Jaffe ES, Chan JK, Su IJ, et al. Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell Lymphomas. Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol. 1996;20:103–111.
   PubMed Web of Science ®Google Scholar
• Chan JKC, Sin VC, Wong KF, et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. Blood. 1997;89:4501–4513.
   PubMed Web of Science ®Google Scholar
• Hsiao CH, Lee WI, Chang SL, et al. Angiocentric T-cell lymphoma of the intestine: a distinct etiology of ischemic bowel disease. Gastroenterology. 1996;110:985–990.
   PubMed Web of Science ®Google Scholar
• Au WY, Weisenburger DD, Intragumtornchai T, et al. Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood. 2009;113:3931–3937.
   PubMed Web of Science ®Google Scholar
• Smith MC, Cohen DN, Greig B, et al. The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder. Int J Clin Exp Pathol. 2014;7:5738–5749.
   PubMed Web of Science ®Google Scholar
• Kogawa K, Sato H, Asano T, et al. Prognostic factors of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report of the Japan Histiocytosis Study Group. Pediatr Blood Cancer. 2014;61:1257–1262.
   PubMed Web of Science ®Google Scholar
• Straus SE. Acute progressive Epstein-Barr virus infections. Annu Rev Med. 1992;43:437–449.
   PubMed Web of Science ®Google Scholar
• Cohen JI, Kimura H, Nakamura S, et al. Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008. Ann Oncol. 2009;20:1472–1482.
   PubMed Web of Science ®Google Scholar
• Kimura H, Hoshino Y, Kanegane H, et al. Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. Blood. 2001;98:280–286.
   PubMed Web of Science ®Google Scholar
• Wang RC, Chang ST, Hsieh YC, et al. Spectrum of Epstein-Barr virus-associated T-cell lymphoproliferative disorder in adolescents and young adults in Taiwan. Int J Clin Exp Pathol. 2014;7:2430–2437.
   PubMed Web of Science ®Google Scholar
• Cohen JI. Primary immunodeficiencies associated with EBV disease. Curr Top Microbiol Immunol. 2015;390:241–265.
   PubMed Web of Science ®Google Scholar
• Barrionuevo C, Anderson VM, Zevallos-Giampietri E, et al. Hydroa-like cutaneous T-cell lymphoma: a clinicopathologic and molecular genetic study of 16 pediatric cases from Peru. Appl Immunohistochem Mol Morphol. 2002;10:7–14.
   PubMedGoogle Scholar
• Quintanilla-Martinez L, Ridaura C, Nagl F, et al. Hydroa vacciniforme-like lymphoma: a chronic EBV + lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 2013;122:3101–3110.
   PubMed Web of Science ®Google Scholar
• Liu Y, Ma C, Wang G, et al. Hydroa vacciniforme-like lymphoproliferative disorder: Clinicopathologic study of 41 cases. J Am Acad Dermatol. 2019;81:534–540.
   PubMed Web of Science ®Google Scholar
• Ishihara S, Yabuta R, Tokura Y, et al. Hypersensitivity to mosquito bites is not an allergic disease, but an Epstein-Barr virus-associated lymphoproliferative disease. Int J Hematol. 2000;72:223–228.
   PubMed Web of Science ®Google Scholar
• Tokura Y, Ishihara S, Tagawa S, et al. Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. J Am Acad Dermatol. 2001;45:569–578.
   PubMed Web of Science ®Google Scholar
• Quintanilla-Martinez L, Fend F. Deciphering hydroa vacciniforme. Blood. 2019;133:2735–2737.
   PubMed Web of Science ®Google Scholar
• Quintanilla-Martinez L, Kumar S, Fend F, et al. Fulminant EBV(+) T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome. Blood. 2000;96:443–451.
   PubMed Web of Science ®Google Scholar
• Ohshima K, Kimura H, Yoshino T, et al. Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. Pathol Int. 2008;58:209–217.
   PubMed Web of Science ®Google Scholar
• Attygalle AD, Cabecadas J, Gaulard P, et al. Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward - report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology. Histopathology. 2014;64:171–199.
   PubMed Web of Science ®Google Scholar
• Lee MY, Tan TD, Feng AC, et al. Clinicopathological analysis of malignant lymphoma in Taiwan, defined according to the World Health Organization classification. Haematologica. 2005;90:1703–1705.
   PubMed Web of Science ®Google Scholar
• Lymphoma Study Group of Japanese Pathologists. The World Health Organization classification of malignant lymphomas in Japan: incidence of recently recognized entities. Pathol Int. 2000;50:696–702.
   PubMed Web of Science ®Google Scholar
• Kim JM, Ko YH, Lee SS, et al. WHO classification of malignant lymphomas in Korea: report of the Third Nationwide Study. Korean J Pathol. 2011;45:254–260.
   Web of Science ®Google Scholar
• Yang QP, Zhang WY, Yu JB, et al. Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution. Diagn Pathol. 2011;6:77.
   PubMed Web of Science ®Google Scholar
• Cho EY, Kim KH, Kim WS, et al. The spectrum of Epstein-Barr virus-associated lymphoproliferative disease in Korea: incidence of disease entities by age groups. J Korean Med Sci. 2008;23:185–192.
   PubMed Web of Science ®Google Scholar
• Paik JH, Choe JY, Kim H, et al. Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications. Leuk Lymphoma. 2017;58:53–63.
   PubMed Web of Science ®Google Scholar
• Lee TH, Ko YH. Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea. Bol Med Hosp Infant Mex. 2016;73:10–17.
   PubMed Web of Science ®Google Scholar
• Park S, Kim K, Kim WS, et al. Systemic EBV + T-cell lymphoma in elderly patients: comparison with children and young adult patients. Virchows Arch. 2008;453:155–163.
   PubMed Web of Science ®Google Scholar
• Huh SY, Choi M, Cho KH. A case of Epstein-Barr virus-associated hydroa vacciniforme. Ann Dermatol. 2009;21:209–212.
   PubMed Web of Science ®Google Scholar
• Cho KH, Lee SH, Kim CW, et al. Epstein-Barr virus-associated lymphoproliferative lesions presenting as a hydroa vacciniforme-like eruption: an analysis of six cases. Br J Dermatol. 2004;151:372–380.
   PubMed Web of Science ®Google Scholar
• Cho KH, Choi WW, Youn CS, et al. Skin is the frequent site for involvement of peripheral T-cell and natural killer cell lymphomas in Korea. J Dermatol. 2000;27:500–507.
   PubMedGoogle Scholar
• Cho KH, Kim CW, Kwon OS, et al. Epstein-Barr virus-associated lymphoproliferative eruption with progression to large granular lymphocytic leukaemia. Br J Dermatol. 1997;137:426–430.
   PubMed Web of Science ®Google Scholar
• Cho KH, Kim CW, Lee DY, et al. An Epstein-Barr virus-associated lymphoproliferative lesion of the skin presenting as recurrent necrotic papulovesicles of the face. Br J Dermatol. 1996;134:791–796.
   PubMed Web of Science ®Google Scholar
• Kawamoto K, Miyoshi H, Suzuki T, et al. A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features. Haematologica. 2018;103:1018–1028.
   PubMed Web of Science ®Google Scholar
• Miyake T, Yamamoto T, Hirai Y, et al. Survival rates and prognostic factors of Epstein-Barr virus-associated hydroa vacciniforme and hypersensitivity to mosquito bites. Br J Dermatol. 2015;172:56–63.
   PubMed Web of Science ®Google Scholar
• Hirai Y, Yamamoto T, Kimura H, et al. Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ cells. J Invest Dermatol. 2012;132:1401–1408.
   PubMed Web of Science ®Google Scholar
• Iwatsuki K, Miyake T, Hirai Y, et al. Hydroa vacciniforme: a distinctive form of Epstein-Barr virus-associated T-cell lymphoproliferative disorders. Eur J Dermatol. 2019;29:21–28.
   PubMed Web of Science ®Google Scholar
• Laurini JA, Perry AM, Boilesen E, et al. Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases. Blood. 2012;120:4795–4801.
   PubMed Web of Science ®Google Scholar
• Aviles A. Nasal NK/T-cell lymphoma. A comparative analysis of a Mexican Population with the other populations of Latin America. Mediterr J Hematol Infect Dis. 2015;7:e2015052.
   PubMed Web of Science ®Google Scholar
• Vose J, Armitage J, Weisenburger D; International T-Cell Lymphoma Project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124–4130.
   PubMed Web of Science ®Google Scholar
• Quintanilla-Martinez L, Kremer M, Keller G, et al. P53 mutations in nasal natural Killer/T-cell lymphoma from Mexico. Association with large cell morphology and advanced disease. Am J Pathol. 2001; 159:2095–2105.
   PubMed Web of Science ®Google Scholar
• Su IJ, Chen RL, Lin DT, et al. Epstein-Barr virus (EBV) infects T lymphocytes in childhood EBV-associated hemophagocytic syndrome in Taiwan. Am J Pathol. 1994;144:1219–1225.
   PubMed Web of Science ®Google Scholar
• Chen RL, Su IJ, Lin KH, et al. Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. An atypical form of Epstein-Barr virus infection. Am J Clin Pathol. 1991;96:171–176.
   PubMed Web of Science ®Google Scholar
• Kikuta H, Sakiyama Y, Matsumoto S, et al. Fatal Epstein-Barr virus-associated hemophagocytic syndrome. Blood. 1993;82:3259–3264.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Pinilla SM, Barrionuevo C, García J, et al. Epstein-Barr virus-positive systemic NK/T-cell lymphomas in children: report of six cases. Histopathology. 2011;59:1183–1193.
   PubMed Web of Science ®Google Scholar
• Coffey AM, Lewis A, Marcogliese AN, et al. A clinicopathologic study of the spectrum of systemic forms of EBV-associated T-cell lymphoproiferative disorders of childhood: A single tertiary care pediatric institution experience in North America. Pediatr Blood Cancer. 2019;66:e27798.
   PubMed Web of Science ®Google Scholar
• Magaña M, Massone C, Magaña P, et al. Clinicopathologic features of hydroa vacciniforme-like lymphoma: a series of 9 patients. Am J Dermatopathol. 2016;38:20–25.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Pinilla SM, Barrionuevo C, Garcia J, et al. EBV-associated cutaneous NK/T-cell lymphoma: review of a series of 14 cases from Peru in children and young adults. Am J Surg Pathol. 2010;34:1773–1782.
   PubMed Web of Science ®Google Scholar
• Sangueza M, Plaza JA. Hydroa vacciniforme-like cutaneous T-cell lymphoma: clinicopathologic and immunohistochemical study of 12 cases. J Am Acad Dermatol. 2013;69:112–119.
   PubMed Web of Science ®Google Scholar
• Plaza JA, Sangueza M. Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma. Am J Dermatopathol. 2015;37:20–25.
   PubMed Web of Science ®Google Scholar
• Ruiz-Maldonado R, Parrilla FM, Orozco-Covarrubias ML, et al. Edematous, scarring vasculitic panniculits: a new multisystemic disease with malignant potential. J Am Acad Dermatol. 1995;32:37–44.
   PubMed Web of Science ®Google Scholar
• Doeden K, Molina-Kirsch H, Perez E, et al. Hydroa-like lymphoma with CD56 expression. J Cutan Pathol. 2008;35:488–494.
   PubMed Web of Science ®Google Scholar
• Cohen JI, Jaffe ES, Dale JK, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood. 2011;117:5835–5849.
   PubMed Web of Science ®Google Scholar
• Cohen JI, Manoli I, Dowdell KC, et al. Hydroa vacciniforme-like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in whites. Blood. 2019;133:2753–2764.
   PubMed Web of Science ®Google Scholar
• Haverkos BM, Pan Z, Gru AA, et al. Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT): an update on epidemiology, clinical presentation, and natural history in North American and European cases. Curr Hematol Malig Rep. 2016;11:514–527.
   PubMed Web of Science ®Google Scholar
• Gupta G, Mohamed M, Kemmett D. Familial hydroa vacciniforme. Br J Dermatol. 1999;140:124–126.
   PubMed Web of Science ®Google Scholar
• Annamalai R. Hydroa vacciniforme in three alternate siblings. Arch Dermatol. 1971;103:224–225.
   PubMedGoogle Scholar
• Wheeler CE, Cawley EP, Whitmore CW. Hydroa aestivale in identical twins. Arch Dermatol. 1960;82:590–594.
   PubMedGoogle Scholar
• Gupta G, Man I, Kemmett D. Hydroa vacciniforme: a clinical and follow-up study of 17 cases. J Am Acad Dermatol. 2000;42:208–213.
   PubMed Web of Science ®Google Scholar
• Iwatsuki K, Xu Z, Takata M, et al. The association of latent Epstein-Barr virus infection with hydroa vacciniforme. Br J Dermatol. 1999;140:715–721.
   PubMed Web of Science ®Google Scholar
• Iwatsuki K, Satoh M, Yamamoto T, et al. Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders. Arch Dermatol. 2006;142:587–595.
   PubMedGoogle Scholar
• Cohen JI, Dropulic L, Hsu AP, et al. Association of GATA2 deficiency with severe primary Epstein-Barr virus (EBV) infection and EBV-associated cancers. Clin Infect Dis. 2016;63:41–47.
   PubMed Web of Science ®Google Scholar
• Cohen JI. GATA2 deficiency and Epstein-Barr virus disease. Front Immunol. 2017;8:1869.
   PubMed Web of Science ®Google Scholar
• Spinner MA, Sanchez LA, Hsu AP, et al. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014;123:809–821.
   PubMed Web of Science ®Google Scholar
• Michielse CB, Bhat M, Brady A, et al. Refinement of the locus for hereditary congenital facial palsy on chromosome 3q21 in two unrelated families and screening of positional candidate genes. Eur J Hum Genet. 2006;14:1306–1312.
   PubMed Web of Science ®Google Scholar
• Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, et al. De novo mutations in PLXND1 and REV3L cause Mobius syndrome. Nat Commun. 2015;6:7199.
   PubMed Web of Science ®Google Scholar
• Kimura H. EBV in T-/NK-Cell tumorigenesis. Adv Exp Med Biol. 2018;1045:459–475.
   PubMed Web of Science ®Google Scholar
• Okuno Y, Murata T, Sato Y, et al. Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Nat Microbiol. 2019;4:404–413.
   PubMed Web of Science ®Google Scholar
• Klinke O, Feederle R, Delecluse HJ, et al. Genetics of Epstein-Barr virus microRNAs. Semin Cancer Biol. 2014;26:52–59.
   PubMed Web of Science ®Google Scholar
• Lin X, Tsai MH, Shumilov A, et al. The Epstein-Barr virus BART miRNA cluster of the M81 strain modulates multiple functions in primary B cells. PLoS Pathog. 2015;11:e1005344.
   PubMed Web of Science ®Google Scholar