1,271
Views
8
CrossRef citations to date
0
Altmetric
Letters to the Editor

Use of allopurinol to reduce hepatotoxicity from 6-mercaptopurine (6-MP) in patients with acute lymphoblastic leukemia (ALL)

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1246-1249 | Received 02 Sep 2019, Accepted 29 Nov 2019, Published online: 16 Dec 2019

References

  • Schmiegelow K, Nielsen SN, Frandsen TL, et al. Mercaptopurine/methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction. J Pediatr Hematol Oncol. 2014;36(7):503–517.
  • Zaza G, Cheok M, Krynetskaia N, et al. Thiopurine pathway. Pharmacogenet Genom. 2010;20(9):573.
  • Bhatia S, Landier W, Shangguan M, et al. Nonadherence to oral mercaptopurine and risk of relapse in hispanic and non-hispanic white children with acute lymphoblastic leukemia: a report from the children’s oncology group. J Clin Oncol . 2012;30(17):2094–2101.
  • Gerich ME, Quiros JA, Marcin JP, et al. A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine. J Crohns Colitis. 2010;4(5):546–552.
  • Hoentjen F, Seinen ML, Hanauer SB, et al. Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(2):363–369.
  • Leung Y, Sparrow MP, Schwartz M, et al. Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease. J Crohns Colitis. 2009;3(3):162–167.
  • Brackett J, Schafer ES, Bernhardt MB. Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism. Pediatr Blood Cancer. 2013; 10:1–4.
  • Giamanco NM, Cunningham BS, Klein LS, et al. Allopurinol use during maintenance therapy for acute lymphoblastic leukemia avoids mercaptopurine-related hepatotoxicity. J Pediatr Hematol Oncol. 2016;38(2):147–151.
  • Angiolillo A, Schore R, Devidas M, et al. Intensification of oral methotrexate is not superior to standard methotrexate dosing during maintenance in children with National Cancer Institute (NCI) Standard-Risk B Acute Lymphoblastic Leukemia (SR B-ALL): a report from Children’s Oncology Group (COG) study AALL0932. Blood. 2017; 130:140.
  • Salzer WL, Burke MJ, Devidas M, et al. Triple intrathecal therapy (Methotrexate/Hydrocortisone/Cytarabine) does not improve disease-free survival versus intrathecal methotrexate alone in children with high risk b-lymphoblastic leukemia: results of children’s oncology group study AALL1131. Blood. 2018;132(Supplement 1):35.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.