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Letters to the Editor

Severe chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants

ORCID Icon, , , , , , , , & show all
Pages 1257-1259 | Received 05 Nov 2019, Accepted 24 Dec 2019, Published online: 16 Jan 2020

References

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  • Ciccia A, Ling C, Coulthard R, et al. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell. 2007;25(3):331–343.
  • Deans AJ, West SC. FANCM connects the genome instability disorders Bloom’s Syndrome and Fanconi anemia. Mol Cell. 2009;36(6):943–953.
  • Bogliolo M, Bluteau D, Lespinasse J, et al. Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia. Genet Med. 2018;20(4):458–463.
  • Catucci I, Osorio A, Arver B, et al. Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility. Genet Med. 2018;20(4):452–457.
  • Peterlongo P, GENESIS, Catucci I, Colombo M, et al. FANCM c.5791C > T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor. Hum Mol Genet. 2015;24(18):5345–5355.
  • Neidhardt G, Hauke J, Ramser J, et al. Association between loss-of-function mutations within the FANCM gene and early-onset familial breast cancer. JAMA Oncol. 2017;3(9):1245–1248.
  • Figlioli G, Bogliolo M, Catucci I, et al. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer. NPJ Breast Cancer. 2019;5(1):38.
  • Kiiski JI, Pelttari LM, Khan S, et al. Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer. Proc Natl Acad Sci USA. 2014;111(42):15172–15177.

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