Advanced search
Publication Cover
Leukemia & Lymphoma Volume 61, 2020 - Issue 6
Submit an article Journal homepage
427
Views
7
CrossRef citations to date
0
Altmetric
Letters to the Editor

Modified CLL International Prognostic Index (CLL-LIPI) using lymphocyte doubling time (LDT) in place of IgHV mutation status in resource-limited settings predicts time to first treatment and overall survival

Deepesh P. LadDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3754-7774
ORCID Icon,
V. TejaswiDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Nishant JindalDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Pankaj MalhotraDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Alka KhadwalDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Gaurav PrakashDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Arihant JainDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
,
Sreejesh SreedharanunniDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Manupdesh Singh SachdevaDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Shano NaseemDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Neelam VarmaDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
&
Subhash VarmaDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
show all
Pages 1512-1515 | Received 22 Oct 2019, Accepted 09 Jan 2020, Published online: 29 Jan 2020

References

  • International CLL-IPI working group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data. Lancet Oncol. 2016;17(6):779–790.
  • da Cunha-Bang C, Christiansen I, Niemann CU. The CLL-IPI applied in a population-based cohort. Blood. 2016;128(17):2181–2183.
  • Mato A, Nabhan C, Kay NE, et al. Real-world clinical experience in the Connect. Br J Haematol. 2016;175(5):892–903.
  • Mato A, Nabhan C, Kay NE, et al. Prognostic testing patterns and outcomes of chronic lymphocytic leukemia patients stratified by fluorescence in situ hybridization/cytogenetics: a real-world clinical experience in the connect CLL registry. Clin Lymphoma Myeloma Leuk. 2018;18(2):114–124.e2.
  • Mato AR, Barrientos JC, Brander D, et al. Prognostic testing and treatment approaches based on real-world clinical experience from an interim analysis of the informcll registry of patients with chronic lymphocytic leukemia: pf383. HemaSphere. 2019;3:143–144.
  • Delgado J, Baumann T, Mozas P, et al. CLL: is lymphocyte doubling time (LDT) a relevant prognostic parameter in the era of prognostic biomarkers? EHA Library. 2017;180807:E1031.
  • Rozovski U, Keating MJ, Estrov Z. Why is the immunoglobulin heavy chain gene mutation status a prognostic indicator in chronic lymphocytic leukemia? Acta Haematol. 2018;140(1):51–54.
  • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia. Blood. 2018;131(25):2745–2760.
  • Wierda WG, O’Brien S, Wang X, et al. Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia. Blood. 2007;109(11):4679–4685.
  • Wierda WG, O’Brien S, Wang X, et al. Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia. J Clin Oncol. 2011;29(31):4088–4095.
  • Pflug N, Bahlo J, Shanafelt TD, et al. Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia. Blood. 2014;124(1):49–62.
  • Gentile M, Shanafelt TD, Cutrona G, et al. A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients. Leukemia. 2016;30(6):1440–1443.
  • Parikh SA, Strati P, Tsang M, et al. Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis. Blood. 2016;127(14):1752–1760.
  • Montserrat E, Sanchez-Bisono J, Viñolas N, et al. Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance. Br J Haematol. 1986;62(3):567–575.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.