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Leukemia & Lymphoma Volume 61, 2020 - Issue 8
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Letters to the Editor

Significance of isolated deletion (20q) in donor cells after allogeneic hematopoietic cell transplantation

Sunita NathanDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Sushma BharadwajDivision of Hematology and Oncology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA;
,
Kristy LukeDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Laura KalasDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Deborah A. KatzDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Mohammad Junaid HussainDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Ira MillerDepartment of Pathology, Rush University Medical Center, Chicago, IL, USA
,
Wei-Tong HsuDepartment of Pathology, Rush University Medical Center, Chicago, IL, USA
,
Jamile ShammoDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
,
Parameswaran VenugopalDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA;
&
Celalettin UstunDivision of Hematology, Oncology and Cellular Therapy, Rush University Medical Center, Chicago, IL, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6896-6213
ORCID Icon show all
Pages 2008-2011 | Received 10 Dec 2019, Accepted 20 Mar 2020, Published online: 19 Apr 2020

References

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  • Hasserjian RP, Dal Cin P. Deletion of chromosome 20q: friend or foe? Leuk Res. 2011;35(7):844–845.
  • Huh J, Tiu RV, Gondek LP, et al. Characterization of chromosome arm 20q abnormalities in myeloid malignancies using genome-wide single nucleotide polymorphism array analysis. Genes Chromosom Cancer. 2010;49(4):NA–N9.
  • Aimakopoulos FA, Green AR. Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders. Br J Haematol. 1996;95(2):219–226.
  • Matsuda A, Jinnai I, Yagasaki F, et al. The pathogenetic mechanism of myeloid malignancies associated with deletions of the long arm of chromosome 20 can not be explained by a “one hit” model. An acute myeloid leukemia patient who developed with 20q- clone during complete remission for 9 years. Eur J Haematol. 2000;65(3):210–211.
  • Aikawa V, Porter D, Luskin MR, et al. Transmission of an expanding donor-derived del(20q) clone through allogeneic hematopoietic stem cell transplantation without the development of a hematologic neoplasm. Cancer Genet. 2015;208(12):625–629.
  • Kanagal-Shamanna R, Yin CC, Miranda RN, et al. Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q). Cancer Genet. 2013;206(1–2):42–46.
  • Mielcarek M, Bryant E, Loken M, et al. Long-term engraftment and clonal dominance of donor-derived del(20q) hematopoietic cells after allogeneic stem cell transplantation. Blood. 2006;107(4):1732–1733.
  • Yoon J, Yun JW, Jung CW, et al. Clonal dominance of a donor-derived del(20q) clone after allogeneic hematopoietic stem cell transplantation in an acute myeloid leukemia patient with del(20q). J Clin Lab Anal. 2019;33(7):e22951.
  • Sala Torra O, Loeb KR. Donor cell-derived leukemia and myelodysplastic neoplasm: unique forms of leukemia. Am J Clin Pathol. 2011;135(4):501–504.
  • Nishihori T, El-Asmar J, Shah B, et al. Donor-derived constitutional chromosomal abnormalities after allogeneic hematopoietic cell transplantation: a single-center experience and a review of the literature. Bone Marrow Transplant. 2015;50(10):1388–1392.

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