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Leukemia & Lymphoma Volume 61, 2020 - Issue 9
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Letters to the Editor

Isolated trisomy 11 in patients with acute myeloid leukemia – is the prognosis not as grim as previously thought?*

Jan Philipp BewersdorfDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ORCID Iconhttp://orcid.org/0000-0003-3352-0902View further author information
ORCID Icon,
Rory M. ShallisDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ORCID Iconhttp://orcid.org/0000-0002-8542-2944View further author information
ORCID Icon,
Autumn DiadamoDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA; View further author information
,
Lohith GowdaDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Nikolai A. PodoltsevDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Alexa SiddonDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; ;Department of Pathology, Section of Hematopathology, Yale School of Medicine, New Haven, CT, USA; View further author information
&
Amer M. ZeidanDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ;Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT, USACorrespondence[email protected]
View further author information
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Pages 2254-2257 | Received 17 Jan 2020, Accepted 06 Apr 2020, Published online: 26 Apr 2020

References

  • Eisfeld AK, Kohlschmidt J, Mrózek K, et al. Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2. Leukemia. 2016;30(11):2254–2258.
  • Wang SA, Jabbar K, Lu G, et al. Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features. Leukemia. 2010;24(4):740–747.
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  • Dinardo CD, Stein AS, Stein EM, et al. Mutant IDH (mIDH) inhibitors, ivosidenib or enasidenib, with azacitidine (AZA) in patients with acute myeloid leukemia (AML). J Clin Oncol. 2018;36(15_suppl):7042.
  • Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209–2221.
  • Bewersdorf JP, Stahl M, Zeidan AM. Are we witnessing the start of a therapeutic revolution in acute myeloid leukemia? Leuk Lymphoma. 2019;60(6):1354–1369.
  • Herold T, Metzeler KH, Vosberg S, et al. Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis. Blood. 2014;124(8):1304–1311.
  • Slovak ML, Traweek ST, Willman CL, et al. Trisomy 11: an association with stem/progenitor cell immunophenotype. Br J Haematol. 1995;90(2):266–273.

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