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Original Articles

Ponatinib-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the real-life OPAL study

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Pages 2161-2167 | Received 15 Jan 2020, Accepted 24 Apr 2020, Published online: 08 Jun 2020

References

  • Ravandi F. How I treat Philadelphia chromosome-positive acutelymphoblastic leukemia. Blood. 2019;133(2):130–136.
  • Quintás-Cardama A, Cortes J. Therapeutic options against BCR-ABL1 T315I-positive chronic myelogenous leukemia. Clin Cancer Res. 2008;14(14):4392–4399.
  • United States Food and Drug Administration FDA Drug Safety Communication. FDA asks manufacturer of the leukemia drug Iclusig (ponatinib) to suspend marketing and sales; [cited 2014 June 17]. Available from: http://www.fda.gov/drugs/drugsafety/ucm373040.htm
  • Abou Dalle I, Kantarjian HM, Short NJ, et al. Ph + ALL in first relapse in the era of TKI inhibitors. Am J Hematol. 2019;94(12):1388–1395.
  • Cortes JE, Kim DW, Pinilla-Ibarz J, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013;369(19):1783–1796.
  • Heiblig M, Rea D, Chrétien ML, et al. Ponatinib evaluation and safety in real-life chronic myelogenous leukemia patients failing more than two tyrosine kinase inhibitors: the PEARL observational study. Exp Hematol. 2018; 67:41–48.
  • Breccia M, Abruzzese E, Castagnetti F, et al. Ponatinib as second-line treatment in chronic phase chronic myeloid leukemia patients in real-life practice. Ann Hematol. 2018;97(9):1577–1580.
  • Couturier MA, Thomas X, Huguet F, et al. Blinatumomab + ponatinib for relapsed Ph1-positive acute lymphoblastic leukemia: the French experience. EHA E-Poster Couturier M. 2019;267247:PS946.
  • Müller MC, Cross NC, Erben P, et al. Harmonization of molecular monitoring of CML therapy in. Eur Leukemia. 2009;23(11):1957–1963.
  • Soverini S, Hochhaus A, Nicolini FE, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood. 2011;118(5):1208–1215.
  • Stemhagen A, Adib D, Lustgarten S, et al. The OMNI Patient Registry: a prospective, observational, non-interventional registry to evaluate vascular safety of ponatinib treatment in patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). Clin Lymphoma Myeloma Leuk. 2017;17:S309–S310.
  • Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood. 2006;108(1):28–37.
  • Clappier E, Rathana K, Cayuela JM, et al. Persistent BCR-ABL1 clonal hematopoiesis after blast clearance identifies a CML-like subgroup of patients with Philadelphia chromosome-positive (Ph+) ALL: interim results from the GRAAPH-2014 trial. EHA E-Poster Couturier M. 2018;214483:S1568.
  • Ravandi F, Jorgensen J, Thomas DA, et al. Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy. Blood. 2013;122(7):1214–1221.
  • Hoelzer D, Bassan R, Dombret H, et al. Acute lymphoblastic leukaemia in adult patients: ESM0 Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27:v69–v82.
  • Tachibana T, Koyama S, Taiki Andou T, et al. Salvage and bridging to allogeneic hematopoietic cell transplantation with ponatinib in patients with relapsed or refractory Philadelphia chromosome-positive leukemia. Int J Hematol. 2019;109(2):162–168.
  • Mauro M, Lisa J, McGarry LJ, Mo Yang M, et al. Characteristics of ponatinib therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph + all) patients in real-world clinical practice compared to the PACE trial. EHA E-Poster Couturier M. 2016;132657:E1108.
  • Lilly MB, Ottmann OG, Shah NP, et al. Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: results from a phase 3 study. Am J Hematol. 2010;85(3):164–170.
  • Benjamini O, Dumlao TL, Kantarjian H, et al. Phase II trial of hyperCVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia. Am J Hematol. 2014;89(3):282–287.
  • Ottmann OG, Larson RA, Kantarjian HM, et al. Phase II study of nilotinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia. 2013;27(6):1411–1413.
  • Gambacorti‐Passerini C, Kantarjian HM, Kim DW, et al. Long‐term efficacy and safety of bosutinib in patients with advanced leukemia following resistance/intolerance to imatinib and other tyrosine kinase inhibitors. Medicine (Baltimore). 2016; 90(9): 755–768.
  • Rousselot P, Coudé MM, Gokbuget N, et al. Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL. Blood. 2016;128(6):774–782.
  • Jabbour E, Kantarjian H, Ravandi F, et al. Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: a single-centre, phase 2 study. Lancet Oncol. 2015;16(15):1547–1555.
  • Jabbour E, Short NJ, Ravandi F, et al. Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: long-term follow-up of a single-centre, phase 2 study. Lancet Haematol. 2018;5(12):e618–e627.
  • Martinelli G, Piciocchi A, Papayannidis C, et al. First report of the Gimema LAL1811 phase II prospective study of the combination of steroids with ponatinib as frontline therapy of elderly or unfit patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2017;130:99–99.
  • Short NJ, Kantarjian H, Pui CH, et al. SOHO state of the art update and next questions: Philadelphia chromosome-positive acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk. 2018;18(7):439–446.
  • Martinelli G, Boissel N, Chevallier P, et al. Complete hematologic and molecular response in adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukaemia following treatment with blinatumomab: results from a phase II, single-arm, multicenter study. JCO. 2017;35(16):1795–1802.
  • Kantarjian HM, DeAngelo DJ, Stelljes M, et al. inotuzumab ozogamicin versus standard therapy for acute lymphoblastic leukaemia. N Engl J Med. 2016;375(8):740–753.
  • Assi R, Kantarjian H, Short NJ, et al. Safety and efficacy of blinatumomab in combination with a tyrosine kinase inhibitor for the treatment of relapsed Philadelphia chromosome-positive leukemia. Clin Lymphoma Myeloma Leuk. 2017;17(12):897–901.
  • King AC, Pappacena JJ, Tallman MS, et al. Blinatumomab administered concurrently with oral tyrosine kinase inhibitor therapy is a well-tolerated consolidation strategy and eradicates measurable residual disease in adults with Philadelphia chromosome positive acute lymphoblastic leukemia. Leuk Res. 2019; 79:27–33.
  • El Chaer F, Holtzman NG, Sausville EA, et al. Relapsed Philadelphia chromosome-positive pre-B-ALL after CD19-directed CAR-T Cell therapy successfully treated with combination of blinatumomab and ponatinib. Acta Haematol. 2019;141(2):107–110.
  • Zhu YM, Wu Z, Tan YP, et al. Anti-CD19 chimeric antigen receptor T-cell therapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia: two case reports. Medicine (Baltimore). 2016;95(51):e5676.
  • Comoli P, Basso S, Riva G, et al. BCR-ABL-specific T-cell therapy in Ph + ALL patients on tyrosine-kinase inhibitors. Blood. 2017;129(5):582–586.

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