Advanced search
Publication Cover
Leukemia & Lymphoma Volume 61, 2020 - Issue 10
Submit an article Journal homepage
176
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Autologous stem cell transplantation in multiple myeloma patients: utilization patterns and hospital effects

Lina JansenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; View further author information
,
Maximilian MerzMedizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany; Correspondence[email protected]
View further author information
,
Monika EngelhardtUniversitätsklinikum Freiburg, Freiburg, Germany; View further author information
,
Katja WeiselII. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; View further author information
,
Christof ScheidUniversitätsklinikum Köln, Köln, Germany; View further author information
,
Christian StrakaMünchen Klinik Schwabingen, München, Germany; View further author information
,
Christian LangerKlinikum Kempten, Kempten, Germany; View further author information
,
Hans SalwenderAsklepios Kliniken Altona und St. Georg, Hamburg, Germany; View further author information
,
Hermann EinseleUniversitätsklinikum Würzburg, Würzburg, Germany; View further author information
,
Nikolaus KrögerInterdisziplinäre Klinik für Stammzelltransplantation, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; View further author information
,
Dietrich W. BeelenKlinik für Knochenmarktransplantation des Universitätsklinikums Essen, Essen, Germany; View further author information
,
Peter DregerMedizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany; View further author information
,
Hartmut GoldschmidtMedizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany; ;National Center for Tumor Diseases (NCT), Heidelberg, Germany; ORCID Iconhttp://orcid.org/0000-0003-0961-0035View further author information
ORCID Icon,
Hermann BrennerMedizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany; ;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; ;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, GermanyORCID Iconhttp://orcid.org/0000-0002-6129-1572View further author information
ORCID Icon & the German National Registry for Stem Cell Transplants (DRST) show all
Pages 2365-2374 | Received 14 Feb 2020, Accepted 05 May 2020, Published online: 30 May 2020

References

  • Rollig C, Knop S, Bornhauser M. Multiple myeloma. Lancet. 2015;385(9983):2197–2208.
  • Benboubker L, Dimopoulos MA, Dispenzieri A, et al. Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N Engl J Med. 2014;371(10):906–917.
  • Rosenberg AS, Brunson A, Jonas BA, et al. Association Between Autologous Stem Cell Transplant and Survival Among Californians With Multiple Myeloma. J Natl Cancer Inst. 2019;111(1):78–85.
  • Auner HW, Szydlo R, Hoek J, et al. Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe: increased use and improved outcomes in elderly patients in recent years. Bone Marrow Transplant. 2015;50(2):209–215.
  • Birkmeyer JD, Siewers AE, Finlayson EV, et al. Hospital volume and surgical mortality in the United States. N Engl J Med. 2002;346(15):1128–1137.
  • Gratwohl A, Sureda A, Baldomero H, et al. Economics and outcome after hematopoietic stem cell transplantation: a retrospective cohort study. EBioMedicine. 2015;2(12):2101–2109.
  • Loberiza FR, Jr., Zhang MJ, Lee SJ, et al. Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States. Blood. 2005;105(7):2979–2987.
  • Go RS, Bottner WA, Gertz MA. Making the case to study the volume-outcome relationship in hematologic cancers. Mayo Clin Proc. 2015;90(10):1393–1399.
  • Ailawadhi S, Bhatia K, Aulakh S, et al. Equal treatment and outcomes for everyone with multiple myeloma: are we there yet?. Curr Hematol Malig Rep. 2017;12(4):309–316.
  • Go RS, Bartley AC, Crowson CS, et al. Association between treatment facility volume and mortality of patients with multiple myeloma. JCO. 2017;35(6):598–604.
  • Liu Y, Han H, Shah G, et al. Significant nationwide variability in the costs and hospital mortality rates of autologous stem cell transplantation for multiple myeloma: an analysis of the nationwide inpatient sample database. Biol Blood Marrow Transplant. 2019;25(1):41–46.
  • Blimark CH, Turesson I, Genell A, et al. Outcome and survival of myeloma patients diagnosed 2008-2015. Real-world data on 4904 patients from the Swedish Myeloma Registry. Haematologica. 2018;103(3):506–513.
  • Robert Koch Institute. German Centre for Cancer Registry Data, Database Query. [cited 2018 May 2]. Available from: http://www.krebsdaten.de/database
  • Jansen L, Castro FA, Gondos A, et al. Recent cancer survival in Germany: an analysis of common and less common cancers. Int J Cancer. 2015;136(11):2649–2658.
  • Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996;17(4):343–346.
  • Zhang X, Loberiza FR, Klein JP, et al. A SAS macro for estimation of direct adjusted survival curves based on a stratified Cox regression model. Comput Methods Programs Biomed. 2007;88(2):95–101.
  • van Buuren S, Groothuis-Oudshoorn K. Mice: multivariate imputation by chained equations in R. J Stat Soft. 2011;45(3):1–67.
  • Sauerbrei W, Meier-Hirmer C, Benner A, et al. Multivariable regression model building by using fractional polynomials: description of SAS, STATA and R programs. Comput Stat Data Anal . 2006;50:3454–3485.
  • Schriber JR, Hari PN, Ahn KW, et al. Hispanics have the lowest stem cell transplant utilization rate for autologous hematopoietic cell transplantation for multiple myeloma in the United States: a CIBMTR report. Cancer. 2017;123(16):3141–3149.
  • Al-Hamadani M, Hashmi SK, Go RS. Use of autologous hematopoietic cell transplantation as initial therapy in multiple myeloma and the impact of socio-geo-demographic factors in the era of novel agents. Am J Hematol. 2014;89(8):825–830.
  • Merz M, Jansen L, Castro FA, et al. Survival of elderly patients with multiple myeloma-Effect of upfront autologous stem cell transplantation. Eur J Cancer. 2016;62:1–8.
  • Garderet L, Beohou E, Caillot D, et al. Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study. Haematologica. 2016;101(11):1390–1397.
  • Winn AN, Shah GL, Cohen JT, et al. The real world effectiveness of hematopoietic transplant among elderly individuals with multiple myeloma. J Natl Cancer Inst. 2015;107(8):djv139.
  • Majhail NS, Mau LW, Chitphakdithai P, et al. Transplant center characteristics and survival after allogeneic hematopoietic cell transplantation in adults. Bone Marrow Transplant. 2020;55(5):906–917.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.