Advanced search
Publication Cover
Leukemia & Lymphoma Volume 61, 2020 - Issue 14
Submit an article Journal homepage
126
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance

Sara Mohameda Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Roberto Latagliataa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Maria Zaira Limongia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Stefania Nigroa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Eleonora Sangiorgia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Mauro Nannia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Annalina Piccionib Hematology, Azienda Ospedaliera S. Giovanni-Addolorata, Rome, Italy
,
Alessia Campagnac Hematology, Sant’Andrea Hospital Sapienza University of Rome, Rome, Italy
,
Maria Antonietta Aloe Spiritic Hematology, Sant’Andrea Hospital Sapienza University of Rome, Rome, Italy
,
Ida Carmosinoa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Matteo Molicaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Elena Mariggiòa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Serena Rosatia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Gioia Colafiglia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Francesca Fazioa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Maria Lucia De Lucaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Daniela De Benedittisa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Emilia Scalzullia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
,
Massimo Brecciaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy
&
Marco Mancinia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]
 show all
Pages 3476-3483 | Received 03 Apr 2020, Accepted 13 Aug 2020, Published online: 01 Sep 2020

References

  • Valent P, Orazi A, Steensma DP, et al. Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions. Oncotarget. 2017;8(43):73483–73500.
  • Costa D, Muñoz C, Carrió A, et al. Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: review of 5,654 patients with an evaluable karyotype. Genes Chromosomes Cancer. 2013;52(8):753–763.
  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–2405.
  • Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454–2465.
  • Montalban-Bravo G, Garcia-Manero G. Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 2018;93(1):129–147.
  • ISCN 2016: An international system for human cytogenomic nomenclature. Basel: Karger; 2016.
  • Schanz J, Tüchler H, Solé F, et al. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol. 2012;30(8):820–829.
  • Breems DA, Van Putten WL, De Greef GE, et al. Monosomal Karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008;26(29):4791–4797.
  • Nomdedeu M, Calvo X, Pereira A, et al. Prognostic impact of chromosomal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemia patients. A study by the spanish group of myelodysplastic syndromes. Genes Chromosomes Cancer. 2016;55(4):322–327.
  • Walker A, Mrózek K, Kohlschmidt J, et al. New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461. Genes Chromosomes Cancer. 2013;52(4):385–401.
  • Ai J, Visconte V, Tabarroki A, et al. Non-t(6;9) and Non-Inv(3) balanced chromosomal rearrangements are associated with poor survival outcomes in myelodysplastic syndromes. Clin Lymphoma Myeloma Leuk. 2015;15(8):489–495.
  • Bacher U, Schanz J, Braulke F, et al. Rare cytogenetic abnormalities in myelodysplastic syndromes. Mediterr J Hematol Infect Dis. 2015;7(1):e2015034.
  • Patnaik MM, Hanson CA, Hodnefield JM, et al. Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically worse than an otherwise complex karyotype. Leukemia. 2011;25(2):266–270.
  • Xing R, Li C, Gale RP, et al. Monosomal karyotype is an independent predictor of survival in patients with higher risk myelodysplastic syndrome. Am J Hematol. 2014;89(10):e163–e168.
  • Gangat N, Patnaik MM, Begna K, et al. Evaluation of revised IPSS cytogenetic risk stratification and prognostic impact of monosomal karyotype in 783 patients with primary myelodysplastic syndromes. Am J Hematol. 2013;88(8):690–693.
  • Wang N, Xu H, Li Q, et al. Monosomal karyotypes apart from complex karyotypes independently predict the outcome of myelodysplastic syndrome patients using a fluorescence in situ hybridization panel and conventional cytogenetics. Int J Lab Hematol. 2019;41(4):519–529.
  • Valcarcel D, Adema V, Sole F, et al. Complex, not monosomal, karyotype is the cytogenetic marker of poorest prognosis in patients with primary myelodysplastic syndrome. J Clin Oncol. 2013;31(7):916–922.
  • Schanz J, Tuchler H, Sole F, et al. Monosomal karyotype in MDS: explaining the poor prognosis? Leukemia. 2013;27(10):1988–1995.
  • Wu YC, Zhang XM, Zhu YD, et al. Prognostic significance of monosomal karyotype in myelodysplastic syndrome: a meta-analysis. Hematology. 2019;24(1):60–69.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.