Advanced search
Publication Cover
Leukemia & Lymphoma Volume 63, 2022 - Issue 5
Submit an article Journal homepage
216
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Prognostic impact of micromegakaryocytes in primary myelodysplastic syndromes

Sílvia Saumella Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, SpainCorrespondence[email protected]
,
Miranda Fernández-Serranob Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain;c Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
,
Alba Mesaa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Félix López-Cadenasd Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
,
Leonor Arenillase Laboratory of Cytology, Department of Pathology, GRETNHE, IMIM Hospital del Mar Research Institute, Barcelona, Spain
,
Ana Alfonsof Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain
,
Maria Julia Montoroa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Antonieta Moleroa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Pilar Leozd Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
,
Victoria Riegof Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain
,
Laura Gallura Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Olga Salameroa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, SpainORCID Iconhttps://orcid.org/0000-0003-3237-0025
ORCID Icon,
Mayda Navarretea Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Bárbara Tazón-Vegaa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Margarita Ortegaa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
,
Òscar Reigg Medical Oncology Department, Hospital Clínic, Translational Genomics and Targeted Therapeutics in Solid Tumors Group (IDIBAPS), Barcelona, Spain
,
Gaël Rouéa Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain;c Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
,
Xavier Calvoe Laboratory of Cytology, Department of Pathology, GRETNHE, IMIM Hospital del Mar Research Institute, Barcelona, Spain
,
Felipe Prosperf Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, SpainORCID Iconhttps://orcid.org/0000-0001-6115-8790
ORCID Icon,
María Díez-Campelod Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
&
David Valcárcela Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
 show all
Pages 1227-1235 | Received 11 Sep 2021, Accepted 06 Dec 2021, Published online: 31 Dec 2021

References

  • Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon (France): IARC Press; 2017.
  • Cazzola M. Myelodysplastic syndromes. N Engl J Med. 2020;383(14):1358–1374.
  • Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454–2465.
  • Malcovati L, Hellström-Lindberg E, Bowen D, et al. Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood. 2013;122(17):2943–2964.
  • Kuriyama K, Tomonaga M, Matsuo T, et al. Diagnostic significance of detecting pseudo-Pelger-Huët anomalies and micro-megakaryocytes in myelodysplastic syndrome. Br J Haematol. 1986;63(4):665–669.
  • Matsuda A, Germing U, Jinnai I, et al. Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification. Leukemia. 2007;21(4):678–686.
  • Feng G, Gale RP, Cui W, et al. A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes. Exp Hematol Oncol. 2015;5(1):12.
  • Weinberg OK, Gibson CJ, Blonquist TM, et al. Association of mutations with morphological dysplasia in de novo acute myeloid leukemia without 2016 WHO classification-defined cytogenetic abnormalities. Haematologica. 2018;103(4):626–633.
  • Goasguen JE, Bennett JM, Bain BJ, et al. Quality control initiative on the evaluation of the dysmegakaryopoiesis in myeloid neoplasms: difficulties in the assessment of dysplasia. Leuk Res. 2016;45:75–81.
  • Florensa L, Arenillas L, Calvo X, et al. The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes. Histol Histopathol. 2019;34(8):857–873.
  • Senent L, Arenillas L, Luño E, et al. Reproducibility of the world health organization 2008 criteria for myelodysplastic syndromes. Haematologica. 2013;98(4):568–575.
  • Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155–163.
  • Schanz J, Tüchler H, Solé F, et al. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol. 2012;30(8):820–829.
  • Della Porta MG, Tuechler H, Malcovati L, et al. Validation of WHO classification-based prognostic scoring system (WPSS) for myelodysplastic syndromes and comparison with the revised international prognostic scoring system (IPSS-R). a study of the international working group for prognosis in Myelodysplasia (IWG-PM). Leukemia. 2015;29(7):1502–1513.
  • Germing U, Strupp C, Giagounidis A, et al. Evaluation of dysplasia through detailed cytomorphology in 3156 patients from the Düsseldorf Registry on myelodysplastic syndromes. Leuk Res. 2012;36(6):727–734.
  • Mattia G, Vulcano F, Milazzo L, et al. Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood. 2002;99(3):888–897.
  • Mazzi S, Lordier L, Debili N, et al. Megakaryocyte and polyploidization. Exp Hematol. 2018;57:1–13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.