Evaluation of central line salvage for mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) management practices in patients with hematologic malignancies

References

• Klastersky J, Ameye L, Maertens J, et al. Bacteraemia in febrile neutropenic cancer patients. Int J Antimicrob Agents. 2007;30(Suppl 1):51–59.
   PubMed Web of Science ®Google Scholar
• Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2011;52(4):e56–e93.
   PubMed Web of Science ®Google Scholar
• Gustinetti G, Mikulska M. Bloodstream infections in neutropenic cancer patients: a practical update. Virulence. 2016;7(3):280–297.
   PubMed Web of Science ®Google Scholar
• Dandoy CE, Kim S, Chen M, et al. Incidence, risk factors, and outcomes of patients who develop mucosal barrier injury-laboratory confirmed bloodstream infections in the first 100 days after allogeneic hematopoietic stem cell transplant. JAMA Netw Open. 2020;3(1):e1918668.
   PubMed Web of Science ®Google Scholar
• Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-central Line Associated Bloodstream Infection) https://www.cdc.gov/nhsn/pdfs/pscmanual/4psc_clabscurrent.pdf.
   Google Scholar
• See I, Iwamoto M, Allen-Bridson K, et al. Mucosal barrier injury laboratory-confirmed bloodstream infection: results from a field test of a new national healthcare safety network definition. Infect Control Hosp Epidemiol. 2013;34(8):769–776.
   PubMed Web of Science ®Google Scholar
• See I, Soe MM, Epstein L, et al. Impact of removing mucosal barrier injury laboratory-confirmed bloodstream infections from central line-associated bloodstream infection rates in the national healthcare safety network, 2014. Am J Infect Control. 2017;45(3):321–323.
   PubMed Web of Science ®Google Scholar
• Dandoy CE, Haslam D, Lane A, et al. Healthcare burden, risk factors, and outcomes of mucosal barrier injury laboratory-confirmed bloodstream infections after stem cell transplantation. Biol Blood Marrow Transplant. 2016;22(9):1671–1677.
   PubMed Web of Science ®Google Scholar
• Metzger KE, Rucker Y, Callaghan M, et al. The burden of mucosal barrier injury laboratory-confirmed bloodstream infection among hematology, oncology, and stem cell transplant patients. Infect Control Hosp Epidemiol. 2015;36(2):119–124.
   PubMed Web of Science ®Google Scholar
• Torres D, Gonzalez ML, Loera A, et al. The centers for disease control and prevention definition of mucosal barrier injury-associated bloodstream infection improves accurate detection of preventable bacteremia rates at a pediatric cancer center in a low- to middle-income country. Am J Infect Control. 2016;44(4):432–437.
   PubMed Web of Science ®Google Scholar
• Kato Y, Hagihara M, Kurumiya A, et al. Impact of mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) on central line-associated bloodstream infections (CLABSIs) in department of hematology at single university hospital in Japan. J Infect Chemother. 2018;24(1):31–35.
   PubMed Web of Science ®Google Scholar
• Dandoy CE, Ardura MI, Papanicolaou GA, et al. Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis. Bone Marrow Transplant. 2017;52(8):1091–1106.
   PubMed Web of Science ®Google Scholar
• Shelburne SA, Chaftari AM, Jamal M, et al. Identification and characterization of catheter-related bloodstream infections due to viridans group streptococci in patients with cancer. Am J Infect Control. 2014;42(10):1127–1129.
   PubMed Web of Science ®Google Scholar
• Hentrich M, Schalk E, Schmidt-Hieber M, et al. Central venous catheter-related infections in hematology and oncology: 2012 updated guidelines on diagnosis, management and prevention by the infectious diseases working party of the German society of hematology and medical oncology. Ann Oncol. 2014;25(5):936–947.
   PubMed Web of Science ®Google Scholar
• Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support . J Biomed Inform. 2009;42(2):377–381.
   PubMed Web of Science ®Google Scholar
• Paterson DL, Ko WC, Von Gottberg A, et al. International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial infections. Ann Intern Med. 2004;140(1):26–32.
   PubMed Web of Science ®Google Scholar
• Raad S, Chaftari AM, Hachem RY, et al. Removal and insertion of central venous catheters in cancer patients is associated with high symptom burden. Expert Rev Med Devices. 2018;15(8):591–596.
   PubMed Web of Science ®Google Scholar
• Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the infectious diseases society of America. Clin Infect Dis. 2009;49(1):1–45.
   PubMed Web of Science ®Google Scholar
• Chaftari AM, Hachem R, Raad S, et al. Unnecessary removal of central venous catheters in cancer patients with bloodstream infections. Infect Control Hosp Epidemiol. 2018;39(2):222–225.
   PubMed Web of Science ®Google Scholar
• Fares J, Khalil M, Chaftari AM, et al. Impact of catheter management on clinical outcome in adult cancer patients with gram-negative bacteremia. Open Forum Infect Dis. 2019;6(10):ofz357.
   PubMed Web of Science ®Google Scholar
• Raad I, Hanna HA, Alakech B, et al. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med. 2004;140(1):18–25.
   PubMed Web of Science ®Google Scholar
• Zakhour R, Chaftari AM, Raad II. Catheter-related infections in patients with haematological malignancies: novel preventive and therapeutic strategies. Lancet Infect Dis. 2016;16(11):e241–e250.
   PubMedGoogle Scholar
• Zanwar S, Jain P, Gokarn A, et al. Antibiotic lock therapy for salvage of tunneled central venous catheters with catheter colonization and catheter-related bloodstream infection. Transpl Infect Dis. 2019;21(1):e13017.
   PubMed Web of Science ®Google Scholar
• Tsai HC, Huang LM, Chang LY, et al. Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy. J Microbiol Immunol Infect. 2015;48(6):639–646.
   PubMedGoogle Scholar
• Wolf J, Connell TG, Allison KJ, et al. Treatment and secondary prophylaxis with ethanol lock therapy for central line-associated bloodstream infection in paediatric cancer: a randomised, double-blind, controlled trial. Lancet Infect Dis. 2018;18(8):854–863.
   PubMed Web of Science ®Google Scholar
• Wolf J, Allison KJ, Tang L, et al. No evidence of benefit from antibiotic lock therapy in pediatric oncology patients with central line-related bloodstream infection: results of a retrospective matched cohort study and review of the literature. Pediatr Blood Cancer. 2014;61(10):1811–1815.
   PubMed Web of Science ®Google Scholar
• Raad I, Chaftari AM, Zakhour R, et al. Successful salvage of central venous catheters in patients with catheter-related or central line-associated bloodstream infections by using a catheter lock solution consisting of minocycline, EDTA, and 25% ethanol. Antimicrob Agents Chemother. 2016;60(6):3426–3432.
   PubMed Web of Science ®Google Scholar
• Dandoy CE, Alonso PB. MBI-LCBI and CLABSI: more than scrubbing the line. Bone Marrow Transplant. 2019;54(12):1932–1939.
   PubMed Web of Science ®Google Scholar
• Vaughan AM, Ross R, Gilman MM, et al. Mucosal barrier injury central-line-associated bloodstream infections: what is the impact of standard prevention bundles? Infect Control Hosp Epidemiol. 2017;38(11):1385–1387. vol. 11.
   PubMed Web of Science ®Google Scholar
• Reed D, Sen J, Lassiter K, et al. Prospective initiative to reduce mucosal barrier injuries and bloodstream infections in patients with hematologic malignancy receiving inpatient chemotherapy. JCO Oncol Pract. 2020;16(3):e306–e312.
   PubMedGoogle Scholar
• Kemp G, Hallbourg M, Altounji D, et al. Back to basics: CLABSI reduction through implementation of an oral care and hygiene bundle. J Pediatr Oncol Nurs. 2019;36(5):321–326.
   PubMed Web of Science ®Google Scholar
• Giri VK, Kegerreis KG, Ren Y, et al. Chlorhexidine gluconate bathing reduces the incidence of bloodstream infections in adults undergoing inpatient hematopoietic cell transplantation. Transplant Cell Ther. 2021;27(3):262.e1–262.e11.
   Google Scholar