390
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

High-dose methotrexate dosing strategy in primary central nervous system lymphoma

ORCID Icon, , , , & ORCID Icon
Pages 1348-1355 | Received 08 Aug 2021, Accepted 28 Dec 2021, Published online: 04 Feb 2022

References

  • Grommes C, DeAngelis LM. Primary CNS lymphoma. J Clin Oncol. 2017;35(21):2410–2418.
  • Korfel A, Schlegel U. Diagnosis and treatment of primary CNS lymphoma. Nat Rev Neurol. 2013;9(6):317–327.
  • Siegal T, Bairey O. Primary CNS lymphoma in the elderly: the challenge. Acta Haematol. 2019;141(3):138–145.
  • Han S, Wang M, Liu B, et al. Pemetrexed for primary central nervous system lymphoma in the elderly. Clin Transl Oncol. 2016;18(2):138–143.
  • Graham MS, DeAngelis LM. Improving outcomes in primary CNS lymphoma. Best Pract Res Clin Haematol. 2018;31(3):262–269.
  • Ney DE, Reiner AS, Panageas KS, et al. Characteristics and outcomes of elderly patients with primary central nervous system lymphoma: the memorial Sloan–Kettering Cancer Center experience. Cancer. 2010;116(19):4605–4612.
  • Ferreri AJM. Therapy of primary CNS lymphoma: role of intensity, radiation, and novel agents. Hematology Am Soc Hematol Educ Program. 2017;2017(1):565–577.
  • O'Brien PC, Roos DE, Pratt G, Trans-Tasman Radiation Oncology Group, et al. Combined-modality therapy for primary central nervous system lymphoma: long-term data from a phase II multicenter study (Trans-Tasman radiation oncology group). Int J Radiat Oncol Biol Phys. 2006;64(2):408–413.
  • Abrey LE, DeAngelis LM, Yahalom J. Long-term survival in primary CNS lymphoma. J Clin Oncol. 1998;16(3):859–863.
  • Glass J, Gruber ML, Cher L, et al. Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome. J Neurosurg. 1994;81(2):188–195.
  • Ferreri AJ, Reni M, Foppoli M, International Extranodal Lymphoma Study Group (IELSG), et al. High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial. Lancet. 2009;374(9700):1512–1520.
  • Batchelor T, Carson K, O'Neill A, et al. Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: a report of NABTT 96-07. J Clin Oncol. 2003;21(6):1044–1049.
  • Omuro A, Chinot O, Taillandier L, et al. Hoang-Xuan K. Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial. Lancet Haematol. 2015;2(6):e251-9–e259.
  • Reni M, Ferreri AJ, Guha-Thakurta N, et al. Clinical relevance of consolidation radiotherapy and other main therapeutic issues in primary Central nervous system lymphomas treated with upfront high-dose methotrexate. Int J Radiat Oncol Biol Phys. 2001;51(2):419–425.
  • Fritsch K, Kasenda B, Hader C, et al. Immunochemotherapy with rituximab, methotrexate, procarbazine, and lomustine for primary CNS lymphoma (PCNSL) in the elderly. Ann Oncol. 2011;22(9):2080–2085.
  • Fox CP, Phillips EH, Smith J, British Society for Haematology, et al. Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma. Br J Haematol. 2019;184(3):348–363.
  • National Comprehensive Cancer Network. Central nervous system cancers (version 2.2020) [cited 2020 Aug 16]. https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf.
  • Ng S, Rosenthal MA, Ashley D, et al. High-dose methotrexate for primary CNS lymphoma in the elderly. Neuro Oncol. 2000;2(1):40–44.
  • Zhu JJ, Gerstner ER, Engler DA, et al. High-dose methotrexate for elderly patients with primary CNS lymphoma. Neuro Oncol. 2009;11(2):211–215.
  • Gaviani P, Simonetti G, Innocenti A, et al. Safety and efficacy of primary central nervous system lymphoma treatment in elderly population. Neurol Sci. 2016;37(1):131–133.
  • Chamberlain MC, Johnston SK. High-dose methotrexate and rituximab with deferred radiotherapy for newly diagnosed primary B-cell CNS lymphoma. Neuro Oncol. 2010;12(7):736–744.
  • Holdhoff M, Ambady P, Abdelaziz A, et al. High-dose methotrexate with or without rituximab in newly diagnosed primary CNS lymphoma. Neurology. 2014;83(3):235–239.
  • Ferreri AJ, Cwynarski K, Pulczynski E, International Extranodal Lymphoma Study Group (IELSG), et al. Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the international extranodal lymphoma study group-32 (IELSG32) phase 2 trial. Lancet Haematol. 2016;3(5):e217-27–e227.
  • Schorb E, Fox CP, Kasenda B, et al. Induction therapy with the MATRix regimen in patients with newly diagnosed primary diffuse large B-cell lymphoma of the central nervous system - an international study of feasibility and efficacy in routine clinical practice. Br J Haematol. 2020;189(5):879–887.
  • Bromberg JEC, Issa S, Bakunina K, et al. Rituximab in patients with primary CNS lymphoma (HOVON 105/ALLG NHL 24): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 2019;20(2):216–228.
  • Fritsch K, Kasenda B, Schorb E, et al. High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study). Leukemia. 2017;31(4):846–852.
  • Rubenstein JL, Hsi ED, Johnson JL, et al. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (alliance 50202). J Clin Oncol. 2013;31(25):3061–3068.
  • Kasenda B, Ferreri AJ, Marturano E, et al. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)-a systematic review and individual patient data meta-analysis. Ann Oncol. 2015;26(7):1305–1313.
  • Howard SC, McCormick J, Pui CH, et al. Preventing and managing toxicities of high-dose methotrexate. Oncologist. 2016;21(12):1471–1482.
  • Hoang-Xuan K, Taillandier L, Chinot O, European Organization for Research and Treatment of Cancer Brain Tumor Group, et al. Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the european organization for research and treatment of cancer brain tumor group. J Clin Oncol. 2003;21(14):2726–2731.
  • May J, Carson KR, Butler S, et al. High incidence of methotrexate associated renal toxicity in patients with lymphoma: a retrospective analysis. Leuk Lymphoma. 2014;55(6):1345–1349.
  • Ferreri AJM, Cwynarski K, Pulczynski E. MATRIX induction followed by autologous stem cell transplant or whole-brain irradiation in primary CNS lymphoma. 7-year results of the IELSG32 randomized trial. Abstract 047_16th ICML. Haemat Oncol. 2021;39(Supp 2):87–89.
  • Vu K, Mannis G, Hwang J, et al. Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma. Br J Haematol. 2019;186(1):180–183.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.