Advanced search
Publication Cover
Leukemia & Lymphoma Volume 63, 2022 - Issue 8
Submit an article Journal homepage
138
Views
0
CrossRef citations to date
0
Altmetric
Letters to the Editor

L-kynurenine as a prognostic marker for early mortality in patients with acute myeloid leukemia

Fiona Kierdorfa Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, GermanyCorrespondence[email protected]
View further author information
,
Philipp Zimmerb Division of Performance and Health (Sport Medicine), Institute for Sport and Sport Science, TU Dortmund University, Dortmund, GermanyView further author information
,
Niklas Joistenb Division of Performance and Health (Sport Medicine), Institute for Sport and Sport Science, TU Dortmund University, Dortmund, GermanyView further author information
,
David Kieslc Department of Hematology and Internal Oncology, Kepler University Linz, Linz, AustriaView further author information
,
Matteo Winkera Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, GermanyView further author information
,
Lionel Rigouxd Max-Planck-Institute for Metabolism Research, Cologne, GermanyView further author information
&
Thomas Eltere Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Köln, GermanyView further author information
 show all
Pages 2001-2004 | Received 06 Nov 2021, Accepted 08 Mar 2022, Published online: 31 Mar 2022

References

  • Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424–447.
  • Kayser S, Levis MJ. Clinical implications of molecular markers in acute myeloid leukemia. Eur J Haematol. 2019;102(1):20–35.
  • Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–1152.
  • Mandarano M, Orecchini E, Bellezza G, et al. Kynurenine/tryptophan ratio as a potential Blood-Based biomarker in Non-Small cell lung cancer. IJMS. 2021;22(9):4403.
  • Bekki S, Hashimoto S, Yamasaki K, et al. Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma. PLoS One. 2020;15(10):e0241002.
  • Wu H, Gong J, Liu Y. Indoleamine 2, 3-dioxygenase regulation of immune response (review). Mol Med Rep. 2018;17(4):4867–4873.
  • Huang A, Fuchs D, Widner B, et al. Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. Br J Cancer. 2002;86(11):1691–1696.
  • Meireson A, Devos M, Brochez L. IDO expression in cancer: different compartment, different functionality? Front Immunol. 2020;11:531491.
  • Zhai L, Spranger S, Binder DC, et al. Molecular pathways: targeting IDO1 and other tryptophan dioxygenases for cancer Immunotherapy. Clin Cancer Res. 2015;21(24):5427–5433.
  • Feng X, Liao D, Liu D, et al. Development of indoleamine 2,3-Dioxygenase 1 inhibitors for cancer therapy and beyond: a recent perspective. J Med Chem. 2020;63(24):15115–15139.
  • Mangaonkar A, et al. A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on idoleamine 2,3 dioxygenase expression. Nature. 2017;7:12892.
  • Mabuchi R, Hara T, Matsumoto T, et al. High serum concentration of L-kynurenine predicts unfavorable outcomes in patients with acute myeloid leukemia. Leuk Lymphoma. 2016;57(1):92–98.
  • Joisten N, Kummerhoff F, Koliamitra C, et al. Exercise and the kynurenine pathway: current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training. Exerc Immunol Rev. 2020;26:24–42.
  • Peterlin P, Gaschet J, Guillaume T, et al. A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Med. 2021;10(2):642–648.
  • Sanchez-Correa B, Bergua JM, Campos C, et al. Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine. 2013;61(3):885–891.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.