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Commentary

Is ibrutinib the gold standard for therapy – naive elderly patients with CLL?

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Pages 1265-1266 | Received 08 Mar 2022, Accepted 09 Mar 2022, Published online: 25 Mar 2022

References

  • Burger JA, Robak T, Demirkan F, et al. Up to 6.5 years (median 4 years) of follow-up of first-line ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and high-risk genomic features: integrated analysis of two phase 3 studies. Leuk Lymphoma. 2022;1–12.
  • Burger JA, Barr PM, Robak T, et al. Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study. Leukemia. 2020;34(3):787–798.
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  • Mauro FR, Paoloni F, Molica S, et al. Efficacy of front-line ibrutinib and rituximab combination and the impact of treatment discontinuation in unfit patients with chronic lymphocytic leukemia: results of the GIMEMA LLC1114 study. Cancers. 2021;14(1):207.
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  • Munir T, Brown JR, O'Brien S, et al. Final analysis from RESONATE: up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma. Am J Hematol. 2019;94(12):1353–1363.

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