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Leukemia & Lymphoma Volume 63, 2022 - Issue 13
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Articles

Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients

Taylor Zaka Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Juehua Gaoa Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Amir Behdada Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;b Department of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Jayesh Mehtab Department of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Jessica K. Altmanb Department of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Peng Jia Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
,
Xinyan Lua Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAView further author information
&
Madina Sukhanovaa Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1843-7038View further author information
ORCID Icon show all
Pages 3200-3207 | Received 29 Mar 2022, Accepted 03 Aug 2022, Published online: 22 Aug 2022

References

  • Swerdlow SH, Campo E, Harris NL. World health organization classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2017.
  • Xie W, Xu J, Hu S, et al. iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation and dismal outcome. Mod Pathol. 2020;33(7):1389–1397.
  • Johnson RC, Weinberg OK, Cascio MJ, et al. Cytogenetic variation of B-Lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21): a Multi-Institutional series review. Am J Clin Pathol. 2015;144(1):103–112.
  • Harrison CJ, Moorman AV, Schwab C, Ponte di Legno International Workshop in Childhood Acute Lymphoblastic Leukemia, et al. An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome. Leukemia. 2014;28(5):1015–1021.
  • Li Y, Schwab C, Ryan S, et al. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature. 2014;508(7494):98–102.
  • Tsuchiya KD, Davis B, Gardner RA. Is intrachromosomal amplification of chromosome 21 (iAMP21) always intrachromosomal? Cancer Genet. 2017;218-219:10–14.
  • Heerema NA, Carroll AJ, Devidas M, et al. Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group. J Clin Oncol. 2013;31(27):3397–3402.
  • Shaffer LG, Schmid M, McGowan-Jordan J, International Standing Committee on Human Cytogenomic N. ISCN: an international system for human cytogenomic nomenclature. Basel: Karger; 2016.
  • He J, Abdel-Wahab O, Nahas MK, et al. Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. Blood. 2016;127(24):3004–3014.
  • Korbel JO, Campbell PJ. Criteria for inference of chromothripsis in cancer genomes. Cell. 2013;152(6):1226–1236.
  • Stock W, Luger SM, Advani AS, et al. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood. 2019;133(14):1548–1559. Blood. 2019;134(13):1111.
  • Badar T, Szabo A, Advani A, et al. Real-world outcomes of adult B-cell acute lymphocytic leukemia patients treated with blinatumomab. Blood Adv. 2020;4(10):2308–2316.
  • Goodman AM, Kato S, Bazhenova L, et al. Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Mol Cancer Ther. 2017;16(11):2598–2608.
  • Toft N, Birgens H, Abrahamsson J, et al. Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia. Leukemia. 2018;32(3):606–615.
  • Rand V, Parker H, Russell LJ, et al. Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia. Blood. 2011;117(25):6848–6855.
  • Schwab CJ, Chilton L, Morrison H, et al. Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features. Haematologica. 2013;98(7):1081–1088.
  • Rausch T, Jones DT, Zapatka M, et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell. 2012;148(1-2):59–71.
  • Bochtler T, Granzow M, Stölzel F, et al. Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia. Blood. 2017;129(10):1333–1342.
  • Kuchinskaya E, Nordgren A, Heyman M, et al. Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles? Leukemia. 2007;21(6):1327–1330.
  • Strefford JC, van Delft FW, Robinson HM, et al. Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci U S A. 2006;103(21):8167–8172.
  • Sinclair PB, Parker H, An Q, et al. Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy. Hum Mol Genet. 2011;20(13):2591–2602.

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