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Leukemia & Lymphoma Volume 64, 2023 - Issue 1
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Letters to the Editor

ETV6::ACSL6 fusion gene in myeloid malignancies with eosinophilia: a report of two cases with t(5;12) or normal karyotype

Tingting Zhanga Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
,
Qian Wanga Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
,
Yi Xua Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
,
Man Wanga Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
,
Zhenni Maa Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
,
Jinlan Pana Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8042-537XView further author information
ORCID Icon &
Suning Chena Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;b Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaCorrespondence[email protected]
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Pages 225-229 | Received 19 Jun 2022, Accepted 13 Oct 2022, Published online: 31 Oct 2022

References

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  • Yagasaki F, Jinnai I, Yoshida S, et al. Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5; 12)(q31; p13). Genes Chromosom Cancer. 1999;26(3):192–202.
  • Cools J, Mentens N, Odero MD, et al. Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4; 12)(q11-q12; p13) or t(5;12)(q31; p13). Blood. 2002;99(5):1776–1784.
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  • Luca-Johnson D, Ninfea JIR, Pearson L, et al. Myeloid neoplasms with t(5; 12) and ETV6-ACSL6 gene fusion, potential mimickers of myeloid neoplasm with PDGFRB rearrangement: case report with imatinib therapy and review of the literature. Case Rep Med. 2016;2016:8324791.
  • Su RJ, Jonas BA, Welborn J, et al. Chronic eosinophilic leukemia, NOS with t(5; 12)(q31; p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia. Hum Pathol. 2016;5:6–9.
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  • Baldazzi C, Luatti S, Marzocchi G, et al. t(5;12)(q31;p13)/ETV6::ACSL6 and t(6;9)(p23;q34)/DEK::NUP214 concurrence in acute myeloid leukemia: an unusual association of two rare abnormalities. Cancer Genet. 2022;262–263:35–39.
  • Wu X, Cai H, Qiu Y, et al. ETV6-ACSL6 fusion gene in myeloid neoplasms: clinical spectrum, current practice, and outcomes. Orphanet J Rare Dis. 2020;15(1):192.
  • Tang Z, Toruner GA, Tang G, et al. Chronic myeloid leukemia with insertion-derived BCR–ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis. Mod Pathol. 2020;33(10):2035–2045.
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