Advanced search
Publication Cover
Leukemia & Lymphoma Volume 64, 2023 - Issue 2
Submit an article Journal homepage
258
Views
2
CrossRef citations to date
0
Altmetric
Letters to the Editor

Frequent detection of CBFA2T3::GLIS2 fusion and RAM-phenotype in pediatric non-Down syndrome acute megakaryoblastic leukemia: a possible novel relationship with aberrant cytoplasmic CD3 expression

Yan Chen Wongworawata Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0003-0430-0265
ORCID Icon,
Ghazaleh Eskandaria Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-7535-6285
ORCID Icon,
Amos Gaikwadc Texas Children’s Cancer Center Laboratories, Texas Children’s Hospital, Houston, TX, USA
,
Andrea N. Marcogliesea Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-1458-9675
ORCID Icon,
Lizmery S. Fergusonb Department of Pathology, Texas Children’s Hospital, Houston, TX, USA
,
Julienne Brackettd Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-6782-1044
ORCID Icon,
Jyotinder N. Puniaa Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USA
,
M. Tarek Elghetanya Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USA
,
Reshma Kulkarnic Texas Children’s Cancer Center Laboratories, Texas Children’s Hospital, Houston, TX, USA
,
Pulivarthi H. Raoc Texas Children’s Cancer Center Laboratories, Texas Children’s Hospital, Houston, TX, USA
,
Jo Ringrosec Texas Children’s Cancer Center Laboratories, Texas Children’s Hospital, Houston, TX, USA
,
Dolores H. Lopez-Terradaa Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USA;c Texas Children’s Cancer Center Laboratories, Texas Children’s Hospital, Houston, TX, USA;d Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-6584-420X
ORCID Icon,
Angshumoy Roya Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USA;d Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0001-7248-8576
ORCID Icon,
Choladda V. Currya Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0003-4783-6991
ORCID Icon &
Kevin E. Fishera Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;b Department of Pathology, Texas Children’s Hospital, Houston, TX, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6179-0937
ORCID Icon show all
Pages 462-467 | Received 13 Jul 2022, Accepted 03 Oct 2022, Published online: 08 Nov 2022

References

  • Eidenschink Brodersen L, Alonzo TA, Menssen AJ, et al. A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children’s Oncology Group. Leukemia. 2016;30(10):2077–2080.
  • Panda D, Chatterjee G, Sardana R, et al. Utility of CD36 as a novel addition to the immunophenotypic signature of RAM-phenotype acute myeloid leukemia and study of its clinicopathological characteristics. Cytometry B Clin Cytom. 2021;100(2):206–217.
  • Barnard DR, Alonzo TA, Gerbing RB, et al. Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: report from the Children’s Oncology Group. Pediatr Blood Cancer. 2007;49(1):17–22.
  • de Rooij JD, Branstetter C, Ma J, et al. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017;49(3):451–456.
  • Masetti R, Bertuccio SN, Pession A, et al. CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity. Br J Haematol. 2019;184(3):337–347.
  • Masetti R, Pigazzi M, Togni M, et al. CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype. Blood. 2013;121(17):3469–3472.
  • Gruber TA, Larson Gedman A, Zhang J, et al. An inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell. 2012;22(5):683–697.
  • Thiollier C, Lopez CK, Gerby B, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med. 2012;209(11):2017–2031.
  • Thirant C, Ignacimouttou C, Lopez CK, et al. ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and Self-Renewal in pediatric acute megakaryoblastic leukemia. Cancer Cell. 2017;31(3):452–465.
  • Rossi JG, Rubio P, Alonso CN, et al. Cytoplasmic CD3 expression in infant acute megakaryoblastic leukemia: a new ambiguous lineage subtype? Leuk Res. 2018;71:6–12.
  • Alexander TB, Orgel E. Mixed phenotype acute leukemia: current approaches to diagnosis and treatment. Curr Oncol Rep. 2021;23(2):22.
  • Giri S, Pathak R, Prouet P, et al. Acute megakaryocytic leukemia is associated with worse outcomes than other types of acute myeloid leukemia. Blood. 2014;124(25):3833–3834.
  • Swerdlow SC, Campo E, Harris NL, et al. WHO Classification of tumours of haematopoietic and lymphoid tissues (Revised 4th edition). Lyon: International Agency for Research on Cancer (IARC); 2017.
  • Gaikwad AS, Donohue RE, Elghetany MT, et al. Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B-acute lymphoblastic leukemia. Int J Clin Exp Pathol. 2014;7(9):6225–6230.
  • Lamble AJ, Eidenschink Brodersen L, Alonzo TA, et al. CD123 expression is associated with high-risk disease characteristics in childhood acute myeloid leukemia: a report from the Children’s Oncology Group. J Clin Oncol. 2022;40(3):252–261.
  • Foster JH, Williams CL, Elghetany MT, et al. Monozygotic twins with non-Down syndrome associated MLL-rearranged hematologic malignancy and megakaryoblastic differentiation. Leuk Lymphoma. 2019;60(4):1083–1086.
  • Smith JL, Ries RE, Hylkema T, et al. Comprehensive transcriptome profiling of cryptic CBFA2T3-GLIS2 fusion-positive AML defines novel therapeutic options: a COG and TARGET pediatric AML study. Clin Cancer Res. 2020;26(3):726–737.
  • Woolthuis CM, Park CY. Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage. Blood. 2016;127(10):1242–1248.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.