Advanced search
Publication Cover
Leukemia & Lymphoma Volume 64, 2023 - Issue 1
Submit an article Journal homepage
198
Views
0
CrossRef citations to date
0
Altmetric
Letters to the Editor

Richter transformation to aggressive plasmablastic neoplasm related to selection of a BTK-mutated clone in a patient with CLL/SLL treated by ibrutinib

Barina Aqila Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;Correspondence[email protected]
,
Amandeep Kaura Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
,
Josean Ramosa Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
,
Madina Sukhanovaa Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
,
Shuo Mab Robert H. Lurie Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Chicago, IL, USA
,
Juehua Gaoa Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
,
Xinyan Lua Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
,
Yi-Hua Chena Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
&
Qing Chena Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA;
 show all
Pages 242-245 | Received 26 Aug 2022, Accepted 17 Oct 2022, Published online: 06 Nov 2022

References

  • Campo E, Ghia P, Montserrat E, et al. Chronic lymphocytic leukemia/small lymphocytic lymphoma. editors: Campo E, Ghia P, Montserrat E, et al. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed., Rev. ed. Lyon (France): IARC; 2017:216–221.
  • Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter’s syndrome reveals disease heterogeneity and predicts survival after transformation. Blood. 2011;117(12):3391–3401.
  • Wang Y, Ding W. Richter transformation of chronic lymphocytic leukemia in the era of novel agents. Clin Adv Hematol Oncol. 2020;18(6):348–357.
  • Martinez D, Valera A, Perez NS, et al. Plasmablastic transformation of low-grade B-cell lymphomas. Report on 6 cases. Am J Surg Pathol. 2013;37(2):272–281.  
  • Pan Z, Xie Q, Repertinger S, et al. Plasmablastic transformation of low grade CD5+ B-cell lymphoproliferative disorder with MYC gene rearrangements. Hum Pathol. 2013;44(10):2139–2148.
  • Hayes C, Ma Y, Delioukina M, et al. Bone marrow manifestation of plasmablastic transformation of chronic lymphocytic leukemia: a case report. J Hematopathol. 2014;7(4):189–193.
  • Vega F, Chang CC, Medeiros L, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18(6):806–815.
  • Frontzek F, Staiger AM, Zapukhlyak M, et al. Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma. Nat Commun. 2021;12(1):5183.
  • Castillo JJ, Bibas M, Miranda RN. The biology and treatment of plasmablastic lymphoma. Blood. 2015;125(15):2323–2330.
  • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32–42.
  • Kadri S, Lee J, Fitzpatrick C, et al. Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL. Blood Adv. 2017;1(12):715–727.
  • Lampson LB, Brown JR. Are BTK and PLCG2 mutations necessary and sufficient for ibrutinib resistance in chronic lymphocytic leukemia? Expert Rev Hematol. 2018;11(3):185–194.
  • Rossi D, Spina V, Cerri M, et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res. 2009;15(13):4415–4422.
  • Stamatopoulos B, Smith T, Crompot E, et al. The light chain IgLV3-21 defines a new poor prognostic subgroup in chronic lymphocytic leukemia: results of a multicenter study. Clin Cancer Res. 2018;24(20):5048–5057.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.