References
- Munoz-Garcia N, Jara-Acevedo M, Caldas C, et al. STAT3 and STAT5B mutations in T/NK-Cell chronic lymphoproliferative disorders of large granular lymphocytes (LGL): association with disease features. Cancers. 2020;12(12):3508. doi: 10.3390/cancers12123508
- Cheon H, Xing JC, Moosic KB, et al. Genomic landscape of TCRalphabeta and TCRgammadelta T-large granular lymphocyte leukemia. Blood. 2022;139(20):3058–3072. doi: 10.1182/blood.2021013164
- Chen YH, Chadburn A, Evens AM, et al. Clinical, morphologic, immunophenotypic, and molecular cytogenetic assessment of CD4-/CD8-gammadelta T-cell large granular lymphocytic leukemia. Am J Clin Pathol. 2011;136(2):289–299. doi: 10.1309/AJCPTFFQ18JMYKDF
- Sandberg Y, Almeida J, Gonzalez M, et al. TCRgammadelta + large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCRgammadelta + T-cells. Leukemia. 2006;20(3):505–513. doi: 10.1038/sj.leu.2404112
- Lamy T, Moignet A, Loughran TP.Jr. LGL leukemia: from pathogenesis to treatment. Blood. 2017;129(9):1082–1094. doi: 10.1182/blood-2016-08-692590
- Lamy T, Loughran TP.Jr. How I treat LGL leukemia. Blood. 2011;117(10):2764–2774. doi: 10.1182/blood-2010-07-296962
- Koskela HL, Eldfors S, Ellonen P, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med. 2012;366(20):1905–1913. doi: 10.1056/NEJMoa1114885
- Jerez A, Clemente MJ, Makishima H, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. 2012;120(15):3048–3057. doi: 10.1182/blood-2012-06-435297
- Andersson EI, Tanahashi T, Sekiguchi N, et al. High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. Blood. 2016;128(20):2465–2468. doi: 10.1182/blood-2016-06-724856
- Teramo A, Barila G, Calabretto G, et al. Insights into genetic landscape of large granular lymphocyte leukemia. Front Oncol. 2020;10:152. doi: 10.3389/fonc.2020.00152
- Barila G, Teramo A, Calabretto G, et al. Stat3 mutations impact on overall survival in large granular lymphocyte leukemia: a single-center experience of 205 patients. Leukemia. 2020;34(4):1116–1124. doi: 10.1038/s41375-019-0644-0
- Rajala HL, Olson T, Clemente MJ, et al. The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. Haematologica. 2015;100(1):91–99. doi: 10.3324/haematol.2014.113142
- Barila G, Grassi A, Cheon H, et al. Tgammadelta LGLL identifies a subset with more symptomatic disease: analysis of an international cohort of 137 patients. Blood. 2023;141(9):1036–1046. doi: 10.1182/blood.2021013489
- Rivero A, Mozas P, Jimenez L, et al. Clinicobiological characteristics and outcomes of patients with T-Cell large granular lymphocytic leukemia and chronic lymphoproliferative disorder of natural killer cells from a single institution. Cancers (Basel). 2021;13(15):3900. doi: 10.3390/cancers13153900
- Swerdlow SC, Harris NL, Jaffe ES, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press. 2017
- Fei F, Natkunam Y, Zehnder JL, et al. Diagnostic impact of Next-Generation sequencing panels for lymphoproliferative neoplasms on Small-Volume biopsies. Am J Clin Pathol. 2022;158(3):345–361. doi: 10.1093/ajcp/aqac045
- Rajala HL, Eldfors S, Kuusanmaki H, et al. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood. 2013;121(22):4541–4550. doi: 10.1182/blood-2012-12-474577
- Olson TL, Cheon H, Xing JC, et al. Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias. Blood. 2021;138(8):662–673. doi: 10.1182/blood.2020005831
- Kerr CM, Clemente MJ, Chomczynski PW, et al. Subclonal STAT3 mutations solidify clonal dominance. Blood Adv. 2019;3(6):917–921. doi: 10.1182/bloodadvances.2018027862
- Qu S, Jia Y, Wang H, et al. STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms. Leuk Lymphoma. 2021;62(6):1506–1509. doi: 10.1080/10428194.2020.1869964
- Komrokji RS, Ali NA, Sallman D, et al. Characterization of myelodysplastic syndromes (MDS) with T-cell large granular lymphocyte proliferations (LGL). Leukemia. 2020;34(11):3097–3099. doi: 10.1038/s41375-020-0928-4
- Kavesh M, Mohebnasab M, Angel MR, et al. Distinguishing STAT3/STAT5B-mutated large granular lymphocyte leukemia from myeloid neoplasms by genetic profiling. Blood Adv. 2023;7(1):40–45. doi: 10.1182/bloodadvances.2022008192
- Teramo A, Barila G, Calabretto G, et al. STAT3 mutation impacts biological and clinical features of T-LGL leukemia. Oncotarget. 2017;8(37):61876–61889. doi: 10.18632/oncotarget.18711
- Pastoret C, Desmots F, Drillet G, et al. Linking the KIR phenotype with STAT3 and TET2 mutations to identify chronic lymphoproliferative disorders of NK cells. Blood. 2021;137(23):3237–3250. doi: 10.1182/blood.2020006721
- Ai K, Li M, Wu P, et al. Concurrence of myelodysplastic syndromes and large granular lymphocyte leukemia: clinicopathological features, mutational profile and gene ontology analysis in a single center. Am J Cancer Res. 2021;11(4):1616–1631
- Huh YO, Medeiros LJ, Ravandi F, et al. T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. Am J Clin Pathol. 2009;131(3):347–356. doi: 10.1309/AJCP6YHI1JEXAWAP
- Saunthararajah Y, Molldrem JL, Rivera M, et al. Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features. Br J Haematol. 2001;112(1):195–200. doi: 10.1046/j.1365-2141.2001.02561.x
- Steensma DP, Bejar R, Jaiswal S, et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood. 2015;126(1):9–16. doi: 10.1182/blood-2015-03-631747
- Raess PW, Cascio MJ, Fan G, et al. Concurrent STAT3, DNMT3A, and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential. Am J Hematol. 2017;92(1):E6–E8. doi: 10.1002/ajh.24586